Enhanced therapeutic effects of human mesenchymal stem cells transduced with superoxide dismutase 3 in a murine atopic dermatitis-like skin inflammation model

Allergy ◽  
2018 ◽  
Vol 73 (12) ◽  
pp. 2364-2376 ◽  
Author(s):  
Shyam Kishor Sah ◽  
Gaurav Agrahari ◽  
Cuong Thach Nguyen ◽  
Yeon-Soo Kim ◽  
Kyung-Sun Kang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Superoxide Dismutase ◽  
Mesenchymal Stem Cells ◽  
Atopic Dermatitis ◽  
Human Mesenchymal Stem Cells ◽  
Skin Inflammation ◽  
Therapeutic Effects ◽  
Inflammation Model ◽  
Superoxide Dismutase 3

scholarly journals Therapeutic Effects of Human Mesenchymal Stem Cells inEx VivoHuman Lungs Injured with Live Bacteria

2013 ◽  
Vol 187 (7) ◽  
pp. 751-760 ◽  
Author(s):  
Jae W. Lee ◽  
Anna Krasnodembskaya ◽  
David H. McKenna ◽  
Yuanlin Song ◽  
Jason Abbott ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Therapeutic Effects ◽  
Live Bacteria

scholarly journals Therapeutic Benefits by Human Mesenchymal Stem Cells (hMSCs) and Ang-1 Gene-Modified hMSCs after Cerebral Ischemia

2007 ◽  
Vol 28 (2) ◽  
pp. 329-340 ◽  
Author(s):  
Toshiyuki Onda ◽  
Osamu Honmou ◽  
Kuniaki Harada ◽  
Kiyohiro Houkin ◽  
Hirofumi Hamada ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cerebral Artery ◽  
Human Mesenchymal Stem Cells ◽  
Artery Occlusion ◽  
Control Group ◽  
Therapeutic Effects ◽  
Lesion Volume ◽  
Therapeutic Benefits ◽  
Cerebral Artery Occlusion

Transplantation of human mesenchymal stem cells (hMSCs) prepared from adult bone marrow has been reported to ameliorate functional deficits after cerebral artery occlusion in rats. Although several hypotheses to account for these therapeutic effects have been suggested, current thinking is that both neuroprotection and angiogenesis are primarily responsible. In this study, we compared the effects of hMSCs and angiopoietin-1 gene-modified hMSCs (Ang-hMSCs) intravenously infused into rats 6 h after permanent middle cerebral artery occlusion. Magnetic resonance imaging and histologic analyses revealed that rats receiving hMSCs or Ang-hMSCs exhibited comparable reduction in gross lesion volume as compared with the control group. Although both cell types indeed improved angiogenesis near the border of the ischemic lesions, neovascularization and regional cerebral blood flow were greater in some border areas in Ang-hMSC group. Both hMSC- and Ang-hMSC-treated rats showed greater improved functional recovery in the treadmill stress test than did control rats, but the Ang-hMSC group was greater. These results indicate the intravenous administration of genetically modified hMSCs to express angiopoietin has a similar effect on reducing lesion volume as hMSCs, but the Ang-hMSC group showed enhanced regions of increased angiogenesis at the lesion border, and modest additional improvement in functional outcome.

Superoxide dismutase 3 facilitates the chondrogenesis of bone marrow-derived mesenchymal stem cells

2019 ◽  
Vol 509 (4) ◽  
pp. 983-987 ◽  
Author(s):  
Yuanyuan Shi ◽  
Xiaoqing Hu ◽  
Xin Zhang ◽  
Jin Cheng ◽  
Xiaoning Duan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Superoxide Dismutase ◽  
Mesenchymal Stem Cells ◽  
Superoxide Dismutase 3

scholarly journals The DLC-1 tumor suppressor is involved in regulating immunomodulation of human mesenchymal stem cells through interacting with the Notch1 protein

2019 ◽  
Author(s):  
Tao Na ◽  
Kehua Zhang ◽  
Bao-Zhu Yuan
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Suppressor ◽  
Mutual Exclusion ◽  
Human Mesenchymal Stem Cells ◽  
Fine Tuning ◽  
Therapeutic Effects ◽  
Critical Function ◽  
E3 Ligases ◽  
Notch1 Signaling

Abstract Immunomodulatory activities of human mesenchymal stem cells (hMSCs) have been widely accepted as the most critical function of the cells for exerting its therapeutic effects. The activities include the inhibition by hMSCs on pro-inflammatory CD4 + -T lymphocytes, and the release of immunomodulatory molecules, like IDO1. However, the detailed mechanisms responsible for regulating the immunomodulation of hMSCs still remain largely unknown. Previously, the Notch1 protein has been demonstrated to be able to promote the immunomodulation of hMSCs through inhibiting CD4 + -Th1 lymphocyte proliferation and enhancing IDO1 expression. The present study further revealed that it was the Notch1-Hey1 axis, rather than the Notch1-Hes1 axis, that was likely responsible for mediating the immunomodulation of the Notch1 signaling. Meanwhile, following a previously proposed hypothesis to identify proteasome-regulated protein(s) for limiting the activity of the Notch1 signaling in hMSCS, the DLC-1 tumor suppressor was identified to be such a candidate protein, which was subjected to protein degradation mediated by the DDB1 and FBXW5 E3 ligases . It was further shown that the DLC-1 signaling composing of DLC-1, Rock1 and FBXW5 proteins was involved in inhibiting the immunomodulation of hMSCs. More importantly, the immunomodulation was achieved through an interaction between the DLC-1-FBXW5-Rock1 signaling and the Notch1-Hey1 signaling . In fact, the present study a novel function of DLC-1 tumor suppressor as well as proposed a new mutual exclusion mechanism likely responsible for fine-tuning the immunomodulation of hMSCs.

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