scholarly journals The IL-13/periostin/IL-24 pathway causes epidermal barrier dysfunction in allergic skin inflammation

Allergy ◽  
2018 ◽  
Vol 73 (9) ◽  
pp. 1881-1891 ◽  
Author(s):  
Y. Mitamura ◽  
S. Nunomura ◽  
Y. Nanri ◽  
M. Ogawa ◽  
T. Yoshihara ◽  
...  
Keyword(s):  
Skin Inflammation ◽  
Barrier Dysfunction ◽  
Epidermal Barrier ◽  
Allergic Skin

scholarly journals Experience of modern skin care series Atopic® using in atopic dermatitis children

2017 ◽  
Vol 14 (2) ◽  
pp. 76-81
Author(s):  
O G Elisyutina ◽  
A O Litovkina ◽  
E S Fedenko
Keyword(s):  
Immune Response ◽  
Atopic Dermatitis ◽  
Inflammatory Disease ◽  
Skin Care ◽  
Barrier Dysfunction ◽  
Epidermal Barrier ◽  
Endogenous Factors ◽  
Complex Therapy ◽  
Allergic Skin ◽  
Disease Stages

Atopic dermatitis - chronic allergic skin inflammatory disease with genetic predisposition, dysbalance of immune response, dysfunction of an epidermal barrier and influence of various exogenous and endogenous factors. Epidermal barrier dysfunction leads to rising of permeability of a skin for allergens, microbs and nonspecific stimuli, as well as to sensitivity to various external influences. Clinically these implications are shown by skin xerosis symptoms therefore. According to modern clinical guidelines, the moisturizing agents, so called emollients, have to be used at all disease stages. Own data on use of modern skin care series Atopic® in complex therapy of atopic dermatitis patients are presented in the article.

scholarly journals Mast Cells Regulate Epidermal Barrier Function and the Development of Allergic Skin Inflammation

2016 ◽  
Vol 136 (7) ◽  
pp. 1429-1437 ◽  
Author(s):  
Sarita Sehra ◽  
Ana P.M. Serezani ◽  
Jesus A. Ocaña ◽  
Jeffrey B. Travers ◽  
Mark H. Kaplan
Keyword(s):  
Mast Cells ◽  
Barrier Function ◽  
Skin Inflammation ◽  
Epidermal Barrier ◽  
Allergic Skin

scholarly journals Atopic dermatitis: experimentalmodels for study of pathogenesis and development of new methods of treatment

2011 ◽  
Vol 8 (6) ◽  
pp. 3-11
Author(s):  
N N Shershakova ◽  
A A Babakhin ◽  
O G Elisyutina ◽  
M R Khaitov ◽  
N N Shershakova ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Barrier ◽  
Skin Inflammation ◽  
Barrier Dysfunction ◽  
Skin Injury ◽  
Allergic Skin ◽  
Promising Area ◽  
Functional Peptides ◽  
Methods Of Treatment

Atopic dermatitis (AD) is characterized by allergic skin inflammation. A hallmark of AD is dry itchy skin due, at least in part, to defects in skin genes that are important for maintaining barrier function. The pathogenesis of AD remains incompletely understood. A number of mouse models of AD have been developed. This review discusses these models and emphasizes the role of mechanical skin injury and skin barrier dysfunction in eliciting allergic skin inflammation. Also, we describe various approaches to the treatment of atopic dermatitis, the latest of which is the introduction of siRN A. Development of drugs based on siRN A using functional peptides is a promising area of research in allergology.

scholarly journals The efficacy and safety of local therapy of atopic dermatitis in infants and school-age children

2020 ◽  
pp. 54-59
Author(s):  
O. I. Sidorovich ◽  
A. A. Tsyvkina ◽  
G. D. Abdullaeva
Keyword(s):  
Atopic Dermatitis ◽  
Local Therapy ◽  
Calcineurin Inhibitors ◽  
Skin Inflammation ◽  
School Age Children ◽  
Skin Barrier Function ◽  
Barrier Dysfunction ◽  
Epidermal Barrier ◽  
Atopic March ◽  
Age Related

