A pilot randomised controlled trial of the management of systolic blood pressure during endovascular thrombectomy for acute ischaemic stroke

Anaesthesia ◽  
2019 ◽  
Vol 75 (6) ◽  
pp. 739-746 ◽  
Author(s):  
C. Deng ◽  
D. Campbell ◽  
W. Diprose ◽  
C. Eom ◽  
K. Wang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Randomised Controlled Trial ◽  
Systolic Blood Pressure ◽  
Ischaemic Stroke ◽  
Acute Ischaemic Stroke ◽  
Controlled Trial ◽  
Endovascular Thrombectomy ◽  
Pilot Randomised Controlled Trial ◽  
Randomised Controlled

Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

The Lancet ◽  
2020 ◽  
Vol 395 (10227) ◽  
pp. 878-887 ◽  
Author(s):  
Michael D Hill ◽  
Mayank Goyal ◽  
Bijoy K Menon ◽  
Raul G Nogueira ◽  
Ryan A McTaggart ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Ischaemic Stroke ◽  
Acute Ischaemic Stroke ◽  
Controlled Trial ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Randomised Controlled

scholarly journals Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial

2019 ◽  
Vol 18 (4) ◽  
pp. 338-347 ◽  
Author(s):  
Andrei V Alexandrov ◽  
Martin Köhrmann ◽  
Lauri Soinne ◽  
Georgios Tsivgoulis ◽  
Andrew D Barreto ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Ischaemic Stroke ◽  
Acute Ischaemic Stroke ◽  
Controlled Trial ◽  
Phase 3 ◽  
Double Blind ◽  
Safety And Efficacy ◽  
Randomised Controlled

scholarly journals Rehabilitation nursing for motor functional recovery of acute ischaemic stroke: study protocol for a randomised controlled trial

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e037391
Author(s):  
Jianmiao Wang ◽  
Yuanyuan Chen ◽  
Yuping Zhang ◽  
Mei Li ◽  
Jingfen Jin
Keyword(s):  
Randomised Controlled Trial ◽  
Ischaemic Stroke ◽  
Outcome Measures ◽  
Functional Recovery ◽  
Acute Ischaemic Stroke ◽  
Controlled Trial ◽  
Secondary Outcome ◽  
Control Group ◽  
Functional Impairments ◽  
Randomised Controlled

IntroductionStroke is the second-leading cause of death and disability in the world, and patients with stroke often suffer from functional impairments and need rehabilitation. Notably, there is much evidence that rehabilitation can lead to better mortality and morbidity outcomes. The evidence for the effectiveness of rehabilitation nursing, however, is limited. Thus, this study seeks to explore whether rehabilitation nursing is not inferior to usual rehabilitation for motor functional recovery in patients with acute ischaemic stroke.Methods and analysisWe will conduct an assessor-blinded parallel randomised controlled trial of patients who meet the inclusion criteria after stratification by weighted corticospinal tract lesion load. The experimental group will receive rehabilitation nursing by trained and qualified nurses (seven consecutive days, two sessions per day, 30 min each session). The control group will receive usual rehabilitation provided by therapists (seven consecutive days, two sessions per day, 30 min each session). The primary outcome measures are the Motor Assessment Scale, the Fugl-Meyer Assessment and the Action Research Arm Test. The secondary outcome measures are the modified Rankin Scale, the modified Barthel Index and the National Institute of Health Stroke Scale. Primary and secondary outcome assessment will be performed before and after the intervention, and secondary outcome be assessed at 4 and 12 weeks follow-up. We will recruit 224 patients within a period of 12–18 months from a hospital in southeastern China.Ethics and disseminationThe study was approved by the Human Research Ethics Committee from the corresponding author’s hospital (approval Number is Ethical Review Study No. 2018 - 112). Peer-reviewed journals and presentations at national and international conferences will be used to disseminate the results.Trial registration numberNCT03702452.

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