Low‐dose heavy metal mixture (lead, cadmium and mercury)‐induced testicular injury and protective effect of zinc and Costus afer in wistar albino rats

Andrologia ◽  
2020 ◽  
Vol 52 (9) ◽  
Author(s):  
Brilliance O. Anyanwu ◽  
Anthonet N. Ezejiofor ◽  
Ify L. Nwaogazie ◽  
Onyewuchi Akaranta ◽  
Orish E. Orisakwe
Keyword(s):  
Heavy Metal ◽  
Protective Effect ◽  
Low Dose ◽  
Albino Rats ◽  
Metal Mixture ◽  
Wistar Albino Rats ◽  
Testicular Injury ◽  
Costus Afer

scholarly journals Neuroprotective effect of Costus afer on low dose heavy metal mixture (lead, cadmium and mercury) induced neurotoxicity via antioxidant, anti-inflammatory activities

2020 ◽  
Vol 7 ◽  
pp. 1032-1038 ◽  
Author(s):  
Brilliance O. Anyanwu ◽  
Chinna N. Orish ◽  
Anthonet N. Ezejiofor ◽  
Ify L. Nwaogazie ◽  
Orish E. Orisakwe
Keyword(s):  
Heavy Metal ◽  
Low Dose ◽  
Neuroprotective Effect ◽  
Metal Mixture ◽  
Anti Inflammatory ◽  
Costus Afer

scholarly journals Protective Effect of Costus afer Aqueous Leaf Extract (CALE) on Low-Dose Heavy Metal Mixture-Induced Alterations in Serum Lipid Profile and Hematological Parameters of Male Wistar Albino Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Brilliance O. Anyanwu ◽  
Chinna N. Orish ◽  
Anthonet N. Ezejiofor ◽  
Ify L. Nwaogazie ◽  
Orish E. Orisakwe ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Leaf Extract ◽  
Low Dose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Treated Group ◽  
Albino Rats ◽  
Metal Mixture ◽  
Aqueous Leaf Extract ◽  
Costus Afer

The present work investigated the protective effects of Costus afer Ker Gawl. aqueous leaf extract (CALE) on lipid profile and hematological changes induced by exposure to low-dose heavy metal mixture in male albino rats. The experimental animals were divided into six weight matched groups. The normal (group 1) and toxic (group 2) controls received deionized water and metal mixture (20 mg/kg PbCl2, 1.61 mg/kg CdCl2, and 0.40 mg/kg HgCl2), respectively. Test rats in groups 3, 4, and 5 were treated with metal mixture and CALE (750, 1500, and 2250 mg/kg, respectively), and group 6 received metal mixture and ZnCl2. All treatments were administered through oral gavage for 12 weeks. LDHMM caused a marked increase ( p < 0.05 ) in cholesterol, triglyceride, low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) levels and a decrease in high-density lipoprotein (HDL), percentage body weight gain, and feed and fluid intake. Also, a significant decrease in RBC, Hb, and PCV, a significant increase in WBC, and no significant increase in platelet PLT were observed in the metal mixture-treated group. But in CALE treated groups, their levels were found to attain almost normal values as found in normal control which is also similar to the zinc-treated group. Costus afer may hold a promise in improving lipid profile and hemodynamic picture in cardiovascular diseases.

Investigation on protective effect of Terminalia bellirica (Roxb.) against drugs induced cardiotoxicity in wistar albino rats

2020 ◽  
Vol 261 ◽  
pp. 113080
Author(s):  
Rahul Chaudhary ◽  
Richa Singh ◽  
Rajeev Verma ◽  
Prashant Kumar ◽  
Nitin Kumar ◽  
...  
Keyword(s):  
Protective Effect ◽  
Albino Rats ◽  
Terminalia Bellirica ◽  
Wistar Albino Rats

Protective Effect of Acetyl-L-Carnitine Against Doxorubicin-induced Cardiotoxicity in Wistar Albino Rats

2016 ◽  
Vol 47 (7) ◽  
pp. 506-514 ◽  
Author(s):  
Hatice Adiguzel Dundar ◽  
Muge Kiray ◽  
Mustafa Kir ◽  
Efsun Kolatan ◽  
Alper Bagriyanik ◽  
...  
Keyword(s):  
Protective Effect ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Effects of Safranal on Tissue Oxidative Stress in Sub-Chronic Thinner-Addicted Rats

