scholarly journals Successful oral desensitization and reintroduction in selected glioma patients with procarbazine‐mediated hypersensitivity

Allergy ◽  
2020 ◽  
Vol 75 (11) ◽  
pp. 2974-2976
Author(s):  
Hester Van der Valk ◽  
Hilda Dijkstra ◽  
Annemiek Walenkamp ◽  
Marie L.A. Schuttelaar ◽  
Hanneke N.G. Oude Elberink ◽  
...  
Keyword(s):  
Oral Desensitization

Oral desensitization in Rh disease

1983 ◽  
Vol 146 (8) ◽  
pp. 980-981 ◽  
Author(s):  
William R. Gold ◽  
John T. Queenan ◽  
James Woody ◽  
Ronald A. Sacher
Keyword(s):  
Oral Desensitization

scholarly journals Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Erika Yue Lee ◽  
Christine Song
Keyword(s):  
Hypersensitivity Reaction ◽  
Primary Biliary Cholangitis ◽  
Line Treatment ◽  
Second Line ◽  
Immediate Hypersensitivity ◽  
First Line ◽  
Case Presentation ◽  
Desensitization Protocol ◽  
First Line Treatment ◽  
Oral Desensitization

Abstract Background Immediate hypersensitivity reaction to ursodiol is rare and there is no previously published protocol on ursodiol desensitization. Case presentation A 59-year-old woman with primary biliary cholangitis (PBC) developed an immediate hypersensitivity reaction to ursodiol—the first-line treatment for PBC. When she switched to a second-line treatment, her PBC continued to progress. As such, she completed a novel 12-step desensitization protocol to oral ursodiol. She experienced recurrent pruritus after each dose following desensitization, which subsided after a month of being on daily ursodiol. Conclusion Immediate hypersensitivity reaction to ursodiol is uncommon. Our case demonstrated that this novel desensitization protocol to ursodiol could be safely implemented when alternative options are not available or have proven inferior in efficacy.

scholarly journals A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients

2013 ◽  
Vol 132 (6) ◽  
pp. 1368-1374 ◽  
Author(s):  
Lynda C. Schneider ◽  
Rima Rachid ◽  
Jennifer LeBovidge ◽  
Emily Blood ◽  
Mudita Mittal ◽  
...  
Keyword(s):  
Pilot Study ◽  
High Risk ◽  
Oral Desensitization

Anaphylaxis during rapid oral desensitization to rifampicin

2016 ◽  
Vol 4 (1) ◽  
pp. 173-174 ◽  
Author(s):  
Ekaterini Syrigou ◽  
Dimitra Grapsa ◽  
Eugenia Nanou ◽  
Maria Zande ◽  
Antonios Vassias ◽  
...  
Keyword(s):  
Oral Desensitization

Oral Desensitization in Papular Urticaria in Children

2002 ◽  
Vol 32 (3) ◽  
pp. 142-145 ◽  
Author(s):  
Susana Giraldi ◽  
Ramón Ruiz-Maldonado ◽  
Lourdes Tamayo ◽  
Cristina Sosa-de-Martínez
Keyword(s):  
Vaccine Efficacy ◽  
Oral Vaccine ◽  
Effective Means ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Before And After ◽  
Insect Bites ◽  
Oral Desensitization

Papular urticaria (PU) is among the commonest skin ailments in children. Induced specific desensitization to insect bites is theoretically an effective means of prevention of PU. In this double blind placebo controlled study, an oral vaccine prepared from insect saliva was compared with placebo (stable vaccine solvent). Vaccine and placebo effectiveness were tested by counting active PU lesions, serum eosinophils, and IgE, before and after 4 months of treatment. Statistically significant differences between oral vaccine and placebo were not found in the clinical or the immunological variables tested. We conclude that, although a lack of oral vaccine efficacy was suspected, larger study samples are needed to strengthen our conclusion.

Systemic Nickel Allergy: Oral Desensitization and Possible Role of Cytokines Interleukins 2 and 10

2013 ◽  
Vol 26 (1) ◽  
pp. 251-257 ◽  
Author(s):  
L. Ricciardi ◽  
A. Carnì ◽  
G. Loschiavo ◽  
S. Gangemi ◽  
V. Tigano ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Oral Tolerance ◽  
Challenge Test ◽  
Gastrointestinal Symptoms ◽  
Oral Immunotherapy ◽  
Nickel Allergy ◽  
Oral Challenge Test ◽  
Before And After ◽  
Desensitization Therapy ◽  
Oral Desensitization

Nickel ingested with food can elicit either systemic cutaneous or gastrointestinal symptoms causing a systemic nickel allergy syndrome (SNAS) that can be treated with tolerance by oral ingestion of the metal. It has been suggested that interleukins 2 (IL-2) and 10 (IL-10) are involved in the mechanisms underlying oral tolerance. We evaluated the clinical efficacy of oral desensitization therapy in SNAS consisting in the administration of nickel sulphate. Because nickel allergy prevalently affects women, only female subjects (N = 22) were recruited. Oral nickel desensitizing therapy was associated with low-nickel diet for three months. Before and after therapy, clinical conditions were evaluated, and circulating cytokines IL-2 and IL-10 were measured. After the two-year treatment, visual analogue scale (VAS) scores for symptoms were significantly reduced (P < 0.001). Patients were released by either cutaneous or gastrointestinal symptoms and by tolerating nickel-containing food. At the end of the treatment, nickel oral challenge test was negative in 18 patients, and IL-2 level in the serum was significantly reduced while IL-10 was increased, although this datum was not statistically significant. Our study confirms the clinical efficacy of nickel oral immunotherapy and focuses on the mechanisms triggered by oral tolerance indicating that reduction of IL-2 can be associated with success of oral nickel desensitizing therapy.

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