scholarly journals Effect of grass pollen immunotherapy on clinical and local immune response to nasal allergen challenge

Allergy ◽  
2015 ◽  
Vol 70 (6) ◽  
pp. 689-696 ◽  
Author(s):  
G. W. Scadding ◽  
A. O. Eifan ◽  
M. Lao‐Araya ◽  
M. Penagos ◽  
S. Y. Poon ◽  
...  
Keyword(s):  
Immune Response ◽  
Grass Pollen ◽  
Allergen Challenge ◽  
Local Immune Response ◽  
Nasal Allergen Challenge

Effector cell signature in peripheral blood following nasal allergen challenge in grass pollen allergic individuals

Allergy ◽  
2015 ◽  
Vol 70 (2) ◽  
pp. 171-179 ◽  
Author(s):  
M. H. Shamji ◽  
V. Bellido ◽  
G. W. Scadding ◽  
J. A. Layhadi ◽  
D. K. M. Cheung ◽  
...  
Keyword(s):  
Grass Pollen ◽  
Peripheral Blood ◽  
Effector Cell ◽  
Allergen Challenge ◽  
Nasal Allergen Challenge

Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes

2012 ◽  
Vol 384 (1-2) ◽  
pp. 25-32 ◽  
Author(s):  
Guy W. Scadding ◽  
Moises A. Calderon ◽  
Virginia Bellido ◽  
Gitte Konsgaard Koed ◽  
Niels-Christian Nielsen ◽  
...  
Keyword(s):  
Grass Pollen ◽  
Allergen Challenge ◽  
Nasal Allergen Challenge

The Effect of Vitamin D Supplementation on Mucosal IL-5, MMP9 and Cathelicidin after Nasal Allergen Challenge with Grass Pollen

2016 ◽  
Vol 137 (2) ◽  
pp. AB73 ◽  
Author(s):  
Natasha C. Gunawardana ◽  
Gaynor Campbell ◽  
Sarah Lindsley ◽  
Elizabeth E. Mann ◽  
Peter J.M. Openshaw ◽  
...  
Keyword(s):  
Vitamin D ◽  
Grass Pollen ◽  
Allergen Challenge ◽  
Vitamin D Supplementation ◽  
Nasal Allergen Challenge

Unilateral nasal allergen challenge leads to bilateral release of prostaglandin D2

1996 ◽  
Vol 26 (4) ◽  
pp. 371-378 ◽  
Author(s):  
M. WAGENMANN ◽  
F. M. BAROODY ◽  
M. DESROSIERS ◽  
W. C. HUBBARD ◽  
S. FORD ◽  
...  
Keyword(s):  
Allergen Challenge ◽  
Prostaglandin D2 ◽  
Nasal Allergen Challenge

scholarly journals Local Immune Response in Skin of Generalized Vitiligo Patients

2000 ◽  
Vol 80 (8) ◽  
pp. 1299-1309 ◽  
Author(s):  
René van den Wijngaard ◽  
Anna Wankowicz-Kalinska ◽  
Caroline Le Poole ◽  
Bert Tigges ◽  
Wiete Westerhof ◽  
...  
Keyword(s):  
Immune Response ◽  
Local Immune Response

Development of nasal allergen challenge with cockroach in children with asthma

2021 ◽  
Author(s):  
Amanda K. Rudman Spergel ◽  
Michelle L. Sever ◽  
Jacqueline Johnson ◽  
Michelle A. Gill ◽  
Veronique Schulten ◽  
...  
Keyword(s):  
Allergen Challenge ◽  
Children With Asthma ◽  
Nasal Allergen Challenge

PS02.176: LINE-1 METHYLATION LEVEL AND LOCAL IMMUNE RESPONSE IN ESOPHAGEAL CANCER

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 172-172
Author(s):  
Yoshifumi Baba ◽  
Taisuke Yagi ◽  
Yuki Kiyozumi ◽  
Yukiharu Hiyoshi ◽  
Masaaki Iwatsuki ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Immune Response ◽  
Esophageal Cancer ◽  
Methylation Level ◽  
Cpg Island ◽  
Surrogate Marker ◽  
Esophageal Tumor ◽  
Local Immune Response ◽  
Dna Hypomethylation ◽  
Response Status

Abstract Background In cancer cells, DNA methylation may be altered in two principle ways; global DNA hypomethylation and site-specific CpG island promoter hypermethylation. Since Long interspersed element-1 (LINE-1 or L1; a repetitive DNA retrotransposon) constitutes a substantial portion (approximately 17%) of the human genome, the extent of LINE-1 methylation is regarded as a surrogate marker of global DNA methylation. In previous studies, we demonstrated that LINE-1 hypomethylation was strongly associated with a poor prognosis in esophageal cancer, supporting its potential role as a prognostic marker (Ann Surg 2012). We also found that LINE-1-hypomethylated tumors showed highly frequent genomic gains at various loci containing candidate oncogenes such as CDK6 (Clin Cancer Res 2014). Given that immunotherapy, as represented by PD-1/PD-L1-targeting antibodies, has increasingly gained attention as a novel treatment strategy for esophageal cancer, better understanding of local immune response status in esophageal cancer is important. The aim of this study is to evaluate the relationship between LINE-1 methylation level and local immune response in esophageal cancer. Methods Using a non-biased database of 305 curatively resected esophageal cancers, we evaluated PD-L1 expression and TIL status (CD8 expression) by immunohistochemical analysis (Ann Surg 2017). Results TIL positivity was significantly correlated with longer overall survival (log-rank P < 0.0001). TIL-negative cases demonstrated significantly lower LINE-1 methylation level compared with TIL-positive cases (P = 0.012). This finding certainly supports that LINE-1 methylation level may influence the local immune response status. Conclusion PD-L1 expression was not related with LINE-1 methylation level. Further investigations in this field would provide deeper insights into esophageal tumor immunology and assist the development of new therapeutic strategies against esophageal cancer. Disclosure All authors have declared no conflicts of interest.

Interaction of epithelial biomarkers, local immune response and condom use in cervical intraepithelial neoplasia 2–3 regression

2012 ◽  
Vol 127 (3) ◽  
pp. 489-494 ◽  
Author(s):  
Ane Cecilie Munk ◽  
Einar Gudlaugsson ◽  
Irene Tveiteras Ovestad ◽  
Kjell Lovslett ◽  
Bent Fiane ◽  
...  
Keyword(s):  
Immune Response ◽  
Condom Use ◽  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
Local Immune Response

scholarly journals The local immune response in ulcerative lesions of Buruli disease

2006 ◽  
Vol 143 (3) ◽  
pp. 445-451 ◽  
Author(s):  
A. E. Kiszewski ◽  
E. Becerril ◽  
L. D. Aguilar ◽  
I. T. A. Kader ◽  
W. Myers ◽  
...  
Keyword(s):  
Immune Response ◽  
Local Immune Response ◽  
Ulcerative Lesions
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