2020 ◽  
Vol 71 (1) ◽  
pp. 1997
Author(s):  
M. DÜZ ◽  
A. F. FIDAN
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Protective Effect ◽  
Total Antioxidant Capacity ◽  
Reduced Glutathione ◽  
Control Group ◽  
Albino Rats ◽  
Total Antioxidant ◽  
Wistar Albino Rats ◽  
And Oxidative Stress

The present study was carried out to determine the effects of sub-chronic thinner addiction on the oxidant-antioxidant balance and oxidative stress on certain tissues and the possible protective effect of safranal against thinner toxication in rats. Adult male Wistar albino rats were randomly divided into four groups of 10 animals each as follows: control (C), safranal (S), thinner (T) and thinner+safranal (T+S). The control group received 1cc saline by gastric gavage. Safranal was administered to S and T+S groups by using gastric gavage at a dose of 100 mg/kg/day and volume of 0.1 mL/kg/day. Thinner inhalation was applied to T and T+S groups in a container with NaOH tablets twice a day. Levels of malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NOx) metabolites, total antioxidant capacity (TAS) and total oxidant capacity (TOS) were determined in liver, lung, brain, kidney and testis tissues of the rats. In the T+S group, it was observed that the MDA levels significantly decreased in all tissues, except the kidney, in comparison to the thinner inhalation group (p = 0.000). When the NOx levels of the T+S group were compared with the levels of the T group, it was concluded that there existed a statistically significant decrease in the NOx levels in alltissues (p = 0.000). In T+S group, it was observed that safranal either eliminated or mitigated oxidative stress that developed in tissues through decreasing MDA and TOS levels and increasing GSH and TAS levels and caused significant decreases in NOX levels in all tissues. As a result, it was determined that safranal, although not uniform for all tissue types, had a protective potential against the damaging effects of oxidative stress caused by sub-chronic thinner inhalation.

scholarly journals Induction of Epoxide Hydrolase, Glucuronosyl Transferase, and Sulfotransferase by Phenethyl Isothiocyanate in Male Wistar Albino Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Ahmad Faizal Abdull Razis ◽  
Noramaliza Mohd Noor ◽  
Nattaya Konsue
Keyword(s):  
Dietary Intake ◽  
Epoxide Hydrolase ◽  
Low Dose ◽  
Albino Rats ◽  
High Dose ◽  
Phenethyl Isothiocyanate ◽  
Enzyme Systems ◽  
Wistar Albino Rats ◽  
Glucuronosyl Transferase ◽  
Medium Dose

Phenethyl isothiocyanate (PEITC) is an isothiocyanate found in watercress as the glucosinolate (gluconasturtiin). The isothiocyanate is converted from the glucosinolate by intestinal microflora or when contacted with myrosinase during the chopping and mastication of the vegetable. PEITC manifested protection against chemically-induced cancers in various tissues. A potential mechanism of chemoprevention is by modulating the metabolism of carcinogens so as to promote deactivation. The principal objective of this study was to investigate in rats the effect of PEITC on carcinogen-metabolising enzyme systems such as sulfotransferase (SULT), N-acetyltransferase (NAT), glucuronosyl transferase (UDP), and epoxide hydrolase (EH) following exposure to low doses that simulate human dietary intake. Rats were fed for 2 weeks diets supplemented with PEITC at 0.06 µmol/g (low dose, i.e., dietary intake), 0.6 µmol/g (medium dose), and 6.0 µmol/g (high dose), and the enzymes were monitored in rat liver. At the Low dose, no induction of the SULT, NAT, and EH was noted, whereas UDP level was elevated. At the Medium dose, only SULT level was increased, whereas at the High dose marked increase in EH level was observed. It is concluded that PEITC modulates carcinogen-metabolising enzyme systems at doses reflecting human intake thus elucidating the mechanism of its chemoprevention.

scholarly journals Chemical constituents and protective effect of Ficus ingens (Miq.) Miq. on carbon tetrachloride-induced acute liver damage in male Wistar albino rats

2013 ◽  
Vol 17 (1) ◽  
pp. 125-133 ◽  
Author(s):  
Abd El Raheim M. Donia ◽  
Gamal A. Soliman ◽  
Ahmed M. Zaghloul ◽  
Saleh I. Alqasoumi ◽  
Amani S. Awaad ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Liver Damage ◽  
Chemical Constituents ◽  
Albino Rats ◽  
Acute Liver Damage ◽  
Wistar Albino Rats
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