Sputum and BAL Clara cell secretory protein and surfactant protein D levels in asthma

Allergy ◽  
2015 ◽  
Vol 70 (6) ◽  
pp. 711-714 ◽  
Author(s):  
P. Emmanouil ◽  
S. Loukides ◽  
K. Kostikas ◽  
G. Papatheodorou ◽  
A. Papaporfyriou ◽  
...  
Keyword(s):  
Surfactant Protein ◽  
Secretory Protein ◽  
Clara Cell ◽  
Surfactant Protein D ◽  
Clara Cell Secretory Protein

Clara Cell Secretory Protein and Surfactant Protein-D Do Not Predict Bronchiolitis Obliterans Syndrome After Lung Transplantation

2010 ◽  
Vol 90 (3) ◽  
pp. 340-342 ◽  
Author(s):  
Annelieke W. M. Paantjens ◽  
Henny G. Otten ◽  
Walter G. J. van Ginkel ◽  
Diana A. van Kessel ◽  
Jules M. M. van den Bosch ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Bronchiolitis Obliterans ◽  
Surfactant Protein ◽  
Secretory Protein ◽  
Bronchiolitis Obliterans Syndrome ◽  
Clara Cell ◽  
Surfactant Protein D ◽  
Clara Cell Secretory Protein

Clara Cell Secretory Protein (CC16) And Surfactant Protein D In Sputum Supernatant In Severe Refractory Asthma

2012 ◽  
Author(s):  
Philip Emmanouil ◽  
Stylianos Loukides ◽  
Konstantinos Kostikas ◽  
Anastasia Papaporfyriou ◽  
George Hillas ◽  
...  
Keyword(s):  
Surfactant Protein ◽  
Secretory Protein ◽  
Clara Cell ◽  
Surfactant Protein D ◽  
Clara Cell Secretory Protein ◽  
Refractory Asthma

Iroquoisgenes influence proximo-distal morphogenesis during rat lung development

2006 ◽  
Vol 290 (4) ◽  
pp. L777-L789 ◽  
Author(s):  
Minke van Tuyl ◽  
Jason Liu ◽  
Freek Groenman ◽  
Ross Ridsdale ◽  
Robin N. N. Han ◽  
...  
Keyword(s):  
Lung Development ◽  
Cell Formation ◽  
Surfactant Protein ◽  
Branching Morphogenesis ◽  
Secretory Protein ◽  
Clara Cell ◽  
Fgf Receptor ◽  
Clara Cell Secretory Protein ◽  
Morphogenetic Protein

Lung development is a highly regulated process directed by mesenchymal-epithelial interactions, which coordinate the temporal and spatial expression of multiple regulatory factors required for proper lung formation. The Iroquois homeobox ( Irx) genes have been implicated in the patterning and specification of several Drosophila and vertebrate organs, including the heart. Herein, we investigated whether the Irx genes play a role in lung morphogenesis. We found that Irx1– 3 and Irx5 expression was confined to the branching lung epithelium, whereas Irx4 was not expressed in the developing lung. Antisense knockdown of all pulmonary Irx genes together dramatically decreased distal branching morphogenesis and increased distention of the proximal tubules in vitro, which was accompanied by a reduction in surfactant protein C-positive epithelial cells and an increase in β-tubulin IV and Clara cell secretory protein positive epithelial structures. Transmission electron microscopy confirmed the proximal phenotype of the epithelial structures. Furthermore, antisense Irx knockdown resulted in loss of lung mesenchyme and abnormal smooth muscle cell formation. Expression of fibroblast growth factors (FGF) 1, 7, and 10, FGF receptor 2, bone morphogenetic protein 4, and Sonic hedgehog (Shh) were not altered in lung explants treated with antisense Irx oligonucleotides. All four Irx genes were expressed in Shh- and Gli2-deficient murine lungs. Collectively, these results suggest that Irx genes are involved in the regulation of proximo-distal morphogenesis of the developing lung but are likely not linked to the FGF, BMP, or Shh signaling pathways.

Structure and Regulation of the Murine Clara Cell Secretory Protein Gene

Genomics ◽  
1994 ◽  
Vol 20 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Barry R. Stripp ◽  
Jacquelyn A. Huffman ◽  
Robert J. Bohinski
Keyword(s):  
Protein Gene ◽  
Secretory Protein ◽  
Clara Cell ◽  
Clara Cell Secretory Protein

The Expression of Clara Cell Secretory Protein in BAL Fluid of Patients with Idiopathic Interstitial Pneumonia

2002 ◽  
Vol 53 (2) ◽  
pp. 127
Author(s):  
Sang Won Um ◽  
Seon Jin Han ◽  
Chang Min Choi ◽  
Chang Hoon Lee ◽  
Chul Gyu Yoo ◽  
...  
Keyword(s):  
Interstitial Pneumonia ◽  
Secretory Protein ◽  
Idiopathic Interstitial Pneumonia ◽  
Clara Cell ◽  
Clara Cell Secretory Protein
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