scholarly journals IL‐1β prevents ILC2 expansion, type 2 cytokine secretion, and mucus metaplasia in response to early‐life rhinovirus infection in mice

Allergy ◽  
2020 ◽  
Vol 75 (8) ◽  
pp. 2005-2019 ◽  
Author(s):  
Mingyuan Han ◽  
Tomoko Ishikawa ◽  
Jennifer R. Bermick ◽  
Charu Rajput ◽  
Jing Lei ◽  
...  
Keyword(s):  
Early Life ◽  
Cytokine Secretion ◽  
Rhinovirus Infection ◽  
Mucus Metaplasia

Early-life exposure to the Chinese famine, genetic susceptibility and the risk of type 2 diabetes in adulthood

Diabetologia ◽  
2021 ◽  
Author(s):  
Bin Wang ◽  
Jing Cheng ◽  
Heng Wan ◽  
Yuying Wang ◽  
Wen Zhang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Susceptibility ◽  
Early Life ◽  
Early Life Exposure

scholarly journals The effect of mid-life insulin resistance and type 2 diabetes on older-age cognitive state: the explanatory role of early-life advantage

Diabetologia ◽  
2019 ◽  
Vol 62 (10) ◽  
pp. 1891-1900
Author(s):  
Sarah-Naomi James ◽  
Andrew Wong ◽  
Therese Tillin ◽  
Rebecca Hardy ◽  
Nishi Chaturvedi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Early Life ◽  
Older Age ◽  
Cognitive State ◽  
Explanatory Role

scholarly journals The association of early life socioeconomic conditions with prediabetes and type 2 diabetes: results from the Maastricht study

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Ivonne P. M. Derks ◽  
Annemarie Koster ◽  
Miranda T. Schram ◽  
Coen D. A. Stehouwer ◽  
Pieter C. Dagnelie ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Life ◽  
Socioeconomic Conditions

scholarly journals T2DM: Why Epigenetics?

2011 ◽  
Vol 2011 ◽  
pp. 1-17 ◽  
Author(s):  
Delphine Fradin ◽  
Pierre Bougnères
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Environmental Factors ◽  
Early Life ◽  
Time Dependent ◽  
Phenotypic Traits ◽  
To Come ◽  
Genetic And Environmental Factors

Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder influenced by interactions between genetic and environmental factors. Epigenetics conveys specific environmental influences into phenotypic traits through a variety of mechanisms that are often installed in early life, then persist in differentiated tissues with the power to modulate the expression of many genes, although undergoing time-dependent alterations. There is still no evidence that epigenetics contributes significantly to the causes or transmission of T2DM from one generation to another, thus, to the current environment-driven epidemics, but it has become so likely, as pointed out in this paper, that one can expect an efflorescence of epigenetic knowledge about T2DM in times to come.

scholarly journals Associations between early-life food deprivation during World War II and risk of hypertension and type 2 diabetes at adulthood

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Julia Mink ◽  
Marie-Christine Boutron-Ruault ◽  
Marie-Aline Charles ◽  
Olivier Allais ◽  
Guy Fagherazzi
Keyword(s):  
Type 2 Diabetes ◽  
World War Ii ◽  
Food Deprivation ◽  
Early Life ◽  
World War
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