Eosinophil extracellular traps activate type 2 innate lymphoid cells through stimulating airway epithelium in severe asthma

Allergy ◽  
2019 ◽  
Vol 75 (1) ◽  
pp. 95-103 ◽  
Author(s):  
Youngwoo Choi ◽  
Young‐Min Kim ◽  
Hee‐Ra Lee ◽  
Jiyeong Mun ◽  
Soyoon Sim ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Airway Epithelium ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Extracellular Traps

scholarly journals Mesenchymal Stem Cells Suppress Severe Asthma by Directly Regulating Th2 Cells and Type 2 Innate Lymphoid Cells

2021 ◽  
Vol 44 (8) ◽  
pp. 580-590
Author(s):  
Jae Woo Shin ◽  
Seungwon Ryu ◽  
Jongho Ham ◽  
Keehoon Jung ◽  
Sangho Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Severe Asthma ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Th2 Cells

scholarly journals Type 2 innate lymphoid cells in induced sputum from children with severe asthma

2016 ◽  
Vol 137 (2) ◽  
pp. 624-626.e6 ◽  
Author(s):  
Prasad Nagakumar ◽  
Laura Denney ◽  
Louise Fleming ◽  
Andrew Bush ◽  
Clare M. Lloyd ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Induced Sputum

scholarly journals Group 2 innate lymphoid cells (ILC2s): The spotlight in asthma pathogenesis and lung tissue injury

2021 ◽  
Vol 49 (2) ◽  
pp. 208-216
Author(s):  
Sunusi Sadik ◽  
Yanhong Lu ◽  
Shaoxuan Zhu ◽  
Jiayu Cai ◽  
Lan Lan Mi
Keyword(s):  
Lung Tissue ◽  
Airway Epithelium ◽  
Structural Changes ◽  
Clinical Symptoms ◽  
Tissue Injury ◽  
Airflow Obstruction ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 2

Asthma is a heterogeneous disease with ranging etiology and severity. Asthma is a disease of chronic inflammation of the airways, with clinical symptoms of wheezing, breathlessness, cough, and chest tightness manifested as chronic fixed or variable airflow obstruction and airway hyperresponsiveness that predispose the airway epithelium to repeated injury, repair, and regeneration. In recent years, innate lymphoid cells (ILC1, ILC2, and ILC3) have been discovered. The predominant ILC type found in the lung tissue is group 2 innate lymphoid cells (ILC2s). Upon damage to the airway epithelium mediating the release of epithelial cytokines (TSLP, IL-33, and IL-25) ensued the activation of ILC2 in an antigen-independent manner. Activated ILC2 produces a significant amount of type 2 cytokines (IL-4, IL-5, IL-9, and IL-13), altogether contributing to type 2 inflammation in the airways. ILC2s are mediators of type 2 immunity for many type 2 inflammatory diseases such as asthma, since ILC2s were reported to play an important role in asthma pathogenesis. Here we discuss the role of ILC2 in the development of asthma and ILC2 effector cytokines (IL-4, IL-5, and IL-13) contributing to airway epithelial structural changes.

A pro-inflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
K Karimi ◽  
K Neumann ◽  
J Meiners ◽  
R Voetlause ◽  
W Dammermann ◽  
...  
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Immune Mediated

1886-P: Hepatic Type 2 Innate Lymphoid Cells Suppress Gluconeogenesis via the IL-33/GATA3/IL-13 Axis

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1886-P
Author(s):  
MASANORI FUJIMOTO ◽  
KOUTARO YOKOTE ◽  
TOMOAKI TANAKA
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells
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