Genetic variants in the TLR‐related pathway and smoking exposure alter the upper airway microbiota in adult asthmatic patients

Allergy ◽  
2021 ◽  
Author(s):  
Purevsuren Losol ◽  
Sae‐Hoon Kim ◽  
Soyeon Ahn ◽  
Sejoon Lee ◽  
Jun‐Pyo Choi ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Upper Airway ◽  
Asthmatic Patients ◽  
Smoking Exposure ◽  
Adult Asthmatic ◽  
Related Pathway

scholarly journals Genetic variants of SDCCAG8 and MAGI2 in mitosis‐related pathway genes are independent predictors of cutaneous melanoma‐specific survival

2021 ◽  
Author(s):  
Yuanmin He ◽  
Hongliang Liu ◽  
Sheng Luo ◽  
Christopher I. Amos ◽  
Jeffrey E. Lee ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Genetic Variants ◽  
Related Pathway

scholarly journals The effects of mold sensitivity on the clinical characteristics of adult asthmatic patients

2020 ◽  
Vol 88 (2) ◽  
pp. 99-107
Author(s):  
Dilek Karadoğan ◽  
Vehbi Ayhan ◽  
Adile Berna Dursun
Keyword(s):  
Clinical Characteristics ◽  
Asthmatic Patients ◽  
Adult Asthmatic

Sino-Nasal Characteristics in Asthmatic Patients

2012 ◽  
Vol 147 (5) ◽  
pp. 950-957 ◽  
Author(s):  
Wenche Moe Thorstensen ◽  
Vegard Bugten ◽  
Malcolm Sue-Chu ◽  
Nils Petter Wold Fossland ◽  
Pål Richard Romundstad ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Air Flow ◽  
Clinical Importance ◽  
Upper Airway ◽  
Upper Airways ◽  
Asthma Control Questionnaire ◽  
Tertiary Referral Center ◽  
Prick Test ◽  
Asthmatic Patients

Objective The Unified Airways Hypothesis suggests an involvement of the upper airways in asthma. We aimed to evaluate the association between subjective sino-nasal complaints, nasal air flow, and sino-nasal quality of life (QOL) in patients with asthma compared with nonasthmatic subjects. Study Design Case-control study. Setting A tertiary referral center. Subjects and Methods Symptoms, quality of life, and nasal airflow were assessed in 91 asthmatics and 95 nonasthmatic controls with Visual Analog Scale (VAS, 0-100), Sino-Nasal Outcome Test (SNOT-20), and Peak Nasal Inspiratory Flow (PNIF), respectively. Asthma and allergy status were assessed by Asthma Control Questionnaire (ACQ) and skin prick test or specific IgE. Results Asthmatic patients (men/women, 37/54; mean age, 43.7 years; range, 19-64 years) reported significantly more nasal obstruction (mean VAS, 37 mm; SD = 26, 95% CI, 32-43 vs 9 mm, SD = 11, 95% CI, 7-11, P < .001) and lower sino-nasal quality of life (mean SNOT-20, 1.3; SD = 0.8, 95% CI, 1.1-1.5 vs 0.4, SD = 0.5, 95% CI, 0.3-0.5, P < .001) than controls (men/women, 42/53; mean age, 43.8 years; range, 20-65 years). PNIF was significantly lower in asthmatic patients than controls (mean PNIF, 84 l/min; SD = 24, 95% CI, 79-89 vs 100 l/min SD = 24, 95% CI, 95-105, P < .001). Conclusion Both allergic and nonallergic asthma were associated with increased sino-nasal symptoms, reduced sino-nasal QOL, and reduced inspiratory nasal air flow compared to controls. This provides further evidence of the clinical importance of the upper airway in the diagnostic and therapeutic management of asthma patients beyond the scope of allergy.

A Meta-analysis of Intervention Studies on the Effects of Self Management and Education in Adult Asthmatic Patients

2015 ◽  
Vol 9 (3) ◽  
pp. 175-185
Author(s):  
Chae-Bong Kim ◽  
◽  
Min-Kyung Han ◽  
Mi-Seon Jeong ◽  
Bo-Young Choi ◽  
...  
Keyword(s):  
Intervention Studies ◽  
Meta Analysis ◽  
Self Management ◽  
Asthmatic Patients ◽  
Adult Asthmatic
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