Oxidative stress markers in seminal plasma of idiopathic infertile men may be associated with glutathione S‐transferase M1 and T1 null genotypes

Andrologia ◽  
2020 ◽  
Vol 52 (9) ◽  
Author(s):  
Erfaneh Barati ◽  
Mohammad Karimian ◽  
Hossein Nikzad
2010 ◽  
Vol 43 (13-14) ◽  
pp. 1124-1128 ◽  
Author(s):  
M.D. Mustafa ◽  
Rahul Pathak ◽  
Tanzeel Ahmed ◽  
Rafat S. Ahmed ◽  
A.K. Tripathi ◽  
...  

BMC Genomics ◽  
2014 ◽  
Vol 15 (Suppl 2) ◽  
pp. P42 ◽  
Author(s):  
Saad Alshahrani ◽  
Ashok Agarwal ◽  
Mourad Assidi ◽  
Adel M Abuzenadah ◽  
Damayanthi Durairajanayagam ◽  
...  

BMC Genomics ◽  
2014 ◽  
Vol 15 (Suppl 2) ◽  
pp. P56
Author(s):  
Saad Alshahrani ◽  
Ashok Agarwal ◽  
Mourad Assidi ◽  
Adel M Abuzenadah ◽  
Ahmet Ayaz ◽  
...  

2012 ◽  
Vol 31 (3) ◽  
pp. 184-192 ◽  
Author(s):  
Dijana Mirić ◽  
Bojana Kisić ◽  
Lepša Žorić ◽  
Zana Dolićanin ◽  
Radoslav Mitić ◽  
...  

The Impact of Senile Cataract Maturity on Blood Oxidative Stress Markers and Glutathione-Dependent Antioxidants: Relations with Lens VariablesOxidative stress is implicated in senile cataract (SC) genesis, although the impact of SC maturity on blood oxidative stress markers is unclear. Total hydroperoxides, malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione S-transferase (GST) were measured in the blood and lens samples of patients having either immature (n=31) or mature SC (n=50), and in 22 blood samples from noncataract controls. Compared to controls, SC patients had higher plasma MDA and serum GST, and decreased plasma GR and GSH levels. Plasma GPx as well as hydroperoxides differed from control values only in patients with mature SC. The multivariate logistic regression analysis showed that the fall of plasma GR activity (OR 5.14; CI 1.82-14.51;p=0.0020), as well as serum GST activity (OR 3.84; CI 1.36-10.83;p=0.0108) were independently associated with the maturity of SC. Lens hydroperoxides, MDA and GST, showed no correlation with correspondent blood values, in contrast to GPx (r=0.715; p<0.001) and GR (r=0.703; p<0.001). This study showed that the severity of SC is associated with increased systemic oxidative stress, which could be due to the fall of GSH-dependent antioxidant enzymes activities.


2021 ◽  
Vol 68 (3) ◽  
pp. 521-531
Author(s):  
Miraç Uçkun ◽  
Ertan Yoloğlu ◽  
Aysel Alkan Uçkun ◽  
Özden Barım Öz

Thiamethoxam (Thmx) is a globally used neonicotinoid pesticide contaminated in freshwater ecosystems with residues detected in fishery products. Astacus leptodactylus is a popular freshwater crustacean that is cultivated and exported in many countries. In this study, we investigated the acute toxic effects of Thmx on A. leptodactylus using various biomarkers (acetylcholinesterase, carboxylesterase, glutathione S-transferase, glutathione, superoxide dismutase, glutathione peroxidase, glutathione reductase, and adenosinetriphosphatases). The 96-h LC50 value of Thmx was calculated as 8.95 mg active ingredient L–1. As the dose of Thmx increased, oxidative stress was induced by the inhibition/activation of antioxidant enzymes, while the activities of acetylcholinesterase, carboxylesterase and adenosinetriphosphatases were inhibited. As a result, it can be said that Thmx has highly toxic effects on crayfish, therefore they are under threat in the areas where this pesticide is used.


2013 ◽  
Vol 100 (3) ◽  
pp. S440-S441 ◽  
Author(s):  
S. Alshahrani ◽  
R. Sharma ◽  
S. Gupta ◽  
D. Durairajanayagam ◽  
E. Sabanegh ◽  
...  

Author(s):  
Reveka Gyftaki ◽  
Sofia Gougoura ◽  
Nikolaos Kalogeris ◽  
Vasiliki Loi ◽  
George Koukoulis ◽  
...  

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