In search of the golden ratio for cannabis allergy: utility of specific allergen‐to‐total IgE ratios

Introduction:Data visualization quality is important for the work of a geographic information system operator, determining the conditions under which he or she makes decisions concerning the displayed data. Visual perception patterns associated with the golden ratio properties allow us to formulate a criterion for data visualization quality which would characterize the possibilities of the operator’s complex perception of the video data displayed on a control device screen in the form of an electronic card.Purpose:Substantiation of a data visualization quality criterion for geoinformation systems using the golden ratio properties, and the study of the conditions for providing good visualization quality for geodata and metadata on a video control device screen in accordance with the proposed criterion.Methods:A formal definition of the data visualization quality criterion in geoinformation systems using the coefficient of the screen area information coverage as an index whose optimal value corresponds to the mathematical definition of the golden ratio; and the study of the properties of this criterion. Results: Based on the conducted analysis of visual perception of video data and golden ratio properties during the data visualization, a criterion is proposed for data visualization quality, which uses the golden ratio properties and characterizes the possibilities of complex perception of video data in an electronic map form by a geographic information system operator. Iteration algorithms for choosing the video data display scale are developed, based on the visualization quality criterion and related to the golden ratio properties. These are the basic algorithm used for each geodata layer represented on the electronicmap, and an algorithm of successive analysis of various layers of the displayed geodata. The choice of a video data display scale in accordance with the developed algorithms can be preliminarily carried out by the system operator using the parameters of standard electronic maps and geodata/metadata sets typical for the current applied problem. We have studied how the scale of the geodata and metadata displayed on an electronic map affects their visualization quality on screens of various sizes. For the considered standard volumes of displayed geodata and metadata, the best visualization quality was achieved when they were displayed on a standard computer monitor, as opposed to a portable notebook or visualization screen.Practical relevance:The proposed criterion and the recommendations for choosing a screen size for the video monitoring device or the structures of the displayed geo-objects and metadata can be used in the design of geoinformation systems, or for preliminary choice of the displayed data structure by a geoinformation system operator.

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Real-World Data Evaluation Of Total IgE, Specific IgE And Omalizumab Therapy In A Cohort Of Allergic Asthma Patients Treated In A Community-Based Practice

Journal of Immunology and Allergy ◽

10.37191/mapsci-2582-6549-1(3)-016 ◽

2020 ◽

Author(s):

Fortune O Alabi

Keyword(s):

Allergic Asthma ◽

Specific Ige ◽

Forced Expiratory Volume ◽

Act Scores ◽

Asthma Control Test ◽

Real World Data ◽

Total Ige ◽

Prick Test ◽

Negative Results ◽

Asthma Patients

Objective: In this study, we: (1) evaluated the correlation between total IgE and the presence of specific IgE; (2) compared the characteristics of patients with positive specific IgE to those with negative specific IgE; and, (3) analyzed the allergic testing results of patients on omalizumab and reported the effect of omalizumab on forced expiratory volume (FEV1) and asthma control test (ACT) results. Methods: Data from patients diagnosed with allergic asthma and seen at Florida Lung, Asthma & Sleep Specialists (FLASS) between January 2016 and June 2019 were analyzed. Parameters evaluated were total IgE, and levels of specific IgE to antigens in the ImmunoCAP test and skin prick test (SPT). Additional parameters for patients on omalizumab therapy for at least 6 months were FEV1, % predicted FEV1 and ACT results. Results: A total of 475 patients (114 males, 361 females) met the inclusion criteria. The mean age was 53 years (range: 17 to 89 years). Of these, 36 patients were not included in the analysis due to incomplete data. Mean total IgE was higher in patients with positive ImmunoCAP results compared to those with negative results (396 KU/L vs. 81.3 KU/L). There was a significant positive correlation between total IgE and levels of positive specific IgE in the ImmunoCAP test (p<0.0001, r=0.36, n=213 patients). The correlation between total IgE and levels of positive allergens in SPT was not significant (p=0.15, n=44 patients) Two positive reactions to allergens were seen in 22% of ImmunoCAP tests and 13% of SPT tests. There was no statistically significant improvement in FEV1 (p=0.097, CI -0.17 to 0.02) and % predicted FEV1 (p=0.109, CI -6.63 to 0.70) in patients who used omalizumab for at least 6 months. There was a statistically significant improvement in ACT scores (p=0.031, CI -4.21 to -0.21) in patients who used omalizumab for at least 6 months. Conclusion: Allergic asthma could be seen in patients who had an absence of specific IgE in ImmunoCAP and a negative reaction to SPT. The benefit of omalizumab therapy is not limited to allergic asthma patients with positive specific IgE.

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