scholarly journals Chronic prostatitis/chronic pelvic pain syndrome impairs erectile function through increased endothelial dysfunction, oxidative stress, apoptosis, and corporal fibrosis in a rat model

Andrology ◽  
2016 ◽  
Vol 4 (6) ◽  
pp. 1209-1216 ◽  
Author(s):  
Y. Hu ◽  
X. Niu ◽  
G. Wang ◽  
J. Huang ◽  
M. Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Pelvic Pain ◽  
Rat Model ◽  
Erectile Function ◽  
Chronic Prostatitis ◽  
Chronic Pelvic Pain ◽  
Chronic Pelvic Pain Syndrome ◽  
Pain Syndrome ◽  
Pelvic Pain Syndrome

Changes in erectile organ structure and function in a rat model of chronic prostatitis/chronic pelvic pain syndrome

Andrologia ◽  
2015 ◽  
Vol 48 (3) ◽  
pp. 243-251 ◽  
Author(s):  
X.-J. Wang ◽  
L.-L. Xia ◽  
T.-Y. Xu ◽  
X.-H. Zhang ◽  
Z.-W. Zhu ◽  
...  
Keyword(s):  
Pelvic Pain ◽  
Rat Model ◽  
Chronic Prostatitis ◽  
Chronic Pelvic Pain ◽  
Chronic Pelvic Pain Syndrome ◽  
Pain Syndrome ◽  
Structure And Function ◽  
Pelvic Pain Syndrome ◽  
And Function

scholarly journals Experimental Chronic Prostatitis/Chronic Pelvic Pain Syndrome Increases Anxiety-Like Behavior: The Role of Brain Oxidative Stress, Serum Corticosterone, and Hippocampal Parvalbumin-Positive Interneurons

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Nikola Šutulović ◽  
Željko Grubač ◽  
Sonja Šuvakov ◽  
Djurdja Jerotić ◽  
Nela Puškaš ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pelvic Pain ◽  
Chronic Prostatitis ◽  
Chronic Pelvic Pain ◽  
Chronic Pelvic Pain Syndrome ◽  
Pain Syndrome ◽  
Pelvic Pain Syndrome ◽  
Serum Corticosterone ◽  
Brain Oxidative Stress ◽  
The Brain

Mechanisms of the brain-related comorbidities in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are still largely unknown, although CP/CPPS is one of the major urological problems in middle-aged men, while these neuropsychological incapacities considerably diminish life quality. The objectives of this study were to assess behavioral patterns in rats with CP/CPPS and to determine whether these patterns depend on alterations in the brain oxidative stress, corticosterone, and hippocampal parvalbumin-positive (PV+) interneurons. Adult male Wistar albino rats from CP/CPPS (intraprostatic injection of 3% λ-carrageenan, day 0) and sham (0.9% NaCl) groups were subjected to pain and anxiety-like behavior tests (days 2, 3, and 7). Afterwards, rats were sacrificed and biochemical and immunohistochemical analyses were performed. Scrotal allodynia and prostatitis were proven in CP/CPPS, but not in sham rats. Ethological tests (open field, elevated plus maze, and light/dark tests) revealed significantly increased anxiety-like behavior in rats with CP/CPPS comparing to their sham-operated mates starting from day 3, and there were significant intercorrelations among parameters of these tests. Increased oxidative stress in the hippocampus, thalamus, and cerebral cortex, as well as increased serum corticosterone levels and decreased number of hippocampal PV+ neurons, was shown in CP/CPPS rats, compared to sham rats. Increased anxiety-like behavior in CP/CPPS rats was significantly correlated with these brain biochemical and hippocampal immunohistochemical alterations. Therefore, the potential mechanisms of observed behavioral alterations in CP/CPPS rats could be the result of an interplay between increased brain oxidative stress, elevated serum corticosterone level, and loss of hippocampal PV+ interneurons.

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