Effects of short‐term administration of melatonin before gonadectomy on oxidative stress, cortisol and sex hormones in male dogs

Andrologia ◽  
2021 ◽  
Author(s):  
Asghar Mogheiseh ◽  
Saeed Nazifi ◽  
Mohsen Gharibnavaz ◽  
Reza Zamani ◽  
Behrooz Nikahval ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sex Hormones ◽  
Short Term ◽  
Term Administration

Does short-term administration of glucagon-like peptide type 2 affect bone mass and markers of bone remodeling in short bowel patients?

2001 ◽  
Vol 120 (5) ◽  
pp. A314-A314
Author(s):  
K HADERSLEV ◽  
P JEPPESEN ◽  
B HARTMANN ◽  
J THULESEN ◽  
J GRAFF ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Remodeling ◽  
Short Term ◽  
Short Bowel ◽  
Term Administration ◽  
Glucagon Like Peptide

scholarly journals Oxidative Stress, Glutathione Metabolism, and Liver Regeneration Pathways Are Activated in Hereditary Tyrosinemia Type 1 Mice upon Short-Term Nitisinone Discontinuation

Genes ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 3
Author(s):  
Haaike Colemonts-Vroninks ◽  
Jessie Neuckermans ◽  
Lionel Marcelis ◽  
Paul Claes ◽  
Steven Branson ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Liver Regeneration ◽  
The Body ◽  
Glutathione Metabolism ◽  
Short Term ◽  
Therapeutic Regime ◽  
Tyrosinemia Type 1 ◽  
Hereditary Tyrosinemia

Hereditary tyrosinemia type 1 (HT1) is an inherited condition in which the body is unable to break down the amino acid tyrosine due to mutations in the fumarylacetoacetate hydrolase (FAH) gene, coding for the final enzyme of the tyrosine degradation pathway. As a consequence, HT1 patients accumulate toxic tyrosine derivatives causing severe liver damage. Since its introduction, the drug nitisinone (NTBC) has offered a life-saving treatment that inhibits the upstream enzyme 4-hydroxyphenylpyruvate dioxygenase (HPD), thereby preventing production of downstream toxic metabolites. However, HT1 patients under NTBC therapy remain unable to degrade tyrosine. To control the disease and side-effects of the drug, HT1 patients need to take NTBC as an adjunct to a lifelong tyrosine and phenylalanine restricted diet. As a consequence of this strict therapeutic regime, drug compliance issues can arise with significant influence on patient health. In this study, we investigated the molecular impact of short-term NTBC therapy discontinuation on liver tissue of Fah-deficient mice. We found that after seven days of NTBC withdrawal, molecular pathways related to oxidative stress, glutathione metabolism, and liver regeneration were mostly affected. More specifically, NRF2-mediated oxidative stress response and several toxicological gene classes related to reactive oxygen species metabolism were significantly modulated. We observed that the expression of several key glutathione metabolism related genes including Slc7a11 and Ggt1 was highly increased after short-term NTBC therapy deprivation. This stress response was associated with the transcriptional activation of several markers of liver progenitor cells including Atf3, Cyr61, Ddr1, Epcam, Elovl7, and Glis3, indicating a concreted activation of liver regeneration early after NTBC withdrawal.

Nephrotoxicity of borocaptate after short-term administration in rabbits

Toxicology ◽  
1993 ◽  
Vol 79 (2) ◽  
pp. 99-108 ◽  
Author(s):  
I JANKU ◽  
E BUCHAR ◽  
Z JIRICKA
Keyword(s):  
Short Term ◽  
Term Administration

scholarly journals Effects of short-term administration of estradiol on reperfusion arrhythmias in rats of different ages

2012 ◽  
Vol 45 (12) ◽  
pp. 1248-1254 ◽  
Author(s):  
S.Q. Savergnini ◽  
A.M. Reis ◽  
R.A.S. Santos ◽  
P.E.B. Santos ◽  
A.J. Ferreira ◽  
...  
Keyword(s):  
Short Term ◽  
Reperfusion Arrhythmias ◽  
Different Ages ◽  
Term Administration
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