Combined effects of chronic hyperglycaemia and oral aluminium intoxication on testicular tissue and some male reproductive parameters in Wistar rats

Andrologia ◽  
2015 ◽  
Vol 48 (7) ◽  
pp. 779-786 ◽  
Author(s):  
O. B. Akinola ◽  
S. A. Biliaminu ◽  
O. G. Adedeji ◽  
B. S. Oluwaseun ◽  
O. M. Olawoyin ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Testicular Tissue ◽  
Combined Effects ◽  
Reproductive Parameters ◽  
Chronic Hyperglycaemia

Cyantraniliprole impairs reproductive parameters by inducing oxidative stress in adult female wistar rats

2021 ◽  
Author(s):  
Suellen Ribeiro da Silva Scarton ◽  
Felipe Tsuzuki ◽  
Marina Trevizan Guerra ◽  
Dayane Priscila dos Santos ◽  
Aldair Casagrande dos Santos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adult Female ◽  
Wistar Rats ◽  
Reproductive Parameters ◽  
Female Wistar Rats

Effects of Prepubertal Exposure to Silver Nanoparticles on Reproductive Parameters in Adult Male Wistar Rats

2013 ◽  
Vol 76 (17) ◽  
pp. 1023-1032 ◽  
Author(s):  
Hanan Khaled Sleiman ◽  
Renata Marino Romano ◽  
Claudio Alvarenga de Oliveira ◽  
Marco Aurelio Romano
Keyword(s):  
Silver Nanoparticles ◽  
Adult Male ◽  
Wistar Rats ◽  
Reproductive Parameters ◽  
Male Wistar Rats

scholarly journals CATALASE 1 GENE EXPRESSION (CAT-1) IN HYPERGLICEMIA INDUCED TESTIS, AS AN ANTIOXIDANT THERAPY INDICATORS

2021 ◽  
Vol 28 (1) ◽  
pp. 53-56
Author(s):  
Ahmad Zulfan ◽  
Nickanor K. R Wonatorey
Keyword(s):  
Gene Expression ◽  
Clinical Study ◽  
Quantitative Pcr ◽  
Wistar Rats ◽  
Testicular Tissue ◽  
Antioxidant Therapy ◽  
Total Rna ◽  
Catalase Gene ◽  
Induction Group

Objective: This study aims to analyze the effects of hyperglycemia status on the function of testicular spermatology, especially CAT-1. Material & Methods: This study was an experimental pre-clinical study. Twenty-seven rats were divided into 3 groups: normal, 2 weeks, and 4 weeks hyperglycemia. The hyperglycemic state in the Wistar rats was induced by Streptozotocin (STZ). All data were collected and analyzed with SPSS 20.0. At two and four weeks, testicular tissue was extracted and it will be processed using the Total RNA Mini Kit FavorPrepTM then quantitative PCR was performed using the SYBR® Fast qPCR Kit. Results: CAT-1 gene expression in the hyperglycemia induction group increased when induced for 2 weeks and again after 4 weeks compared to controls (18.88 ± 4.7 and 21.45 ± 5.52 vs 10.83 ± 3.4). However only induction after 2 weeks was statistically significant (p= 0.021). Conclusion: CAT-1 (Catalase) gene expression has increased in testicular tissue under conditions of hyperglycemia.

Evaluation of reproductive parameters in adult male Wistar rats after subchronic exposure (gavage) to benomyl

1988 ◽  
Vol 25 (3) ◽  
pp. 285-298 ◽  
Author(s):  
Ralph E. Linder ◽  
Georgia L. Rehnberg ◽  
Lillian F. Strader ◽  
Juanita P. Diggs
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Reproductive Parameters ◽  
Subchronic Exposure ◽  
Male Wistar Rats

scholarly journals Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats

2012 ◽  
Vol 63 (3) ◽  
pp. 255-262 ◽  
Author(s):  
Marijana Ćurčić ◽  
Saša Janković ◽  
Vesna Jaćević ◽  
Sanja Stanković ◽  
Slavica Vučinić ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Thyroid Function ◽  
Wistar Rats ◽  
Diphenyl Ether ◽  
Thyroid Stimulating Hormone ◽  
Combined Effects ◽  
Single Substance ◽  
Hormone Homeostasis ◽  
Stimulating Hormone

The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg-1, 7.5 mg kg-1, or 15 mg kg-1 b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg-1, 2000 mg kg-1, or 4000 mg kg-1 b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.

