scholarly journals Clinical evaluation of a novel technology for non-invasive and continuous measurement of plasma haemoglobin concentration

Anaesthesia ◽  
2015 ◽  
Vol 70 (10) ◽  
pp. 1165-1170 ◽  
Author(s):  
A. J. Broderick ◽  
F. Desmond ◽  
G. Leen ◽  
G. Shorten
Keyword(s):  
Clinical Evaluation ◽  
Continuous Measurement ◽  
Haemoglobin Concentration ◽  
Non Invasive ◽  
Plasma Haemoglobin ◽  
Novel Technology

The Utility of Non-invasive Tests for Detection of Previous Proximal-vein Thrombosis

1995 ◽  
Vol 73 (04) ◽  
pp. 592-596 ◽  
Author(s):  
Sabina Villalta ◽  
Paolo Prandoni ◽  
Alberto Cogo ◽  
Paola Bagatella ◽  
Andrea Piccioli ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Femoral Vein ◽  
Clinical Score ◽  
Diagnostic Methods ◽  
Popliteal Vein ◽  
Venous Reflux ◽  
Study Objective ◽  
Vein Thrombosis ◽  
Non Invasive ◽  
The Common

SummaryBackground. Despite the availability of several diagnostic methods for the detection of deep-vein thrombosis (DVT), the identification of previous episodes of DVT remains a diagnostic challenge.Study objective. To assess the reliability of a combination of a standardized clinical score with three non-invasive tests: compression ultrasonography (CUS), Doppler ultrasound (DUS), and photoplethysmography (PPG), in determining the presence or the absence of previous proximal DVT.Methods. One hundred consecutive unselected outpatients were identified, who had undergone contrast venography six to nine years previously because of the clinical suspicion of DVT (confirmed in 43). They were blindly reinvestigated by a panel of trained operators unaware of venography results. They underwent a clinical evaluation of the lower limb, by applying a standardized score to five symptoms and six signs (grading each item from 0 to 3); a PPG test to determine the venous refilling time; a DUS test to determine the venous reflux separately in the common femoral and the popliteal vein; and a CUS test to determine vein compressibility in the same regions.Results. An abnormal CUS test and/or the demonstration of venous reflux in the popliteal region and/or a high clinical score (≥ 8) identified twenty-four of the 43 (56%) DVT + patients with a specificity of 89%. The combination of normal CUS with the absence of venous reflux in both the common femoral and popliteal vein and a low clinical score excluded previous thrombosis in 45 (79%) of the 57 DVT- patients (negative predictive value, 78%). Abnormal venous reflux in the isolated common femoral vein did not reliably predict the presence or absence of previous DVT. However, this occurred in only 13 (13%) patients. The PPG determination of venous refilling time did not improve the results obtained with the other tests.Conclusions. The combination of a standardized clinical evaluation with the results of CUS and DUS can reliably diagnose or exclude previous proximal-vein thrombosis in almost 90% of patients with previous episodes of suspected DVT.

scholarly journals Anaemia and Haemoglobin Status: A New Concept and a New Method of Assessment

1996 ◽  
Vol 17 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Rainer Gross ◽  
Marcus Gliwitzki ◽  
Patrick Gross ◽  
Klaus Frank
Keyword(s):  
Oxygen Supply ◽  
Haemoglobin Concentration ◽  
Tissue Level ◽  
Intervention Strategies ◽  
Blood Oxygenation ◽  
The Body ◽  
Non Invasive ◽  
Method Of Assessment ◽  
The Impact ◽  
Tissue Oxygen Supply

Traditionally, anaemia has been determined and interpreted by the magnitude and severity of iron deficiency and the impact of intervention strategies. Internationally, it is defined as a state in which the quality and/or quantity of circulating red cells are reduced below a normal level The body employs several mechanisms during the development of anaemia to maintain the oxygen supply to the tissues. Thus, applying any quantitative cut-off point as an indicator for anaemia may lead to misclassification, since haemoglobin concentration does not necessarily reflect the level of tissue oxygen supply. Ideally, an assessment strategy should be able to determine both the degree of haemoglobin oxygenation and the haemoglobin concentration at a tissue level. The Erlangen microlight-guide spectrophotometer is a non-invasive instrument that can assess both capillary blood oxygenation and relative haemoglobin concentration.