Atopic dermatitis is a multifactorial genetic inflammatory skin disease associated with disturbances of skin barrier function affected by predisposition to IgE-mediated hypersensitivity, which is characterized by itching, chronic recurrent course of the disease, age-related features of localization and lesion morphology, and requires the long-term and permanent treatment.Treatment is based on the continuous use of emollients, topical calcineurin inhibitors, topical glucocorticoids, and hygienic skin care.The mechanisms of the atopic dermatitis development are primarily based on a genetic predisposition to allergies, failure of the normal development of congenital and acquired factors of the immune system, as well as the influence of environmental factors and various trigger factors, such as allergenic (food, indoor, epidermal, fungal allergens, etc.). and non-allergenic (tobacco smoke, pollutants, psycho-emotional stress, concomitant chronic and acute diseases, mainly ARVI, etc.).It has been established that atopic dermatitis is characterized by the epidermal barrier dysfunction leading to excessive tran-sepidermal water loss, increased permeability of the epidermis, the penetration of allergens and microbial agents via the skin and eventually to sensitization to allergens and the development of specific allergic skin inflammation and atopic march with the sequential development of other atopic diseases.Modern therapeutic strategies are actively aimed at repairing the epidermal barrier, preventing sensitization and atopic march development. This article describes the features of the epidermal barrier dysfunction in atopic dermatitis, lists the methods of its restoration and ways to prevent subsequent exacerbations using local therapy and emollients, and presents 3 clinical cases.

The Impact of Ultraviolet Radiation on Barrier Function in Human Skin: Molecular Mechanisms and Topical Therapeutics

2019 ◽  
Vol 25 (40) ◽  
pp. 5503-5511 ◽  
Author(s):  
Abdulaziz Alhasaniah ◽  
Michael J. Sherratt ◽  
Catherine A. O'Neill
Keyword(s):  
Ultraviolet Radiation ◽  
Barrier Function ◽  
Molecular Mechanisms ◽  
Transepidermal Water Loss ◽  
Protective Effects ◽  
Barrier Dysfunction ◽  
Epidermal Barrier ◽  
Positive Effects ◽  
Terrestrial Mammals ◽  
The Impact

A competent epidermal barrier is crucial for terrestrial mammals. This barrier must keep in water and prevent entry of noxious stimuli. Most importantly, the epidermis must also be a barrier to ultraviolet radiation (UVR) from the sunlight. Currently, the effects of ultraviolet radiation on epidermal barrier function are poorly understood. However, studies in mice and more limited work in humans suggest that the epidermal barrier becomes more permeable, as measured by increased transepidermal water loss, in response UVR, at doses sufficiently high to induce erythema. The mechanisms may include disturbance in the organisation of lipids in the stratum corneum (the outermost layer of the epidermis) and reduction in tight junction function in the granular layer (the first living layer of the skin). By contrast, suberythemal doses of UVR appear to have positive effects on epidermal barrier function. Topical sunscreens have direct and indirect protective effects on the barrier through their ability to block UV and also due to their moisturising or occlusive effects, which trap water in the skin, respectively. Some topical agents such as specific botanical extracts have been shown to prevent the loss of water associated with high doses of UVR. In this review, we discuss the current literature and suggest that the biology of UVR-induced barrier dysfunction, and the use of topical products to protect the barrier, are areas worthy of further investigation.

Central, but not peripheral, nervous system ERK2 is essential for itch signals in murine allergic skin inflammation

Allergy ◽  
2021 ◽  
Author(s):  
Shinsuke Matsuo ◽  
Takashi Hashimoto ◽  
Fumhiro Matsuura ◽  
Osamu Imamura ◽  
Shogo Endo ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Skin Inflammation ◽  
Allergic Skin

scholarly journals Eosinophils Mediate Basophil-Dependent Allergic Skin Inflammation in Mice

2019 ◽  
Vol 139 (9) ◽  
pp. 1957-1965.e2 ◽  
Author(s):  
Joerg U. Eberle ◽  
Daniel Radtke ◽  
Falk Nimmerjahn ◽  
David Voehringer
Keyword(s):  
Skin Inflammation ◽  
Allergic Skin

scholarly journals CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation

2002 ◽  
Vol 109 (5) ◽  
pp. 621-628 ◽  
Author(s):  
Weilie Ma ◽  
Paul J. Bryce ◽  
Alison A. Humbles ◽  
Dhafer Laouini ◽  
Ali Yalcindag ◽  
...  
Keyword(s):  
Murine Model ◽  
Airway Hyperresponsiveness ◽  
Skin Inflammation ◽  
Allergic Skin
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