Effect of pharmacological doses of niacin on testicular structure and function in normal and diabetic rats

Andrologia ◽  
2018 ◽  
Vol 50 (10) ◽  
pp. e13142
Author(s):  
Tahoora Shomali ◽  
Mahnaz Taherianfard ◽  
Maryam Dalvand ◽  
Fatemeh Namazi
Keyword(s):  
Diabetic Rats ◽  
Structure And Function ◽  
And Function

Discordant effects of guanidines on renal structure and function and on regional vascular dysfunction and collagen changes in diabetic rats

Diabetes ◽  
1997 ◽  
Vol 46 (1) ◽  
pp. 94-106 ◽  
Author(s):  
J. R. Nyengaard ◽  
K. Chang ◽  
S. Berhorst ◽  
K. M. Reiser ◽  
J. R. Williamson ◽  
...  
Keyword(s):  
Vascular Dysfunction ◽  
Diabetic Rats ◽  
Structure And Function ◽  
Renal Structure ◽  
And Function

scholarly journals Supplementation of Type 1 Diabetic Rats with Carrot Powder Lowers Blood Glucose without Improving Cardiac Structure and Function

2018 ◽  
Vol 23 (2) ◽  
pp. 115-121
Author(s):  
Xavier Lieben Louis ◽  
Pema Raj ◽  
Kathleen J. McClinton ◽  
Liping Yu ◽  
Miyoung Suh ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Diabetic Rats ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Cardiac Structure And Function ◽  
And Function

Discordant Effects of Guanidines on Renal Structure and Function and on Regional Vascular Dysfunction and Collagen Changes in Diabetic Rats

Diabetes ◽  
1997 ◽  
Vol 46 (1) ◽  
pp. 94-106 ◽  
Author(s):  
J. R. Nyengaard ◽  
K. Chang ◽  
S. Berhorst ◽  
K. M. Reiser ◽  
J. R. Williamson ◽  
...  
Keyword(s):  
Vascular Dysfunction ◽  
Diabetic Rats ◽  
Structure And Function ◽  
Renal Structure ◽  
And Function

scholarly journals The effect of aerobic exercise along with resveratrol supplementation on myocardial AMPK and MAFbx gene expression of diabetic rats

2020 ◽  
pp. 150-160
Keyword(s):  
Gene Expression ◽  
Aerobic Exercise ◽  
Aerobic Training ◽  
Myocardial Hypertrophy ◽  
Training Session ◽  
Diabetic Rats ◽  
Structure And Function ◽  
Heart Injury ◽  
And Function

Background and Aim: Diabetes is a metabolic disease that is associated with heart injury. It has been shown that exercise training and resveratrol can improve the cardiac structure and function of diabetic subjects. The aim of the present study was to examine the effect of aerobic training along with resveratrol on gene expression of AMPK and MAFbx on myocardial AMPK and MAFbx gene expression of diabetic rats. Materials and Methods: In this experimental study, 40 males Wistar rats were randomly were divided into 5 groups: control (CN), diabetes (DM), diabetes-Resveratrol (RDM), diabetes-aerobic exercise (TDM), diabetes-aerobic exercise-Resveratrol (RTDM).Training groups have performed a running program on the treadmill for 8 weeks. Resveratrol (20 mg/kg) was injected subcutaneously 8 weeks for RDM and TRDM groups. 48 hours after the last training session, rats were anesthetized. Changes in the expression of AMPK and MAFbx myocardial genes were quantified using real-time PCR methods. Results: The results of the present study showed a reduction in AMPK expression (P < 0.001) and an increase in MAFbx (P < 0.001) in cardiomyocytes in DM groups compared to CN group. AMPK expression was significantly increased in TRDM group compared to DM (p=0.009), RDM (p=0.011) and TDM (p=0.043) groups. MAFbx expression of cardiomyocytes in RDM (p=0.012), TDM (p<0.001) and TRDM (p<0.001) groups had significantly reduction compared to DM group. Also, MAFbx expression was significantly reduction in TRDM groups compared to RDM (p=0.041) groups. Conclusion: Long-term aerobic exercise, with and without resveratrol consumption it may cause to reduce the genomic indicators of atrophy and increase myocardial hypertrophy in diabetic rats. Key Words: AMPK; Diabetic Rats; Exercise; MAFbx; Resveratrol

Sign in / Sign up

Export Citation Format

Share Document