scholarly journals NK cells and Lipoxin A 4 promote resolution of eosinophilic inflammation after nasal allergen challenge

Allergy ◽  
2021 ◽  
Author(s):  
Anh Poirot ◽  
Guillaume Wacht ◽  
Lehalle Christine ◽  
Philippe Saas ◽  
Nelly Frossard ◽  
...  
Keyword(s):  
Nk Cells ◽  
Allergen Challenge ◽  
Eosinophilic Inflammation ◽  
Nasal Allergen Challenge

scholarly journals NK cells and Lipoxin A 4 promote resolution of eosinophilic inflammation after nasal allergen challenge

2021 ◽  
Author(s):  
Anh Poirot ◽  
Guillaume Wacht ◽  
Lehalle Christine ◽  
Philippe Saas ◽  
Nelly Frossard ◽  
...  
Keyword(s):  
Nk Cells ◽  
Allergen Challenge ◽  
Eosinophilic Inflammation ◽  
Nasal Allergen Challenge

scholarly journals NK cells and Lipoxin A4 promote resolution of eosinophilic inflammation after nasal allergen challenge

2021 ◽  
Author(s):  
Anh Poirot ◽  
Guillaume Wacht ◽  
Lehalle Christine ◽  
Philippe Saas ◽  
Nelly Frossard ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Nk Cells ◽  
Airway Inflammation ◽  
Grass Pollen ◽  
In Vitro Release ◽  
Allergen Challenge ◽  
In Vitro Assays ◽  
Eosinophilic Inflammation ◽  
Eosinophil Apoptosis

Background: Resolution of inflammation is now recognized as a tightly regulated and active process. Lipoxins (LX) are lead members of a larger family of specialized pro-resolving mediators with unique anti-inflammatory and pro-resolving properties. Recent studies implicated natural killer (NK) cells in the resolution of allergic airway inflammation, notably in promoting eosinophil apoptosis. The aim of the study was to better understand the pro-resolving actions of NK cells and LXA4 during allergic eosinophilic airway inflammation. Methods: 20 subjects with grass pollen allergic rhinitis were included. A nasal provocation test with either a single grass pollen allergen threshold dose or diluent was used. Nasal lavage fluid and cells were collected at baseline and at different time points after challenge. For in vitro assays, eosinophils were incubated with NK cells. Results: We observed that NK cells were recruited to the nasal mucosa shortly after the initiation of the allergic inflammatory response. This recruitment correlated with eosinophilic inflammation. In vitro assays demonstrated that direct contact and a combined action of CD56bright and CD56dim NK cells were needed to promote autologous eosinophil apoptosis. We furthermore observed that local LXA4 production correlated with the peak of neutrophil nasal mucosal infiltration, suggesting a potential role of neutrophils in LXA4 biosynthesis during the early phase of the allergic inflammatory response. Last, LXA4 appeared as essential to inhibit the in vitro release of eosinophil superoxide triggered by NK cells. Conclusion: Together, these findings indicate a synergistic role for NK cells and LXA4 in the resolution of allergic eosinophilic inflammation.

Unilateral nasal allergen challenge leads to bilateral release of prostaglandin D2

1996 ◽  
Vol 26 (4) ◽  
pp. 371-378 ◽  
Author(s):  
M. WAGENMANN ◽  
F. M. BAROODY ◽  
M. DESROSIERS ◽  
W. C. HUBBARD ◽  
S. FORD ◽  
...  
Keyword(s):  
Allergen Challenge ◽  
Prostaglandin D2 ◽  
Nasal Allergen Challenge

Development of nasal allergen challenge with cockroach in children with asthma

2021 ◽  
Author(s):  
Amanda K. Rudman Spergel ◽  
Michelle L. Sever ◽  
Jacqueline Johnson ◽  
Michelle A. Gill ◽  
Veronique Schulten ◽  
...  
Keyword(s):  
Allergen Challenge ◽  
Children With Asthma ◽  
Nasal Allergen Challenge

Leukotriene B4 is essential for selective eosinophil recruitment following allergen challenge of CD4+ cells in a model of chronic eosinophilic inflammation

Life Sciences ◽  
2008 ◽  
Vol 83 (5-6) ◽  
pp. 214-222 ◽  
Author(s):  
Alessandra Bonacini Cheraim ◽  
Pedro Xavier-Elsas ◽  
Sandra Helena Penha de Oliveira ◽  
Tiago Batistella ◽  
Momtchilo Russo ◽  
...  
Keyword(s):  
Allergen Challenge ◽  
Leukotriene B4 ◽  
Eosinophilic Inflammation ◽  
Cd4 Cells ◽  
Eosinophil Recruitment

Comparison of allergic rhinitis outcomes of the environmental exposure unit and nasal allergen challenge model

2019 ◽  
Vol 123 (1) ◽  
pp. 105-106.e1 ◽  
Author(s):  
Mark W. Tenn ◽  
Lisa M. Steacy ◽  
Daniel E. Adams ◽  
Terry J. Walker ◽  
Anne K. Ellis
Keyword(s):  
Allergic Rhinitis ◽  
Environmental Exposure ◽  
Allergen Challenge ◽  
Environmental Exposure Unit ◽  
Nasal Allergen Challenge

scholarly journals Effects of Combined Treatment with Cat Allergen Immunotherapy and Tezepelumab on Nasal Allergen Challenge

2020 ◽  
Vol 145 (2) ◽  
pp. AB336 ◽  
Author(s):  
Jonathan Corren ◽  
Lisa Wheatley ◽  
Srinath Sanda ◽  
David Larson ◽  
Tielin Qin ◽  
...  
Keyword(s):  
Allergen Immunotherapy ◽  
Combined Treatment ◽  
Allergen Challenge ◽  
Cat Allergen ◽  
Nasal Allergen Challenge
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