Prospective clinical evaluation of Momguard non-invasive prenatal test in 1011 Korean high-risk pregnant women

2019 ◽  
Vol 40 (8) ◽  
pp. 1090-1095
Author(s):  
Hae-Jin Hu ◽  
Mi-Young Lee ◽  
Dae-Yeon Cho ◽  
Mijin Oh ◽  
Young-Jun Kwon ◽  
...  
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Clinical Evaluation ◽  
Non Invasive ◽  
Prenatal Test

Clinical Evaluation of the Nellcor N-Cat N500 Non-Invasive Blood Pressure Monitor

1997 ◽  
Vol 22 (1) ◽  
pp. 41-48
Author(s):  
D. John Doyle ◽  
Ramiro Arellano ◽  
Kevin F. OʼGrady ◽  
H. Nierenberg ◽  
S. Carroll ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Clinical Evaluation ◽  
Blood Pressure Monitor ◽  
Pressure Monitor ◽  
Invasive Blood Pressure ◽  
Non Invasive

scholarly journals Comparison of four methods to measure haemoglobin concentrations in whole blood donors (COMPARE): a diagnostic accuracy study

2020 ◽  
Author(s):  
Steven Bell ◽  
Michael Sweeting ◽  
Anna Ramond ◽  
Ryan Chung ◽  
Stephen Kaptoge ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Donors ◽  
Blood Donation ◽  
Haemoglobin Concentration ◽  
Reference Standard ◽  
Non Invasive ◽  
Haematology Analyser ◽  
Haemoglobin Measurement ◽  
Accuracy Study ◽  
Sensitivity Specificity

SUMMARYObjectiveTo compare four haemoglobin measurement methods in whole blood donors.BackgroundTo safeguard donors, blood services measure haemoglobin concentration in advance of each donation. NHS Blood and Transplant’s (NHSBT) usual method has been capillary gravimetry (copper sulphate), followed by venous HemoCue® (spectrophotometry) for donors failing gravimetry. However, gravimetry/venous HemoCue® results in 10% of donors being inappropriately bled (i.e., with haemoglobin values below the regulatory threshold).MethodsThe following were compared in 21,840 blood donors (aged ≥18 years) recruited from 10 mobile centres of NHSBT in England, with each method compared with the Sysmex XN-2000 haematology analyser, the reference standard: 1) gravimetry/venous HemoCue®; 2) “post donation” approach, i.e., estimating current haemoglobin concentration from that measured by a haematology analyser at a donor’s most recent prior donation; 3) capillary HemoCue®; and 4) non-invasive spectrometry (MBR Haemospect® or Orsense NMB200®). We assessed each method for sensitivity; specificity; proportion of donors who would have been inappropriately bled, or rejected from donation (“deferred”) incorrectly; and test preference.ResultsCompared with the reference standard, the methods ranged in test sensitivity from 17.0% (MBR Haemospect®) to 79.0% (HemoCue®) in men, and from 19.0% (MBR Haemospect®) to 82.8% (HemoCue®) in women. For specificity, the methods ranged from 87.2% (MBR Haemospect®) to 99.9% (gravimetry/venous HemoCue®) in men, and from 74.1% (Orsense NMB200®) to 99.8% (gravimetry/venous HemoCue®) in women. The proportion of donors who would have been inappropriately bled ranged from 2.2% in men for HemoCue® to 18.9% in women for MBR Haemospect®. The proportion of donors who would have been deferred incorrectly with haemoglobin concentration above the minimum threshold ranged from 0.1% in men for gravimetry/venous HemoCue® to 20.3% in women for OrSense®. Most donors preferred non-invasive spectrometry.ConclusionIn the largest study reporting head-to-head comparisons of four methods to measure haemoglobin prior to blood donation, our results support replacement of venous HemoCue® with the capillary HemoCue® when donors fail gravimetry. These results have had direct translational implications for NHS Blood and Transplant in England.

scholarly journals An Evaluation of the Levels of Subclinical Malaria Infection and Haemolysis among Residents of Opobo, Rivers State, Nigeria

