Role of oxidative stress, infection and inflammation in male infertility

Andrologia ◽  
2018 ◽  
Vol 50 (11) ◽  
pp. e13126 ◽  
Author(s):  
Ashok Agarwal ◽  
Mohit Rana ◽  
Emily Qiu ◽  
Hashem AlBunni ◽  
Albert D. Bui ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Male Infertility ◽  
Infection And Inflammation

scholarly journals Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation

2021 ◽  
Vol 28 (4) ◽  
pp. 471-489
Author(s):  
Valeriy A. Chereshnev ◽  
Svetlana V. Pichugova ◽  
Yakov B. Beikin ◽  
Margarita V. Chereshneva ◽  
Angelina I. Iukhta ◽  
...  
Keyword(s):  
Male Infertility ◽  
Reproductive Potential ◽  
Diagnostic Value ◽  
Venous Stasis ◽  
Spermatozoa Motility ◽  
Infection And Inflammation ◽  
Sperm Antigens ◽  
Global Data ◽  
Blood Testis Barrier

According to global data, there is a male reproductive potential decrease. Pathogenesis of male infertility is often associated with autoimmunity towards sperm antigens essential for fertilization. Antisperm autoantibodies (ASAs) have immobilizing and cytotoxic properties, impairing spermatogenesis, causing sperm agglutination, altering spermatozoa motility and acrosomal reaction, and thus preventing ovum fertilization. Infertility diagnosis requires a mandatory check for the ASAs. The concept of the blood–testis barrier is currently re-formulated, with an emphasis on informational paracrine and juxtacrine effects, rather than simple anatomical separation. The etiology of male infertility includes both autoimmune and non-autoimmune diseases but equally develops through autoimmune links of pathogenesis. Varicocele commonly leads to infertility due to testicular ischemic damage, venous stasis, local hyperthermia, and hypoandrogenism. However, varicocelectomy can alter the blood–testis barrier, facilitating ASAs production as well. There are contradictory data on the role of ASAs in the pathogenesis of varicocele-related infertility. Infection and inflammation both promote ASAs production due to “danger concept” mechanisms and because of antigen mimicry. Systemic pro-autoimmune influences like hyperprolactinemia, hypoandrogenism, and hypothyroidism also facilitate ASAs production. The diagnostic value of various ASAs has not yet been clearly attributed, and their cut-levels have not been determined in sera nor in ejaculate. The assessment of the autoimmunity role in the pathogenesis of male infertility is ambiguous, so the purpose of this review is to show the effects of ASAs on the pathogenesis of male infertility.

scholarly journals Role of oxidative stress and antioxidants in male infertility: An interventional study

2019 ◽  
Vol 12 (3) ◽  
pp. 204 ◽  
Author(s):  
Ganeswar Barik ◽  
Latha Chaturvedula ◽  
Zachariah Bobby
Keyword(s):  
Oxidative Stress ◽  
Male Infertility ◽  
Interventional Study

Male infertility: Role of vitamin D and oxidative stress markers

Andrologia ◽  
2021 ◽  
Author(s):  
Maheen Shahid ◽  
Sher Khan ◽  
Mussarat Ashraf ◽  
Hina Akram Mudassir ◽  
Rehana Rehman
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Male Infertility ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
And Oxidative Stress

scholarly journals Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine and Endocrine Deregulation

2021 ◽  
Author(s):  
Valeriy A. Chereshnev ◽  
Svetlana V. Pichugova ◽  
Yakov B. Beikin ◽  
Margarita V. Chereshneva ◽  
Angelina I. Iukhta ◽  
...  
Keyword(s):  
Male Infertility ◽  
Reproductive Potential ◽  
Diagnostic Value ◽  
Venous Stasis ◽  
Spermatozoa Motility ◽  
Infection And Inflammation ◽  
Sperm Antigens ◽  
Global Data ◽  
Blood Testis Barrier

According to global data, there is a male reproductive potential decrease. Pathogenesis of male infertility often is associated with autoimmunity towards sperm antigens essential for fertilization. Antisperm autoantibodies (ASAs) have immobilizing and cytotoxic properties, impairing spermatogenesis, causing sperm agglutination, altering spermatozoa motility and acrosomal reaction, thus preventing ovum fertilization. Infertility diagnosis requires mandatory check for the ASAs. The concept of blood-testis barrier currently is re-formulated with emphasis of informational paracrine and juxtacrine effects, rather than simple anatomical separation. Aetiology of male infertility includes both autoimmune and non-autoimmune diseases, but equally develops through autoimmune links of pathogenesis. Varicocele commonly leads to infertility due to testicular ischemic damage, venous stasis, local hyperthermia, and hypoandrogenism. However, varicocelectomy can alter blood-testis barrier facilitating ASAs production as well. There are contradictory data on the role of ASAs in pathogenesis of varicocele-related infertility. Infection and inflammation both promote ASAs production due to “danger concept” mechanisms and because of antigen mimicry. Systemic pro-autoimmune influences like hyperprolactinemia, hypoandrogenism and hypothyroidism also facilitate ASAs production. Diagnostic value of various ASAs was not yet clearly attributed, and their cut-levels not agreed neither in sera nor in ejaculate. The assessment of the autoimmunity role in pathogenesis of male infertility is ambiguous.

Effects of zinc deficiency on impaired spermatogenesis and male infertility: the role of oxidative stress, inflammation and apoptosis

2018 ◽  
Vol 23 (1) ◽  
pp. 5-16 ◽  
Author(s):  
Asghar Beigi Harchegani ◽  
Heydar Dahan ◽  
Eisa Tahmasbpour ◽  
Hamid Bakhtiari kaboutaraki ◽  
Alireza Shahriary
Keyword(s):  
Oxidative Stress ◽  
Male Infertility ◽  
Zinc Deficiency

Role of oxidative stress and antioxidants in male infertility

2008 ◽  
Vol 180 ◽  
pp. S204
Author(s):  
Rashmi Tomar ◽  
A.K. Jain ◽  
N.K Mohanty ◽  
Banajit Bastia ◽  
S.N Kumar
Keyword(s):  
Oxidative Stress ◽  
Male Infertility
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