scholarly journals Bradykinin and cysteinyl leukotriene concentrations in cell-salvaged blood before and after passage through negatively charged filters during clinical use in cancer patients: a pilot study

Anaesthesia ◽  
2015 ◽  
Vol 70 (9) ◽  
pp. 1066-1072 ◽  
Author(s):  
S. J. Catling ◽  
C. A. Thornton ◽  
I. T. Russell
Keyword(s):  
Pilot Study ◽  
Cancer Patients ◽  
Clinical Use ◽  
Cysteinyl Leukotriene ◽  
Before And After

scholarly journals Sexual organ-sparing with hydrogel spacer injections for rectal cancer radiotherapy: a feasibility pilot study

2021 ◽  
pp. 20200931
Author(s):  
Vérane Achard ◽  
Frederic Ris ◽  
Michel Rouzaud ◽  
Giacomo Puppa ◽  
Nicolas C Buchs ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Pilot Study ◽  
Cancer Patients ◽  
Curative Surgery ◽  
Sexual Organ ◽  
Before And After ◽  
Dosimetric Study ◽  
Organ Sparing ◽  
Radiotherapy Dose ◽  
Dose Levels

Objectives: The aim of this pilot study was to investigate in two rectal cancer patients undergoing neoadjuvant chemo-radiotherapy (nCRT) the implant feasibility and dosimetric benefit in sexual organ-sparing of an injectable, absorbable, radiopaque hydrogel spacer. Methods: Two rectal cancer patients (one male and one female) underwent hydrogel implant between rectum and vagina/prostate before nCRT and curative surgery. A CT scan was performed before and after injection and a comparative dosimetric study was performed testing a standard (45/50 Gy) and a dose escalated (46/55.2 Gy) schedule. Results: In both patients, the spacer implant in the recto-prostatic or recto-vaginal space was feasible and well tolerated. For the male, the dosimetric benefit with spacer was minimal for sexual organs. For the female however, doses delivered to the vagina were significantly reduced with spacer with a mean reduction of more than 5 Gy for both regimens. Conclusions: For organ preservation protocols and selected sexually active female patients, use of hydrogel spacers can be considered to spare sexual organs from the high radiotherapy dose levels. Advances in knowledge: For females with advanced rectal tumor, a spacer implant between the rectum and the vagina before nCRT is feasible and reduces doses delivered to the vagina.

scholarly journals Metabolic Profiles of Whole Serum and Serum-Derived Exosomes Are Different in Head and Neck Cancer Patients Treated by Radiotherapy

2020 ◽  
Vol 10 (4) ◽  
pp. 229
Author(s):  
Anna Wojakowska ◽  
Aneta Zebrowska ◽  
Agata Skowronek ◽  
Tomasz Rutkowski ◽  
Krzysztof Polanski ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Energy Metabolism ◽  
Pilot Study ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Gas Chromatography Mass Spectrometry ◽  
Serum Samples ◽  
Before And After ◽  
And Control

Background: In general, the serum metabolome reflects the patient’s body response to both disease state and implemented treatment. Though serum-derived exosomes are an emerging type of liquid biopsy, the metabolite content of these vesicles remains under researched. The aim of this pilot study was to compare the metabolite profiles of the whole serum and serum-derived exosomes in the context of differences between cancer patients and healthy controls as well as patients’ response to radiotherapy (RT). Methods: Serum samples were collected from 10 healthy volunteers and 10 patients with head and neck cancer before and after RT. Metabolites extracted from serum and exosomes were analyzed by the gas chromatography–mass spectrometry (GC–MS). Results: An untargeted GC–MS-based approach identified 182 and 46 metabolites in serum and exosomes, respectively. Metabolites that differentiated cancer and control samples, either serum or exosomes, were associated with energy metabolism. Serum metabolites affected by RT were associated with the metabolism of amino acids, sugars, lipids, and nucleotides. Conclusions: cancer-related features of energy metabolism could be detected in both types of specimens. On the other hand, in contrast to RT-induced changes observed in serum metabolome, this pilot study did not reveal a specific radiation-related pattern of exosome metabolites.

Exercise capacity before and after an 8-week multidisciplinary inpatient rehabilitation program in lung cancer patients: A pilot study

Lung Cancer ◽  
2006 ◽  
Vol 52 (2) ◽  
pp. 257-260 ◽  
Author(s):  
Martijn A. Spruit ◽  
Paul P. Janssen ◽  
Sonja C.P. Willemsen ◽  
Monique M.H. Hochstenbag ◽  
Emiel F.M. Wouters
Keyword(s):  
Lung Cancer ◽  
Pilot Study ◽  
Cancer Patients ◽  
Exercise Capacity ◽  
Inpatient Rehabilitation ◽  
Rehabilitation Program ◽  
Lung Cancer Patients ◽  
Before And After
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