scholarly journals Are current skin antisepsis guidelines too superficial?

Anaesthesia ◽  
2015 ◽  
Vol 70 (5) ◽  
pp. 634-634 ◽  
Author(s):  
D. Stanley
Keyword(s):  
Skin Antisepsis

Skin antisepsis survey in Australia-New Zealand neonatal nurseries

2013 ◽  
Vol 49 (7) ◽  
pp. 601-602 ◽  
Author(s):  
Dharmesh Shah ◽  
Mark Tracy
Keyword(s):  
New Zealand ◽  
Skin Antisepsis

scholarly journals Safety guideline: skin antisepsis for central neuraxial blockade

Anaesthesia ◽  
2014 ◽  
Vol 69 (11) ◽  
pp. 1279-1286 ◽  
Author(s):  
◽  
J. P Campbell ◽  
F. Plaat ◽  
M. R. Checketts ◽  
D. Bogod ◽  
...  
Keyword(s):  
Neuraxial Blockade ◽  
Skin Antisepsis

scholarly journals Clinical application of skin antisepsis using aqueous olanexidine: a scoping review

2022 ◽  
Vol 9 (1) ◽  
Author(s):  
Yutaro Shinzato ◽  
Eiryu Sakihara ◽  
Yuki Kishihara ◽  
Masahiro Kashiura ◽  
Hideto Yasuda ◽  
...  
Keyword(s):  
Clinical Application ◽  
Scoping Review ◽  
Skin Antisepsis

scholarly journals Povidone-iodine-alcohol is superior to chlorhexidine-alcohol in its antimicrobial efficacy on the anaerobic microbial flora in surgical skin preparation of the shoulder region

2019 ◽  
Author(s):  
Dorothea Dörfel ◽  
Georg Daeschlein ◽  
Matthias Maiwald ◽  
Gerald Müller ◽  
Robert Hudek ◽  
...  
Keyword(s):  
Povidone Iodine ◽  
Surgical Site Infections ◽  
Shoulder Surgery ◽  
Skin Microbiome ◽  
Negative Effects ◽  
Skin Preparation ◽  
Prolonged Contact ◽  
Skin Flora ◽  
Cutibacterium Acnes ◽  
Skin Antisepsis

Abstract Background: Cutibacterium acnes is part of the anaerobic skin microbiome and resides in deeper skin layers. The organism is an important agent of surgical site infections (SSI), particularly in shoulder surgery, and is difficult to target with skin antisepsis. We hypothesized that prolonged preparation with an agent that penetrates deeper into the skin is more effective in shoulder surgery. Thus, we compared two different classes of antiseptics, each combined with alcohol, and each applied with two different contact times. Methods: Shoulders of 16 healthy volunteers were treated for 2.5 min (standard) or 30 min (prolonged) with alcohol-based chlorhexidine (CHG-ALC; 2% w/v CHG, 55% w/v [70% v/v] 2-propanol) or alcohol-based povidone iodine (PVP-I-ALC; 3.24% w/v PVP-I, 38.9% w/v 2-propanol, 37.3% w/v ethanol). Skin sites were sampled before, immediately after, and 3 h after treatment. Results: Aerobic skin flora was reduced more effectively by PVP-I-ALC than by CHG-ALC after 2.5 min and immediate sampling, but not after prolonged contact times and 3-h sampling. Anaerobic flora was reduced more effectively by PVP-I-ALC than by CHG-ALC after standard and prolonged contact times and immediate sampling, but not after 3-h sampling. None of the volunteers reported negative effects from skin antisepsis. Conclusions: PVP-I-ALC is more efficacious than CHG-ALC for topical skin antisepsis regarding the anaerobic flora on the skin of the shoulder. Standard and prolonged contact times demonstrated superiority for PVP-I-ALC for samples taken immediately, but missed significance 3 h after application. The clinical relevance of these findings should be studied with SSI as an endpoint.

scholarly journals Penetration of Chlorhexidine into Human Skin

2008 ◽  
Vol 52 (10) ◽  
pp. 3633-3636 ◽  
Author(s):  
T. J. Karpanen ◽  
T. Worthington ◽  
B. R. Conway ◽  
A. C. Hilton ◽  
T. S. J. Elliott ◽  
...  
Keyword(s):  
Human Skin ◽  
High Performance ◽  
Skin Permeation ◽  
Full Thickness ◽  
Alternative Strategies ◽  
Thickness Skin ◽  
Skin Antisepsis ◽  
Permeation Studies ◽  
Franz Diffusion Cells

ABSTRACT This study evaluated a model of skin permeation to determine the depth of delivery of chlorhexidine into full-thickness excised human skin following topical application of 2% (wt/vol) aqueous chlorhexidine digluconate. Skin permeation studies were performed on full-thickness human skin using Franz diffusion cells with exposure to chlorhexidine for 2 min, 30 min, and 24 h. The concentration of chlorhexidine extracted from skin sections was determined to a depth of 1,500 μm following serial sectioning of the skin using a microtome and analysis by high-performance liquid chromatography. Poor penetration of chlorhexidine into skin following 2-min and 30-min exposures to chlorhexidine was observed (0.157 ± 0.047 and 0.077 ± 0.015 μg/mg tissue within the top 100 μm), and levels of chlorhexidine were minimal at deeper skin depths (less than 0.002 μg/mg tissue below 300 μm). After 24 h of exposure, there was more chlorhexidine within the upper 100-μm sections (7.88 ± 1.37 μg/mg tissue); however, the levels remained low (less than 1 μg/mg tissue) at depths below 300 μm. There was no detectable penetration through the full-thickness skin. The model presented in this study can be used to assess the permeation of antiseptic agents through various layers of skin in vitro. Aqueous chlorhexidine demonstrated poor permeation into the deeper layers of the skin, which may restrict the efficacy of skin antisepsis with this agent. This study lays the foundation for further research in adopting alternative strategies for enhanced skin antisepsis in clinical practice.

Skin antisepsis guidelines - time to rethink the ‘rapid sequence spinal’?

Anaesthesia ◽  
2015 ◽  
Vol 70 (3) ◽  
pp. 366-367 ◽  
Author(s):  
B. Parsons ◽  
S. Saha
Keyword(s):  
Rapid Sequence ◽  
Skin Antisepsis

Safety of aqueous chlorhexidine gluconate for skin antisepsis in VLBW infants

2011 ◽  
Vol 87 ◽  
pp. S89
Author(s):  
Maria Grazia Capretti ◽  
Marica Spinelli ◽  
Elisabetta Tridapalli ◽  
Santo Arcuri ◽  
Anna Malavolti ◽  
...  
Keyword(s):  
Chlorhexidine Gluconate ◽  
Vlbw Infants ◽  
Skin Antisepsis
Sign in / Sign up

Export Citation Format

Share Document