scholarly journals Beyond epithelial-to-mesenchymal transition: Common suppression of differentiation programs underlies epithelial barrier dysfunction in mild, moderate, and severe asthma

Allergy ◽  
2017 ◽  
Vol 72 (12) ◽  
pp. 1988-2004 ◽  
Author(s):  
L. F. Loffredo ◽  
H. Abdala-Valencia ◽  
K. R. Anekalla ◽  
L. Cuervo-Pardo ◽  
C. J. Gottardi ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Epithelial To Mesenchymal Transition ◽  
Epithelial Barrier ◽  
Barrier Dysfunction ◽  
Mesenchymal Transition ◽  
Epithelial Barrier Dysfunction

scholarly journals Ma Xing Shi Gan Decoction Protects against PM2.5-Induced Lung Injury through Suppression of Epithelial-to-Mesenchymal Transition (EMT) and Epithelial Barrier Disruption

2020 ◽  
Vol 2020 ◽  
pp. 1-17
Author(s):  
Ye-fang Wang ◽  
Yu-xiang Fei ◽  
Bo Zhao ◽  
Qi-yang Yin ◽  
Jian-ping Zhu ◽  
...  
Keyword(s):  
Lung Injury ◽  
Epithelial To Mesenchymal Transition ◽  
Cell Model ◽  
Alveolar Epithelial Cell ◽  
Epithelial Barrier ◽  
Barrier Dysfunction ◽  
Mesenchymal Transition ◽  
Epithelial Barrier Dysfunction

This research was designed to explore the effect of Ma Xing Shi Gan decoction (MXD) in alleviating particulate matter less than 2.5 μm in diameter (PM2.5) induced lung injury from the perspective of epithelial barrier protection and inhibition of epithelial-to-mesenchymal transition (EMT). Rats were exposed to PM2.5 to establish a lung injury model in vivo, and a PM2.5-stimulated primary cultured type II alveolar epithelial cell model was introduced in vitro. Our results indicated that MXD alleviated the weight loss and pathologic changes and improved the epithelial barrier dysfunction. MXD also significantly inhibited the TGF-β/Smad3 pathway, increased the level of ZO-1 and claudin-5, and reversed the EMT process. Notably, the protection of MXD was abolished by TGF-β in vitro. Our results indicated that MXD has a protection against PM2.5-induced lung injury. The proposed mechanism is reversing PM2.5-induced EMT through inhibiting TGF-β/Smad3 pathway and then upregulating the expression of tight-junction proteins.

NAD+ Ameliorates Inflammation-Induced Epithelial Barrier Dysfunction in Cultured Enterocytes and Mouse Ileal Mucosa

2003 ◽  
Vol 307 (2) ◽  
pp. 443-449 ◽  
Author(s):  
Xiaonan Han ◽  
Takashi Uchiyama ◽  
Penny L. Sappington ◽  
Arino Yaguchi ◽  
Runkuan Yang ◽  
...  
Keyword(s):  
Epithelial Barrier ◽  
Barrier Dysfunction ◽  
Ileal Mucosa ◽  
Epithelial Barrier Dysfunction

scholarly journals Intestinal Epithelial Barrier Dysfunction in Food Hypersensitivity

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Linda Chia-Hui Yu
Keyword(s):  
Mast Cell ◽  
Cell Surface ◽  
Critical Role ◽  
Mast Cell Activation ◽  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Barrier Dysfunction ◽  
Intestinal Epithelial Barrier ◽  
Food Antigens ◽  
Epithelial Barrier Dysfunction

Intestinal epithelial barrier plays a critical role in the maintenance of gut homeostasis by limiting the penetration of luminal bacteria and dietary allergens, yet allowing antigen sampling for the generation of tolerance. Undigested proteins normally do not gain access to the lamina propria due to physical exclusion by tight junctions at the cell-cell contact sites and intracellular degradation by lysosomal enzymes in enterocytes. An intriguing question then arises: how do macromolecular food antigens cross the epithelial barrier? This review discusses the epithelial barrier dysfunction in sensitized intestine with special emphasis on the molecular mechanism of the enhanced transcytotic rates of allergens. The sensitization phase of allergy is characterized by antigen-induced cross-linking of IgE bound to high affinity FcεRI on mast cell surface, leading to anaphylactic responses. Recent studies have demonstrated that prior to mast cell activation, food allergens are transported in large quantity across the epithelium and are protected from lysosomal degradation by binding to cell surface IgE and low-affinity receptor CD23/FcεRII. Improved immunotherapies are currently under study including anti-IgE and anti-CD23 antibodies for the management of atopic disorders.

Correlation between cyclical epithelial barrier dysfunction and bacterial translocation in the relapses of intestinal inflammation

2006 ◽  
Vol 12 (9) ◽  
pp. 843-852 ◽  
Author(s):  
Monica Porras ◽  
Maria Teresa Martín ◽  
Ping-Chang Yang ◽  
Jennifer Jury ◽  
Mary H. Perdue ◽  
...  
Keyword(s):  
Bacterial Translocation ◽  
Intestinal Inflammation ◽  
Epithelial Barrier ◽  
Barrier Dysfunction ◽  
Epithelial Barrier Dysfunction

scholarly journals Homocysteine Aggravates Intestinal Epithelial Barrier Dysfunction in Rats with Experimental Uremia

2018 ◽  
Vol 43 (5) ◽  
pp. 1516-1528 ◽  
Author(s):  
Shanshan Liang ◽  
Sixiu Liu ◽  
Hua Liu ◽  
Xin He ◽  
Lingshuang Sun ◽  
...  
Keyword(s):  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Barrier Dysfunction ◽  
Intestinal Epithelial Barrier ◽  
Epithelial Barrier Dysfunction

scholarly journals Treponema denticola Induces Epithelial Barrier Dysfunction in Polarized Epithelial Cells

2018 ◽  
Vol 59 (4) ◽  
pp. 265-275 ◽  
Author(s):  
Yuichiro Kikuchi ◽  
Ryuta Kimizuka ◽  
Tetsuo Kato ◽  
Katsuji Okuda ◽  
Eitoyo Kokubu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Epithelial Barrier ◽  
Treponema Denticola ◽  
Barrier Dysfunction ◽  
Polarized Epithelial Cells ◽  
Epithelial Barrier Dysfunction
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