scholarly journals Lipid Transfer Protein allergy in the United Kingdom: Characterization and comparison with a matched Italian cohort

Allergy ◽  
2019 ◽  
Vol 74 (7) ◽  
pp. 1340-1351 ◽  
Author(s):  
Isabel J. Skypala ◽  
Lorenzo Cecchi ◽  
Mohamed H. Shamji ◽  
Enrico Scala ◽  
Stephen Till
Keyword(s):  
United Kingdom ◽  
Lipid Transfer Protein ◽  
Lipid Transfer ◽  
Transfer Protein ◽  
The United Kingdom ◽  
Italian Cohort

Non-specific lipid transfer protein allergy in United Kingdom

2019 ◽  
Vol 123 (6) ◽  
pp. 618-620
Author(s):  
Ariharan Anantharachagan ◽  
Roweida Sammour ◽  
Pavaladurai Vijayadurai
Keyword(s):  
United Kingdom ◽  
Lipid Transfer Protein ◽  
Lipid Transfer ◽  
Transfer Protein ◽  
Specific Lipid

Lipid transfer protein sensitization: reactivity profiles and clinical risk assessment in an Italian cohort

Allergy ◽  
2015 ◽  
Vol 70 (8) ◽  
pp. 933-943 ◽  
Author(s):  
E. Scala ◽  
S. J. Till ◽  
R. Asero ◽  
D. Abeni ◽  
E. C. Guerra ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Lipid Transfer Protein ◽  
Lipid Transfer ◽  
Transfer Protein ◽  
Clinical Risk ◽  
Clinical Risk Assessment ◽  
Protein Sensitization ◽  
Italian Cohort

scholarly journals The key to the allergenicity of lipid transfer protein (LTP) ligands: A structural characterization

2021 ◽  
pp. 158928
Author(s):  
Zulema Gonzalez-Klein ◽  
Bruno Cuevas-Zuviria ◽  
Andrea Wangorsch ◽  
Guadalupe Hernandez-Ramirez ◽  
Diego Pazos-Castro ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Lipid Transfer Protein ◽  
Lipid Transfer ◽  
Transfer Protein

scholarly journals Structural Characterization of Act c 10.0101 and Pun g 1.0101—Allergens from the Non-Specific Lipid Transfer Protein Family

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 256
Author(s):  
Andrea O’Malley ◽  
Swanandi Pote ◽  
Ivana Giangrieco ◽  
Lisa Tuppo ◽  
Anna Gawlicka-Chruszcz ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Lipid Transfer Protein ◽  
Mass Spectrometry Analysis ◽  
Lipid Transfer ◽  
Helical Structures ◽  
Spectrometry Analysis ◽  
X Ray Crystallography ◽  
Transfer Protein ◽  
Specific Lipid

(1) Background: Non-specific lipid transfer proteins (nsLTPs), which belong to the prolamin superfamily, are potent allergens. While the biological role of LTPs is still not well understood, it is known that these proteins bind lipids. Allergen nsLTPs are characterized by significant stability and resistance to digestion. (2) Methods: nsLTPs from gold kiwifruit (Act c 10.0101) and pomegranate (Pun g 1.0101) were isolated from their natural sources and structurally characterized using X-ray crystallography (3) Results: Both proteins crystallized and their crystal structures were determined. The proteins have a very similar overall fold with characteristic compact, mainly α-helical structures. The C-terminal sequence of Act c 10.0101 was updated based on our structural and mass spectrometry analysis. Information on proteins’ sequences and structures was used to estimate the risk of cross-reactive reactions between Act c 10.0101 or Pun g 1.0101 and other allergens from this family of proteins. (4) Conclusions: Structural studies indicate a conformational flexibility of allergens from the nsLTP family and suggest that immunoglobulin E binding to some surface regions of these allergens may depend on ligand binding. Both Act c 10.0101 and Pun g 1.0101 are likely to be involved in cross-reactive reactions involving other proteins from the nsLTP family.

Structural Stability and Surface Activity of Sunflower 2S Albumins and Nonspecific Lipid Transfer Protein

2010 ◽  
Vol 58 (10) ◽  
pp. 6490-6497 ◽  
Author(s):  
Bernadett Berecz ◽  
E. N. Clare Mills ◽  
László Tamás ◽  
Ferenc Láng ◽  
Peter R. Shewry ◽  
...  
Keyword(s):  
Structural Stability ◽  
Surface Activity ◽  
Lipid Transfer Protein ◽  
Lipid Transfer ◽  
Transfer Protein ◽  
2S Albumins ◽  
Nonspecific Lipid Transfer Protein
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