scholarly journals Pollen season is reflected on symptom load for grass and birch pollen‐induced allergic rhinitis in different geographic areas—An EAACI Task Force Report

Allergy ◽  
2020 ◽  
Vol 75 (5) ◽  
pp. 1099-1106 ◽  
Author(s):  
Oliver Pfaar ◽  
Kostas Karatzas ◽  
Katharina Bastl ◽  
Uwe Berger ◽  
Jeroen Buters ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Pollen Season ◽  
Task Force ◽  
Birch Pollen ◽  
Task Force Report ◽  
Symptom Load

New European Academy of Allergy and Clinical Immunology definition on pollen season mirrors symptom load for grass and birch pollen-induced allergic rhinitis

Allergy ◽  
2018 ◽  
Vol 73 (9) ◽  
pp. 1851-1859 ◽  
Author(s):  
K. Karatzas ◽  
N. Katsifarakis ◽  
M. Riga ◽  
B. Werchan ◽  
M. Werchan ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Immunology ◽  
Pollen Season ◽  
Birch Pollen ◽  
European Academy ◽  
Symptom Load

scholarly journals Specific probiotics alleviate allergic rhinitis during the birch pollen season

2009 ◽  
Vol 15 (26) ◽  
pp. 3261 ◽  
Author(s):  
Arthur C Ouwehand ◽  
Merja Nermes ◽  
Maria Carmen Collado ◽  
Nina Rautonen ◽  
Seppo Salminen ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Pollen Season ◽  
Birch Pollen

scholarly journals Histology-Based Blood Leukocyte Profiling Reveals Parallel Th2 and Th17 Signatures in Seasonal Allergic Rhinitis

2020 ◽  
Author(s):  
Premkumar Siddhuraj ◽  
Franziska U Nordström ◽  
Prajakta Jogdand ◽  
Gayathri Elongovan ◽  
Michiko Mori ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Pollen Season ◽  
Immune Cell ◽  
Ex Vivo ◽  
Birch Pollen ◽  
Allergic Inflammation ◽  
Immune Alterations ◽  
Positive Method ◽  
Blood Leukocyte ◽  
Feasibility Test

Abstract Background : Allergic rhinitis (AR) is one of the most common medical conditions in the westernized world. Recent data suggest AR to be far more immunologically complex than the archetypical allergic Th2-driven eosinophilic inflammation and new methodological approaches are needed to decode this complexity. Methods : This study explores a novel histology-based analysis of circulating leukocytes for detailed profiling of immune cells using routine clinical blood samples. In brief, leukocytes were purified with minimal ex-vivo artefacts, embedded into agarose-paraffin pellets and sectioned for cutting-edge immunohistochemistry-based immune cell profiling. Blood leukocyte mapping was performed in 16 patients with seasonal AR outside and during the birch pollen season. Results : Our methodological feasibility test confirmed that the > 5000 cross sectioned leukocytes typically present in a pellet section had well preserved morphology and cell marker epitopes, allowing for robust quantitative analysis of immune-stained slides. Blood leukocyte samples collected during the allergen season had statistically higher levels of markers for eosinophils, neutrophils, monocytes and CD8 lymphocytes compared to the off-season baseline. No change was observed for CD20 B-lymphocytes, total CD3 T cells and basophils. Subclassification of CD4+ T-helper cells demonstrated a parallel and significant expansion of Th2 and Th17 cells during the pollen season, while Th1 cells remained unchanged. Whereas absolute basophils numbers were unaltered, a significant increase of the basophil markers GATA2 and CPA3 was observed during the pollen season. Conclusions: Apart from representing a positive method feasibility validation, our study provides further evidence of complex and parallel Th2 and Th17 immune signatures in seasonal AR. Our data also forward GATA2 and basophil CPA3 as potential biomarkers for ongoing allergic inflammation. It is thus proposed that the present histology-based approach, with its broad applicability, represents a powerful tool for decoding systemic immune alterations and guide novel biomarker strategies for improved personalized medication.