Effects of subchronic exposure to sibutramine and/or rosuvastatin on reproductive parameters of Wistar rats

2016 ◽  
Vol 259 ◽  
pp. S237
Author(s):  
P.V. Silva ◽  
C.S. Borges ◽  
T.L. Pacheco ◽  
T.M. Figueiredo ◽  
J.L. Rosa ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Reproductive Parameters ◽  
Subchronic Exposure

METABOLISM OF [7α-3H]DEHYDROEPIANDROSTERONE AND [4-14C]ANDROSTENEDIONE IN VITRO BY TESTICULAR TISSUE FROM ADULT AND PREPUBERTAL WISTAR RATS

1974 ◽  
Vol 63 (1) ◽  
pp. 149-155 ◽  
Author(s):  
GWEN RICHARDS ◽  
A. MUNRO NEVILLE
Keyword(s):  
Wistar Rats ◽  
Reductase Activity ◽  
Testicular Tissue ◽  
Adult Rat

SUMMARY The metabolism of [7α-3H]dehydroepiandrosterone (DHA) and [4-14C] androstenedione in vitro was investigated in 30-day-old (prepubertal) and adult rat testicular tissue in the presence of cyanoketosteroid, a 5-ene-3β-hydroxysteroid oxidoreductase inhibitor. Whereas both substrates were converted to 5α-reduced steroids by the prepubertal testis, 4-ene-steroid-5α-reductase activity was negligible in the adult gland. Cyanoketosteroid prevented the formation of 5α-reduced steroids from DHA by the prepubertal testis indicating testosterone and androstenedione as intermediates in their production.

scholarly journals The Effect of Intratesticular Injection of Human Adipose-Derived Stem Cell (hADSC) on Testicular Oxidative Stress and Spermatogenesis Process in the Varicocele Rat Model

2021 ◽  
Author(s):  
Safendra Siregar ◽  
Bambang Sasongko Noegroho ◽  
Ricky Adriansjah ◽  
Akhmad Mustafa ◽  
Ananta Bonar
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Wistar Rats ◽  
Histopathological Examination ◽  
Therapy Group ◽  
Intervention Group ◽  
Testicular Tissue ◽  
Control Group ◽  
Group I ◽  
Group Ii

Abstract Introduction: Varicocele is the predominant cause of male infertility and was found in 19% - 41% of men with primary infertility and 45% - 81% of men with secondary infertility. Human adipose Derived Stem Cells (hADSC) can suppress oxidative stress in some oxidative injury model. Therefore, this study would like to investigate the effect of intratesticular hADSC injection on MDA level and spermatogenesis process by histopathological examination in the varicocele rat model.Method: This is an experimental study. A total sampling of 9 male Wistar rats were divided into three groups. Group I consist of 1 Wistar rats without any treatment or model (sham group), group II consist of 4 Wistar rats with varicocele model without hADSC therapy (control group), and group III consist of 4 Wistar rats with varicocele model and were given injections of 1.0x106 hADSC cells intratesticularly 30 days after model was made (therapy group). Testicular tissue was harvested for evaluation. Results: In all varicocele model rats (group II and III), the result of MDA level in therapy group (2.53 mol/liter) was significantly lower than the MDA level in control group (4.43 mol/liter) (p = 0.01). On histopathological examination, the average Johnson's Score in the therapy and control group was 9,77 and 9,18, respectively. The analysis showed Johnson’s score in the intervention group was significantly higher (p = 0.018). Conclusion: Intratesticular injection of hADSC can help reduce MDA levels and improve spermatogenesis process, which is damaged by varicoceles.

scholarly journals Effects of Withania coagulans extract and morphine on spermatogenesis in rats

2021 ◽  
Vol 18 (4) ◽  
pp. 817-822
Author(s):  
Ali Noori ◽  
Leila Amjad ◽  
Fereshteh Yazdani
Keyword(s):  
Body Weight ◽  
Luteinizing Hormone ◽  
Methanol Extract ◽  
Histopathological Examination ◽  
Follicle Stimulating Hormone ◽  
Testicular Tissue ◽  
Reproductive Parameters ◽  
Blood Samples ◽  
Significant Difference ◽  
Sistan And Baluchestan

Purpose: To investigate the comparative effects of Withania coagolans extract and morphine on spermatogenesis in rats Methods: W. coagolans was collected from Sistan and Baluchestan, Iran and 50 and 100 mg/kg body weight doses of methanol extract and 5, 10 and 15 mg/kg body weight doses of morphine were administered parenterally to the rats which were divided into groups. Blood samples were collected and the levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), and testosterone were assayed. The testicular tissue was isolated for histopathological examination. Results: No significant changes were observed in levels of LH, FSH and testosterone in treated groups (p < 0.05). However, there was significant difference between the treated groups for extract plus morphine groups, in terms of the number of spermatogonium, spermatocytes and spermatide variation. Moreover, the results indicate tissue disorders in all groups relative to control. The extract caused more disturbances in spermatogenesis compared to morphine, and appears to improve parameters related to spermatogenesis. Conclusion: The results show that the higher dose of Withania coagolans extract (100 mg/kg) exerts varying effects on reproductive parameters. Moreover, the lower dose of Withania coagolans extract (50 mg/kg) enhanced spermatogenesis while also protecting against the damaging effects of morphine.

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