2020 ◽  
pp. 54-62
Author(s):  
Evelyn Mgbeoma Eze ◽  
Serekara Gideon Christian ◽  
Victoria Samuel Jaja ◽  
Felix Eedee Konne
Keyword(s):  
Malaria Infection ◽  
Malaria Parasite ◽  
Haemoglobin Concentration ◽  
Parasite Infection ◽  
Malaria Parasites ◽  
Statistical Significant Difference ◽  
Plasma Haemoglobin ◽  
Malaria Parasite Infection ◽  
Significant Difference ◽  
Rivers State

Aim: The study was aimed at evaluating the levels of subclinical malaria infection and haemolysis among the residents of Opobo, Rivers State, Nigeria. Study Design: A cross sectional study design was used. The subjects were grouped into males and females and comparisons were made between positive and negative subjects of the same gender and positive subjects of different gender. Place and Duration of Study: The study area was Opobo Town in Opobo/Nkoro Local Government Area of Nigeria. The study was carried out within August 2nd to August 26th, 2019 and a total of 89 apparently healthy subjects were recruited, 35 males and 54 females, aged between 16 – 70 years. Methodology: Malaria parasite identification was done by thick and thin film using Giemsa’s stain, packed cell volume was by microhaematocrit method, plasma haemoglobin concentration and whole blood haemoglobin concentration was determined by cyanmethaemoglobin method. Results: The result revealed a total of 24.72% positivity and 75.28% negativity for malaria parasite infection. Among the males, 17.14% positivity and 82.86% negativity for malaria parasite infection were observed while that of the females was 20.37% positivity and 79.63% negativity. In comparison of the studied parameters made between females infected with malaria parasites and those that were not infected with malaria parasites, there was no statistical significant difference at p<0.05 in plasma haemoglobin and percentage haemolysis. In comparison of the studied parameters between males infected with malaria parasites and those not infected with malaria parasites, there was no statistical significant difference in plasma haemoglobin and percentage haemolysis. On gender based comparison, there was also no statistical significant difference in level haemolysis. Conclusion: The study has revealed a prevalence rate of 24.72% for subclinical malaria infection and the percentage haemolysis of red blood cells in malaria infected subjects residing in Opobo Town compared to subjects without malaria parasite was not statistically significant. Based on gender difference, males were affected more than females, but the level of red blood cell haemolysis was not statistically significant after comparison.

scholarly journals Current concepts of perioperative monitoring in high-risk surgical patients: a review

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Paolo Aseni ◽  
Stefano Orsenigo ◽  
Enrico Storti ◽  
Marco Pulici ◽  
Sergio Arlati
Keyword(s):  
High Risk ◽  
Clinical Evaluation ◽  
Hemodynamic Monitoring ◽  
Perioperative Complications ◽  
Surgical Patients ◽  
Major Surgery ◽  
Main Task ◽  
Evaluation Tool ◽  
Non Invasive ◽  
Number Of Patients

Abstract A substantial number of patients are at high-risk of intra- or post-operative complications or both. Most perioperative deaths are represented by patients who present insufficient physiological reserve to meet the demands of major surgery. Recognition and management of critical high-risk surgical patients require dedicated and effective teams, capable of preventing, recognize, start treatment with adequate support in time to refer patients to the satisfactory ICU level provision. The main task for health-care planners and managers is to identify and reduce this severe risk and to encourage patient’s safety practices. Inadequate tissue perfusion and decreased cellular oxygenation due to hypovolemia, heart dysfunction, reduced cardiovascular reserve, and concomitant diseases are the most common causes of perioperative complications. Hemodynamic, respiratory and careful sequential monitoring have become essential aspects of the clinical practice both for surgeons and intensivists. New monitoring techniques have changed significantly over the past few years and are now able to rapidly identify shock states earlier, define the etiology, and monitor the response to different therapies. Many of these techniques are now minimally invasive or non-invasive. Advanced hemodynamic and respiratory monitoring combines invasive, non-invasive monitoring skills. Non-invasive ultrasound has emerged during the last years as an essential operative and perioperative evaluation tool, and its use is now rapidly growing. Perioperative management guided by appropriate sequential clinical evaluation combined with respiratory and hemodynamic monitoring is an established tool to help clinicians to identify those patients at higher risk in the attempt to reduce the complications rate and potentially improve patient outcomes. This review aims to provide an update of currently available standard concepts and evolving technologies of the various respiratory and hemodynamic monitoring systems for the high-risk surgical patients, highlighting their potential usefulness when integrated with careful clinical evaluation.

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