Characteristic of pollen seasons in the most sensitizing plants based on 15 years of observation in Warsaw

2018 ◽  
Vol 72 (5) ◽  
pp. 1-5
Author(s):  
Agnieszka Lipiec ◽  
Piotr Rapiejko ◽  
Konrad Furmańczyk ◽  
Dariusz Jurkiewicz
Keyword(s):  
Allergic Rhinitis ◽  
Grass Pollen ◽  
Maximum Concentration ◽  
Pollen Season ◽  
Birch Pollen ◽  
Threshold Concentration ◽  
Polish Population ◽  
Pollen Concentrations ◽  
Pollen Seasons ◽  
Daily Concentration

Introduction Allergic rhinitis concerns nearly 25% of the Polish population. Among pollen allergens, the most common reasons for allergic rhinitis are: grass, birch and mugwort. Knowledge of the characteristics of pollen seasons is necessary in diagnostics, monitoring of therapy and prevention of allergic rhinitis. Purpose This work aims to analyze the pollen seasons of the most commonly sensitizing plants in the Polish population; grass, birch and mugwort in the years 2003-2017 in Warsaw. Material and methods Measurements of pollen concentration were carried out using the Burkard volumetric apparatus operating in continuous volumetric mode. The analysis of pollen seasons was conducted based on the following characteristics: beginning, end, and length of season, annual sum of daily pollen concentrations, maximum daily concentration, number of days with maximum and threshold concentration. Linear regression together with the Pearson correlation coefficient were used in statistical analysis to study the relationship between variables; furthermore, descriptive characteristics of distributions studied were determined. Results The average date of the beginning of the birch pollen season in the analyzed period is April 10th, and it belongs to seasons of average length (47 days on average). Concentration above 75z/m3, when most allergic people expect allergic symptoms, was recorded for an average of 18 days. The highest daily concentration of birch pollen reaching 6321 grains/m3 (2006, 2012, 2016) exceeded the lowest value of the maximum concentration by almost 20 times (2015). Among the taxa analyzed, the highest values of daily concentration and annual sums were recorded for birch pollen. The average date for the beginning of grass pollination season is on May 13th. It is the longest pollen season (on average 134 days), and the period when concentration exceeded 50z/m3 covered an average of 26 days. The highest daily concentration of grass pollen reaching 496 grains/m3 (2005 and 2007) exceeded the lowest value of maximum concentration by 3.5 times (2016). The average date of the beginning of the brackish pollen season is July 16th. The season lasts 65 days on average, when concentration exceeding 30z/m3 was registered for an average of 12 days. The highest daily concentration of mugwort pollen reaching 154 grains/m3 (2007) exceeded the lowest value of maximum concentration by 4 times (2013). For all analyzed taxa, the strongest correlated variables are the annual sum of daily pollen concentrations (Seasonal Pollen Index) and daily maximum concentration (correlation for birch pollen = 0.92, for grass pollen = 0.88, and for mugwort pollen = 0.91) Conclusions Periods of pollen in the air show certain variation in the analyzed 15-year period. The maximum concentration in the pollen season for the analyzed taxa and the annual sum of daily concentrations of pollen show the highest variability, particularly strongly expressed in the case of birch pollen. There is a linear relationship between the annual sum of daily pollen concentrations and the maximum concentration value as well as the number of days with the threshold concentration for all analyzed taxa. Variability of parameters describing the dynamics of pollen seasons indicates the need to monitor, both by patients with hay fever and physicians, the current information about the concentration of pollen in the air during the pollen season.

scholarly journals Clinical efficacy of subcutaneous and sublingual allergen-specific immunotherapy of allergic rhinitis and conjunctivitis

2016 ◽  
Vol 13 (6) ◽  
pp. 63-69
Author(s):  
I E Kozulina ◽  
K S Pavlova ◽  
O M Kurbacheva
Keyword(s):  
Allergic Rhinitis ◽  
Pollen Season ◽  
Specific Immunotherapy ◽  
Pharmacoeconomic Analysis ◽  
Birch Pollen ◽  
Cost Utility ◽  
Efficacy And Safety ◽  
Allergen Specific Immunotherapy ◽  
Cost Efficacy ◽  
The Cost

