Protective effect of liraglutide on experimental testicular ischaemia reperfusion in rats

Andrologia ◽  
2021 ◽  
Vol 53 (4) ◽  
Author(s):  
Recep B. Degirmentepe ◽  
Fatih Altunrende ◽  
Muammer Bozkurt ◽  
Erkan Merder ◽  
Alper Otunctemur ◽  
...  
Keyword(s):  
Protective Effect ◽  
Ischaemia Reperfusion

Protective effect of dl-3n-butylphthalide preconditioning on focal cerebral ischaemia-reperfusion injury in rats

2013 ◽  
Vol 25 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Pei-Lei Zhang ◽  
Hai-Tao Lu ◽  
Jun-Gong Zhao ◽  
Ming-Hua Li
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Neurological Deficit ◽  
Cerebral Ischaemia ◽  
Sham Operation ◽  
Focal Cerebral Ischaemia ◽  
Vegf Expression ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Infarction Volume

ObjectiveTo investigate the effect of dl-3n-butylphthalide (NBP) on the protection of cerebral tissue and possible mechanism on ischaemia-reperfusion injury, and to find out whether NBP therapy can extend the reperfusion window in an experimental stroke model in rats.MethodsSeventy-two Sprague-Dawley rats were randomly divided into sham operation, ischaemia-reperfusion and ischaemia-reperfusion with NBP groups. Focal cerebral ischaemia was induced using the modified intraluminal thread method and maintained for 2, 3 or 4 h. The ischaemia-reperfusion group received reperfusion immediately after ischaemia-reperfusion. The NBP group received intraperitoneal injection of NBP immediately after ischaemia, followed by reperfusion. The sham operation group received only injection of physiological saline. The cerebral infarction volume and neurological deficit were analysed, and vascular endothelial growth factor (VEGF) expression in brain tissues was visualised by immunohistochemistry.ResultsNBP treatment caused a significant decrease in both infarction volume and neurological deficit compared with the ischaemia-reperfusion group at corresponding time points in each (p < 0.05). In the NBP group, the infarction volume and neurological deficit did not change with different ischaemia times. The expression of VEGF was significantly decreased in the ischaemia-reperfusion group compared with the sham group (p < 0.01), while this change was partly prevented in the NBP group (p < 0.01). The expression of VEGF in brain tissue in both the NBP and ischaemia-reperfusion groups gradually decreased when the ischaemic period was prolonged.ConclusionNBP treatment has a protective effect against cerebral ischaemia; this possible mechanism maybe related to the VEGF expression and may extend the reperfusion window for subsequent salvage of cerebral ischaemia by reperfusion.

Protective effect of pheniramines against mesenteric ischaemia/reperfusion-induced injury

2009 ◽  
Vol 58 (S1) ◽  
pp. 68-69 ◽  
Author(s):  
V. Nosáľová ◽  
K. Drábiková ◽  
V. Jančinová ◽  
R. Nosáľ ◽  
T. Mačičková ◽  
...  
Keyword(s):  
Protective Effect ◽  
Mesenteric Ischaemia ◽  
Ischaemia Reperfusion

scholarly journals The protective effect of resveratrols on ischaemia-reperfusion injuries of rat hearts is correlated with antioxidant efficacy

2002 ◽  
Vol 135 (7) ◽  
pp. 1627-1633 ◽  
Author(s):  
Li-Man Hung ◽  
Ming-Jai Su ◽  
Wing-Keung Chu ◽  
Chin-Wei Chiao ◽  
Wan-Fen Chan ◽  
...  
Keyword(s):  
Protective Effect ◽  
Ischaemia Reperfusion ◽  
Rat Hearts

The protective effect of α-lipoic acid in experimental ovarian ischaemia-reperfusion injury

2007 ◽  
Vol 47 (6) ◽  
pp. 499-503 ◽  
Author(s):  
Emine COSAR ◽  
Figen Kır SAHIN ◽  
Gülengül KÖKEN ◽  
Hatice TOY ◽  
Kemal BASARALI ◽  
...  
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Lipoic Acid ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

Protective effect ofL-carnitine on testicular ischaemia–reperfusion injury in rats

2007 ◽  
Vol 25 (6) ◽  
pp. 611-618 ◽  
Author(s):  
Dikmen Dokmeci ◽  
Mustafa Inan ◽  
Umit Nusret Basaran ◽  
Omer Yalcin ◽  
Nurettin Aydogdu ◽  
...  
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion
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