scholarly journals Stability of regulatory T cells in T helper 2–biased allergic airway diseases

Allergy ◽  
2020 ◽  
Vol 75 (8) ◽  
pp. 1918-1926 ◽  
Author(s):  
Feng Lan ◽  
Nan Zhang ◽  
Claus Bachert ◽  
Luo Zhang
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
T Helper ◽  
T Helper 2 ◽  
Airway Diseases

scholarly journals FOXP3+ Regulatory T Cells and T Helper 1, T Helper 2, and T Helper 17 Cells in Human Early Pregnancy Decidua1

2010 ◽  
Vol 82 (4) ◽  
pp. 698-705 ◽  
Author(s):  
Jenny Mjösberg ◽  
Göran Berg ◽  
Maria C. Jenmalm ◽  
Jan Ernerudh
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Early Pregnancy ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 17 ◽  
T Helper 17 Cells ◽  
T Helper 2

scholarly journals Polypoidal Choroidal Vasculopathy Associate With Diminished Regulatory T Cells That Are Polarized Into a T Helper 2-Like Phenotype

2019 ◽  
Vol 60 (7) ◽  
pp. 2583 ◽  
Author(s):  
Yousif Subhi ◽  
Marie Krogh Nielsen ◽  
Christopher Rue Molbech ◽  
Akio Oishi ◽  
Amardeep Singh ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Polypoidal Choroidal Vasculopathy ◽  
T Helper ◽  
T Helper 2 ◽  
Choroidal Vasculopathy

scholarly journals Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells

2007 ◽  
Vol 204 (2) ◽  
pp. 357-367 ◽  
Author(s):  
Hamida Hammad ◽  
Mirjam Kool ◽  
Thomas Soullié ◽  
Shuh Narumiya ◽  
François Trottein ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Airway Inflammation ◽  
Cell Function ◽  
Interleukin 10 ◽  
Prostaglandin D2 ◽  
T Helper ◽  
T Helper 2 ◽  
Novel Treatments ◽  
Dependent Protein

Prostaglandins (PGs) can enhance or suppress inflammation by acting on different receptors expressed by hematopoietic and nonhematopoietic cells. Prostaglandin D2 binds to the D prostanoid (DP)1 and DP2 receptor and is seen as a critical mediator of asthma causing vasodilation, bronchoconstriction, and inflammatory cell influx. Here we show that inhalation of a selective DP1 agonist suppresses the cardinal features of asthma by targeting the function of lung dendritic cells (DCs). In mice treated with DP1 agonist or receiving DP1 agonist-treated DCs, there was an increase in Foxp3+ CD4+ regulatory T cells that suppressed inflammation in an interleukin 10–dependent way. These effects of DP1 agonist on DCs were mediated by cyclic AMP–dependent protein kinase A. We furthermore show that activation of DP1 by an endogenous ligand inhibits airway inflammation as chimeric mice with selective hematopoietic loss of DP1 had strongly enhanced airway inflammation and antigen-pulsed DCs lacking DP1 were better at inducing airway T helper 2 responses in the lung. Triggering DP1 on DCs is an important mechanism to induce regulatory T cells and to control the extent of airway inflammation. This pathway could be exploited to design novel treatments for asthma.

Tregs in fibrosis: To know your enemy, you must become your enemy

2019 ◽  
Vol 4 (39) ◽  
pp. eaay1160 ◽  
Author(s):  
Suzanne M. Bal ◽  
Ralph Stadhouders
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Cytokine Production ◽  
T Helper ◽  
Related Research ◽  
T Helper 2 ◽  
Link Type ◽  
Research Article

T helper 2–skewed regulatory T cells in the skin use GATA3 to suppress local profibrotic type 2 cytokine production. See the related Research Article by Kalekar et al.

scholarly journals CD4+FoxP3+regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection

2014 ◽  
Vol 44 (12) ◽  
pp. 3596-3604 ◽  
Author(s):  
Bianca Schulze ◽  
Daniel Piehler ◽  
Maria Eschke ◽  
Heiner von Buttlar ◽  
Gabriele Köhler ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Fungal Infection ◽  
T Helper ◽  
T Helper 2 ◽  
Cell Immunity

scholarly journals A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells

Immunity ◽  
2019 ◽  
Vol 50 (2) ◽  
pp. 362-377.e6 ◽  
Author(s):  
Frédéric Van Gool ◽  
Michelle L.T. Nguyen ◽  
Maxwell R. Mumbach ◽  
Ansuman T. Satpathy ◽  
Wendy L. Rosenthal ◽  
...  
Keyword(s):  
T Cells ◽  
Transcription Factor ◽  
Regulatory T Cells ◽  
Effector Function ◽  
T Helper ◽  
T Helper 2

Differential role T helper 1, T helper 2 and CD4+CD25+ regulatory T cells in the development of collateral vessels following induced acute ischemia

Cytokine ◽  
2009 ◽  
Vol 48 (1-2) ◽  
pp. 118
Author(s):  
Laura Pontecorvo ◽  
Eugenio Stabile ◽  
Leopoldo Laricchia-Robbio ◽  
Giuseppe Rosano ◽  
Andrea la Sala
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Acute Ischemia ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2 ◽  
Collateral Vessels
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