Objective. To evaluate the efficacy and safety of subcutaneous and sublingual allergen-specific immunotherapy (AIT), a comparative pharmaco-economic analysis. Materials and methods. The study included 60 patients with allergic rhinitis and conjunctivitis with or without asthma induced by birch pollen. In the first group patients received subcutaneous AIT (SCIT) by «Phostal - allergen of trees pollen», in the second group - sublingual AIT (SLIT) by «Staloral - allergen of birch pollen». Results. All patients after the SCIT or SLIT in the first pollen season noted a decrease in the severity of nasal and conjunctival symptoms (SMD -1,93 [95% CI -2,39; -1,47] and -1,57 [95% CI -2,39; -0,75] for groups 1 and 2, respectively) and a decrease in the rescue medication requirement (SMD -1,98 [95% CI -2,57; -1,39] and -1,86 [95% CI -2,61; -1,11] for groups 1 and 2, respectively). There were no statistically significant differences between the SCIT and SLIT efficacy. After AIT in both groups there was a significant reduction in the cost of medication and medical services (on average 5 times). In a comparative pharmacoeconomic analysis «cost/efficacy» and «cost/utility» was showed comparable results of SCIT and SLIT.

Allergy to oak pollen in North America

2021 ◽  
Vol 42 (1) ◽  
pp. 43-54 ◽  
Author(s):  
David I. Bernstein ◽  
Peter A. Würtzen ◽  
Lawrence DuBuske ◽  
Michael S. Blaiss ◽  
Anne K. Ellis ◽  
...  
Keyword(s):  
United States ◽  
Allergic Rhinitis ◽  
North America ◽  
Pollen Season ◽  
Birch Pollen ◽  
The United States ◽  
Cross Reactivity ◽  
Pollen Allergens ◽  
Homologous Group ◽  
Oak Pollen

Background: Oak pollen is an important allergen in North America. The genus Quercus (oak) belongs to the family Fagaceae under the order Fagales. Objective: The objective of this article was to narratively review the oak pollen season, clinical and epidemiologic aspects of allergy to oak pollen, oak taxonomy, and oak allergen cross-reactivity, with a focus on the North American perspective. Methods: A PubMed literature review (no limits) was conducted. Publications related to oak pollen, oak-related allergic rhinitis with or without conjunctivitis, and oak-related allergic asthma were selected for review. Results: Oak species are common throughout the United States and contribute up to 50% to overall atmospheric pollen loads. Mean peak oak pollen counts can reach >2000 grains/m3. The start of the oak pollen season generally corresponds to the seasonal shift from winter to spring based on latitude and elevation, and may begin as early as mid February. The duration of the season can last > 100 days and, in general, is longer at lower latitudes. In the United States, ∼30% of individuals with allergy are sensitized to oak. The oak pollen season correlates with increased allergic rhinitis symptom‐relieving medication use and asthma-related emergency department visits or hospitalizations. Oak falls within the birch homologous group. Extensive immunologic cross-reactivity has been demonstrated between oak pollen and birch pollen allergens, and, more specifically, their major allergens Que a 1 and Bet v 1. The cross-reactivity between oak and birch has implications for allergy immunotherapy (AIT) because guidelines suggest selecting one representative allergen within a homologous group for AIT, a principle that would apply to oak. Conclusion: Allergy to oak pollen is common in North America and has a substantial clinical impact. Oak pollen allergens are cross-reactive with birch pollen allergens, which may have implications for AIT.

scholarly journals The development of birch pollen seasons over 30 years in Munich, Germany—An EAACI Task Force report*

Allergy ◽  
2020 ◽  
Vol 75 (12) ◽  
pp. 3024-3026 ◽  
Author(s):  
Karl‐Christian Bergmann ◽  
Jeroen Buters ◽  
Kostas Karatzas ◽  
Thomas Tasioulis ◽  
Barbora Werchan ◽  
...  
Keyword(s):  
Task Force ◽  
Birch Pollen ◽  
Task Force Report ◽  
Pollen Seasons
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