Optimal step doses for drug provocation tests to prove beta-lactam hypersensitivity

Allergy ◽  
2016 ◽  
Vol 72 (4) ◽  
pp. 552-561 ◽  
Author(s):  
A.-M. Chiriac ◽  
T. Rerkpattanapipat ◽  
P.-J. Bousquet ◽  
N. Molinari ◽  
P. Demoly
Keyword(s):  
Beta Lactam ◽  
Provocation Tests ◽  
Drug Provocation Tests

scholarly journals Beta-Lactam Allergy: Real Practice in a Regional Hospital

2021 ◽  
Vol 96 (1) ◽  
pp. 42-47
Author(s):  
Hyerim Kim ◽  
Jaechun Lee ◽  
Sejin Kim
Keyword(s):  
Emergency Room ◽  
Drug Administration ◽  
Bacterial Infections ◽  
Skin Tests ◽  
Beta Lactam ◽  
Provocation Tests ◽  
Inflammatory Drugs ◽  
Real Practice ◽  
Symptoms And Signs ◽  
Drug Provocation Tests

Background/Aims: Beta-lactam (BL) antibiotics are widely prescribed for controlling bacterial infections and relevant culprits of adverse drug reactions (ADRs). BL allergy may vary according to prescription patterns within a given period of time. However, BL allergy in contemporary clinical practice has rarely been a focus of research.Methods: To investigate the clinical characteristics of BL allergy, subjects with ADRs to medicines, including BL antibiotics, were retrospectively reviewed.Results: Among the 175 enrolled subjects, BL antibiotics as culprits were confirmed in 79 (45.1%, female 53.2%, age 49 ± 14 years). Among the patients with confirmed BL allergy, only two (2.5%) were diagnosed via a prescription survey completed as part of multi-drug administration. The others were confirmed by serologic tests in 33 patients (41.8%), skin tests in 29 (36.7%), and drug provocation tests in 15 (19.0%). Regarding the symptoms and signs, onset within an hour of taking medicines was common (61 patients, 77.3%). Itchy skin was most common, followed by hives, rash, breathing difficulty, angioedema, and hypotension. Anaphylaxis occurred in 67%, and one-half (50.6%) of patients visited the emergency room. Cefaclor and amoxicillin were common BL culprits. Among others who did not have BL allergy, nonsteroidal anti-inflammatory drugs were found to be common culprits, followed by quinolones.Conclusions: BL allergy is common among patients who experienced ADRs to medicines including BL antibiotics. For multi-drug administration, a prescription survey hardly helped in confirming BL allergy. Anaphylaxis is common in patients with BL allergy, frequently leading to emergency room visits. Cefaclor and amoxicillin are common culprits.

Systemic reaction during intradermal skin tests with beta-lactams

2021 ◽  
Vol 14 (3) ◽  
pp. e240050
Author(s):  
Joana Carvalho ◽  
Georgeta Oliveira
Keyword(s):  
Skin Testing ◽  
Drug Hypersensitivity ◽  
Systemic Reaction ◽  
Skin Tests ◽  
Beta Lactam ◽  
Provocation Tests ◽  
Maculopapular Eruption ◽  
Intradermal Tests ◽  
Amoxicillin Clavulanate ◽  
Immediate Reactions

Beta-lactam (BL) antibiotics are the most frequent cause of drug hypersensitivity in children, inducing both immediate and non-immediate reactions. Here we report a case of a 4-year-old child with a disseminated maculopapular exanthema 7 days after the first dose of amoxicillin–clavulanate, referred to our paediatric allergy department. Skin prick tests were negative. Intradermal tests were performed and, after 10 hours, indurated wheals larger than 10×10 mm with progressive erythema and disseminated maculopapular eruption were developed, related to amoxicillin and amoxicillin–clavulanate. Systemic reactions to BL skin tests are rarely reported and the majority are immediate reactions. This case illustrates a rare example of a non-immediate systemic reaction to intradermal tests, underlying the importance of skin testing before drug provocation tests in cases of moderate to severe non-immediate reactions.

scholarly journals Skin and in vitro tests reduce the need for drug provocation tests in drug hypersensitivity to betalactams

2020 ◽  
Author(s):  
Stefan W hrl ◽  
Christian Ostermayer ◽  
Gabriele Sesztak Greinecker ◽  
Reinhart Jarisch ◽  
Wolfgang Hemmer ◽  
...  
Keyword(s):  
Drug Hypersensitivity ◽  
In Vitro Tests ◽  
Provocation Tests ◽  
Drug Provocation Tests

scholarly journals Post exposition to etoricoxib in patients with negative oral drug provocation tests

2015 ◽  
Vol 8 ◽  
pp. A186 ◽  
Author(s):  
Thais Sterza ◽  
Pedro HR Fernandes ◽  
Cristiane Momoi ◽  
Luis Felipe Ensina ◽  
Inês Cristina Camelo Nunes ◽  
...  
Keyword(s):  
Oral Drug ◽  
Provocation Tests ◽  
Drug Provocation Tests
Sign in / Sign up

Export Citation Format

Share Document