Blueberries prevent the effect of intermittent hypobaric hypoxia in rat epididymis

Andrologia ◽  
2013 ◽  
Vol 46 (7) ◽  
pp. 766-769 ◽  
Author(s):  
A. B. Zepeda ◽  
G. M. Calaf ◽  
C. A. Figueroa ◽  
J. G. Farías
Keyword(s):  
Hypobaric Hypoxia ◽  
Intermittent Hypobaric Hypoxia ◽  
Rat Epididymis

scholarly journals Effect of Acclimation to Intermittent Hypobaric Hypoxia on NO Homeostasis

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Jae Seung Chang ◽  
Yun Bok Sim ◽  
Jeong Hee Lee ◽  
Sang Seok Nam ◽  
Sub Sunoo ◽  
...  
Keyword(s):  
Hypobaric Hypoxia ◽  
Intermittent Hypobaric Hypoxia

scholarly journals Combined intermittent hypobaric hypoxia and muscle electro-stimulation: a method to increase circulating progenitor cell concentration?

2014 ◽  
Vol 12 (1) ◽  
pp. 174 ◽  
Author(s):  
Luisa Corral ◽  
Casimiro Javierre ◽  
Juan Blasi ◽  
Ginés Viscor ◽  
Antoni Ricart ◽  
...  
Keyword(s):  
Hypobaric Hypoxia ◽  
Progenitor Cell ◽  
Cell Concentration ◽  
Intermittent Hypobaric Hypoxia

The effect of intermittent hypobaric hypoxic exposure and sea level training on submaximal economy in well-trained swimmers and runners

2008 ◽  
Vol 104 (2) ◽  
pp. 328-337 ◽  
Author(s):  
Martin J. Truijens ◽  
Ferran A. Rodríguez ◽  
Nathan E. Townsend ◽  
James Stray-Gundersen ◽  
Christopher J. Gore ◽  
...  
Keyword(s):  
Sea Level ◽  
Repeated Measures ◽  
Hypobaric Hypoxia ◽  
Lactate Concentration ◽  
Hypoxic Exposure ◽  
Double Blind ◽  
Intermittent Hypobaric Hypoxia ◽  
Post Test ◽  
Double Blind Design ◽  
Level Training

To evaluate the effect of intermittent hypobaric hypoxia combined with sea level training on exercise economy, 23 well-trained athletes (13 swimmers, 10 runners) were assigned to either hypobaric hypoxia (simulated altitude of 4,000–5,500 m) or normobaric normoxia (0–500 m) in a randomized, double-blind design. Both groups rested in a hypobaric chamber 3 h/day, 5 days/wk for 4 wk. Submaximal economy was measured twice before (Pre) and after (Post) the treatment period using sport-specific protocols. Economy was estimated both from the relationship between oxygen uptake (V̇o2) and speed, and from the absolute V̇o2 at each speed using sport-specific protocols. V̇o2 was measured during the last 60 s of each (3–4 min) stage using Douglas bags. Ventilation (V̇e), heart rate (HR), and capillary lactate concentration ([La−]) were measured during each stage. Velocity at maximal V̇o2 (velocity at v̇o2max) was used as a functional indicator of changes in economy. The average V̇o2 for a given speed of the Pre values was used for Post test comparison using a two-way, repeated-measures ANOVA. Typical error of measurement of V̇o2 was 4.7% (95% confidence limits 3.6–7.1), 3.6% (2.8–5.4), and 4.2% (3.2–6.9) for speeds 1, 2, and 3, respectively. There was no change in economy within or between groups (ANOVA interaction P = 0.28, P = 0.23, and P = 0.93 for speeds 1, 2, and 3). No differences in submaximal HR, [La−], V̇e, or velocity at V̇o2max were found between groups. It is concluded that 4 wk of intermittent hypobaric hypoxia did not improve submaximal economy in this group of well-trained athletes.

Therapeutic effect of intermittent hypobaric hypoxia on myocardial infarction in rats

2011 ◽  
Vol 106 (3) ◽  
pp. 329-342 ◽  
Author(s):  
Wei-Qing Xu ◽  
Zhuo Yu ◽  
Yan Xie ◽  
Guo-Qian Huang ◽  
Xian-Hong Shu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Therapeutic Effect ◽  
Hypobaric Hypoxia ◽  
Intermittent Hypobaric Hypoxia

Chronic intermittent hypobaric hypoxia decreases β-adrenoceptor activity in right ventricular papillary muscle

2010 ◽  
Vol 298 (4) ◽  
pp. H1267-H1272 ◽  
Author(s):  
Yue Guan ◽  
Lu Gao ◽  
Hui-Jie Ma ◽  
Qian Li ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Action Potential ◽  
Right Ventricular ◽  
Papillary Muscle ◽  
Action Potential Duration ◽  
Adrenergic Receptor ◽  
Hypobaric Hypoxia ◽  
Radioligand Binding ◽  
Ischemia Reperfusion ◽  
Intermittent Hypobaric Hypoxia ◽  
Membrane Bound

Chronic intermittent hypobaric hypoxia (CIHH) has an effective cardiac protection against ischemia-reperfusion injury. However, the underlying mechanisms are not fully known. It has been shown that blockade of β-adrenergic receptor exerts anti-arrhythmic action and improves cardiac remodeling in ischemic myocardium. Thus we determined the influence of CIHH on β-adrenergic receptor activity in right ventricular papillary muscle of rats. We found that the action potential duration in right ventricular papillary muscle was significantly longer in CIHH rats than in control rats. Activation of β-adrenergic receptor with dl-isoproterenol dose-dependently increased action potential duration and the contractility in right ventricular papillary muscle. In CIHH rats, the prolonged effect of dl-isoproterenol on action potential duration and the positive inotropic effect were significantly decreased compared with that in control rats. Furthermore, radioligand-binding experiments revealed that the density and affinity of β-adrenergic receptor in right ventricular myocardium was significantly lower in CIHH rats. In addition, Western blot analysis revealed that the membrane-bound G protein Gsα expression level in cardiac myocardium was significantly lower in CIHH rats than that in control rats. Collectively, these data suggest that CIHH suppresses β-adrenergic receptor action in right ventricular papillary muscle through decreasing receptor density and affinity, as well as membrane-bound Gsα. This mechanism may be involved in the cardiac protective effect of CIHH.

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