Hyperbaric prilocaine vs. hyperbaric bupivacaine for spinal anaesthesia in women undergoing elective caesarean section: a comparative randomised double‐blind study

Anaesthesia ◽  
2021 ◽  
Author(s):  
K. Chapron ◽  
J.‐C. Sleth ◽  
X. Capdevila ◽  
S. Bringuier ◽  
C. Dadure
Keyword(s):  
Caesarean Section ◽  
Spinal Anaesthesia ◽  
Elective Caesarean Section ◽  
Blind Study ◽  
Double Blind Study ◽  
Hyperbaric Bupivacaine ◽  
Double Blind

Efficacy of different infusion rates of oxytocin for maintaining uterine tone during elective caesarean section: A randomised double blind trial

2021 ◽  
pp. 0310057X2098448
Author(s):  
Medha Mohta ◽  
Rohit B Chowdhury ◽  
Asha Tyagi ◽  
Rachna Agarwal
Keyword(s):  
Caesarean Section ◽  
Blood Loss ◽  
Spinal Anaesthesia ◽  
Postpartum Haemorrhage ◽  
Elective Caesarean Section ◽  
Double Blind Study ◽  
Double Blind ◽  
Estimated Blood Loss ◽  
Significant Difference ◽  
Oxytocin Infusion

Most research in this field has focused on finding oxytocin doses for initiating uterine contractions. Only limited data are available regarding the optimal rate of oxytocin infusion to maintain adequate uterine tone. This randomised, double blind study included 120 healthy term pregnant patients with uncomplicated, singleton pregnancy undergoing elective caesarean section under spinal anaesthesia. Following an initial 1 IU bolus, the patients received oxytocin infusion at 1.25 IU/hour (group 1.25), 2.5 IU/hour (group 2.5) or 5.0 IU/hour (group 5) for four hours. Uterine tone was assessed as adequate or inadequate at various intervals. If found inadequate, additional uterotonics were administered. Estimated blood loss was mean (standard deviation) 499 (172) ml, 454 (117) ml and 402 (151) ml in groups 1.25, 2.5 and 5, respectively ( P value groups 1.25 versus 5 = 0.012). Oxytocin infusion at 5 IU/hour resulted in a significantly lower incidence of minor postpartum haemorrhage, defined as blood loss greater than 500 ml, than 1.25 IU/hour ( P = 0.009). No patient had major/severe haemorrhage (>1000 ml blood loss). No significant difference was seen in haemoglobin levels ( P = 0.677) and uterine tone. Fifteen, six and nine patients, respectively, required additional oxytocin ( P = 0.151). The incidence of tachycardia ( P = 0.726), hypotension ( P = 0.321) and nausea/vomiting ( P = 0.161) was comparable. To conclude, 5 IU/hour was more effective than 1.25 IU/hour in reducing total blood loss and the incidence of minor postpartum haemorrhage. Thus 5 IU/hour appears to be an optimal oxytocin infusion rate following 1 IU slow intravenous oxytocin injection for the maintenance of adequate uterine contraction in patients undergoing elective caesarean section under spinal anaesthesia.

scholarly journals Effect of Ondansetron on the Occurrence of Hypotension and on Neonatal Parameters during Spinal Anesthesia for Elective Caesarean Section: A Prospective, Randomized, Controlled, Double-Blind Study

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Walid Trabelsi ◽  
Chihebeddine Romdhani ◽  
Haythem Elaskri ◽  
Walid Sammoud ◽  
Mohamed Bensalah ◽  
...  
Keyword(s):  
Caesarean Section ◽  
Spinal Anesthesia ◽  
Elective Caesarean Section ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Randomized Controlled

To prevent hypotension during spinal anesthesia for caesarean section, we assessed IV ondansetron of invasive maternal hemodynamic and fetal gazometric parameters.

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