A tryptophan metabolite, kynurenine, promotes mast cell activation through aryl hydrocarbon receptor

Allergy ◽  
2014 ◽  
Vol 69 (4) ◽  
pp. 445-452 ◽  
Author(s):  
H. Kawasaki ◽  
H.-W. Chang ◽  
H.-C. Tseng ◽  
S.-C. Hsu ◽  
S.-J. Yang ◽  
...  
Keyword(s):  
Mast Cell ◽  
Aryl Hydrocarbon Receptor ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Aryl Hydrocarbon ◽  
Tryptophan Metabolite

scholarly journals Aryl hydrocarbon receptor controls murine mast cell homeostasis

Blood ◽  
2013 ◽  
Vol 121 (16) ◽  
pp. 3195-3204 ◽  
Author(s):  
Yufeng Zhou ◽  
Hui-Ying Tung ◽  
Ying-Ming Tsai ◽  
Shih-Chang Hsu ◽  
Hui-Wen Chang ◽  
...  
Keyword(s):  
Mast Cell ◽  
Aryl Hydrocarbon Receptor ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Cell Homeostasis ◽  
Aryl Hydrocarbon ◽  
Key Points ◽  
Murine Mast Cell

Key Points AhR ligands result in calcium- and ROS-dependent enhancement of mast cell activation. AhR is critical in controlling mast cell homeostasis.

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