High dimensional analysis defines multicytokine T‐cell subsets and supports a role for IL‐21 in atopic dermatitis

Allergy ◽  
2021 ◽  
Author(s):  
Tali Czarnowicki ◽  
Hyun Je Kim ◽  
Axel P Villani ◽  
Jacob Glickman ◽  
Ester Del Duca ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
Dimensional Analysis ◽  
T Cell Subsets ◽  
High Dimensional

Immunophenotyping of skin-infiltrating T-cell subsets in dogs with atopic dermatitis

1997 ◽  
Vol 57 (1-2) ◽  
pp. 13-23 ◽  
Author(s):  
Jacqueline D. Sinke ◽  
Theo Thepen ◽  
Ilse C. Bihari ◽  
Victor P.M.G. Rutten ◽  
Ton Willemse
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
T Cell Subsets

scholarly journals 074 Evolution of pathologic T-cell subsets in atopic dermatitis from infancy to adulthood

2019 ◽  
Vol 139 (5) ◽  
pp. S13
Author(s):  
T. Czarnowicki ◽  
H. He ◽  
H. Kim ◽  
N. Kameyama ◽  
J. Han ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
T Cell Subsets

Skin-homing and systemic T-cell subsets show higher activation in atopic dermatitis versus psoriasis

2015 ◽  
Vol 136 (1) ◽  
pp. 208-211 ◽  
Author(s):  
Tali Czarnowicki ◽  
Dana Malajian ◽  
Avner Shemer ◽  
Judilyn Fuentes-Duculan ◽  
Juana Gonzalez ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
T Cell Subsets ◽  
Skin Homing

Immune profiling of tumor-infiltrating T cells using mass cytometry.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 2607-2607
Author(s):  
David Roumanes ◽  
Evan Newell ◽  
Michael Fehlings
Keyword(s):  
T Cells ◽  
T Cell ◽  
Tumor Antigens ◽  
Human Cancer ◽  
Human Tumor ◽  
Tumor Infiltrating Lymphocytes ◽  
T Cell Subsets ◽  
High Dimensional ◽  
Tumor Bearing ◽  
Immune Profiling

2607 Background: Immunotherapy recent successes have opened new avenues for the treatment of cancer and the presence of tumor-specific CD8+ T cells in tumor-bearing individuals offer a promising therapeutic target. However, the detection and profiling of such T cells are challenging due to the need to detect rare antigen-specific T cell subpopulations in patient samples that are limited in size thus making it difficult to exploit these parameters for predictive signatures of clinical response. Moreover, the identification and analysis of neoantigen-specific CD8+ T-cells in tumor-bearing individuals is challenging due to the small pool of such cells. Methods: In order to identify therapy-relevant tumor antigens and to facilitate a concurrent in-depth characterization of cells directed towards these targets, immunoSCAPE leverages the high-dimensional immune profiling capabilities of cytometry by time of flight (CyTOF) combined with a unique technology allowing the identification rare antigen-specific T-cell subsets. Results: We applied this technology to patient tumor-infiltrating lymphocytes from human cancer samples and tumor-derived neoantigens recognized by T-cells were identified and characterized. Interestingly, the majority of patient-derived tumor infiltrates consisted of tumor-unrelated T-cells characterized by a diverse phenotype. Strikingly, the expression of CD39 was absent from these bystander cells, suggesting that CD39 could be a useful biomarker for the identification of putative tumor-reactive T cells. Conclusions: Simultaneous immune profiling revealed that tumor-unrelated, bystander CD8+ T-cells are phenotypically different in human tumor infiltrates and identified CD39 as a putative marker of neoantigen-specific T-cells. By providing insights into the nature, frequency and phenotype of antigen-specific T-cells, immunoSCAPE’s unique target discovery and high-dimensional immune profiling platform is a valuable tool for the development of novel diagnostic and therapeutic strategies in immunotherapy.

Changes in CD4+ T cell subsets (Th-1, Th-2) in skin lesions of patients with atopic dermatitis

1993 ◽  
Vol 6 (1) ◽  
pp. 67
Author(s):  
Takao Fujimura ◽  
Akira Fujioka ◽  
Yuko Hamada ◽  
Mikio Masuzawa ◽  
Shigeo Nishiyama
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
Skin Lesions ◽  
T Cell Subsets ◽  
Cd4 T Cell ◽  
Th 1

Analysis of Discrete Regulatory T Cell Subsets in Patients with Atopic Dermatitis Reveals Th2-Promoting Properties

2007 ◽  
Vol 119 (1) ◽  
pp. S238 ◽  
Author(s):  
A.J. Reefer ◽  
S.M. Satinover ◽  
J. Nguyen ◽  
M.D. Solga ◽  
J. Lannigan ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
Regulatory T Cell ◽  
T Cell Subsets

scholarly journals Evolution of pathologic T-cell subsets in patients with atopic dermatitis from infancy to adulthood

2020 ◽  
Vol 145 (1) ◽  
pp. 215-228 ◽  
Author(s):  
Tali Czarnowicki ◽  
Helen He ◽  
Talia Canter ◽  
Joseph Han ◽  
Rachel Lefferdink ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
T Cell Subsets
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