scholarly journals A phase 1 study of heat/phenol-killed,E. coli-encapsulated, recombinant modified peanut proteins Ara h 1, Ara h 2, and Ara h 3 (EMP-123) for the treatment of peanut allergy

Allergy ◽  
2013 ◽  
Vol 68 (6) ◽  
pp. 803-808 ◽  
Author(s):  
R. A. Wood ◽  
S. H. Sicherer ◽  
A. W. Burks ◽  
A. Grishin ◽  
A. K. Henning ◽  
...  
Keyword(s):  
Peanut Allergy ◽  
Phase 1 ◽  
Phase 1 Study ◽  
Ara H 2 ◽  
E Coli ◽  
Ara H 1 ◽  
Ara H 3 ◽  
Peanut Proteins

scholarly journals Sensitization and Allergic Response and Intervention Therapy in Animal Models

2004 ◽  
Vol 87 (6) ◽  
pp. 1441-1447 ◽  
Author(s):  
Ricki M Helm ◽  
A Wesley Burks
Keyword(s):  
Animal Models ◽  
Allergic Sensitization ◽  
Food Allergies ◽  
Swine Model ◽  
Murine Models ◽  
Tobacco Plants ◽  
E Coli ◽  
Ige Binding ◽  
Ara H 1 ◽  
Peanut Proteins

Abstract A review is presented of 3 murine models and a swine neonatal model used to investigate immunotherapeutic options. In Model 1, mutation of linear IgE-binding epitopes of Ara h 1 for the preparation of a hypoallergenic Ara h 1 is discussed with respect to expression in transgenic tobacco plants and correct folding following expression in the pET16b construct. In Model 2, the mutations of Ara h 1 were assessed for use as an immunotherapeutic agent. Although some protective benefit was observed with the modified Ara h 1 protein, animals desensitized with heat-killed E. coli preparations showed increased protection to challenge. In Model 3, soybean homologs to peanut proteins were investigated to determine if soybean immunotherapy can potentially provide benefit to peanut-allergic subjects. Although some protection was provided, additional experimentation with respect to optimal doses for sensitization and challenge will need to be investigated. In Model 4, the neonatal swine model was used to profile different foods (low to moderate to high sensitizing) similar to food allergies in humans. Evidence suggests such feasiblity; however, threshold levels for sensitization and allergic responses will need additional study. In summary, murine and swine animal models are being used to address immunotherapeutic avenues and investigation into the mechanisms of food-allergic sensitization.

The Majority of the Effector Activity of a Crude Peanut Extract Co-purifies with Ara h 2 but not Ara h 1 or Ara h 3

2007 ◽  
Vol 119 (1) ◽  
pp. S193 ◽  
Author(s):  
H.S. Porterfield ◽  
M.W. Duncan ◽  
K.C. Hansen ◽  
S.C. Dreskin
Keyword(s):  
Ara H 2 ◽  
Ara H 1 ◽  
Ara H 3 ◽  
Peanut Extract ◽  
Effector Activity

scholarly journals Standardization of RP-HPLC methods for the detection of the major peanut allergens Ara h 1, Ara h 2 and Ara h 3

2016 ◽  
Vol 194 ◽  
pp. 383-390 ◽  
Author(s):  
Harmit Singh ◽  
Mary Jo Cantoria ◽  
Poonam Malave ◽  
Denny Saputra ◽  
Soheila Maleki
Keyword(s):  
Ara H 2 ◽  
Rp Hplc ◽  
Ara H 1 ◽  
Ara H 3 ◽  
Peanut Allergens

scholarly journals Comparison of major peanut allergens Ara h 1, Ara h 2 and Ara h 3 between peanut cultivars from Côte d’Ivoire and the USA using SDS PAGE and Western Blots

2017 ◽  
Vol 12 (01) ◽  
pp. 31-36
Author(s):  
Chiayé Claire Antoinette Yapo-Crezoit ◽  
Antony Ananga ◽  
Francis Yapo ◽  
Koffi Konan ◽  
Hortense Dodo
Keyword(s):  
Cote D'ivoire ◽  
Côte D’Ivoire ◽  
Western Blots ◽  
Ara H 2 ◽  
Ara H 1 ◽  
Sds Page ◽  
Ara H 3 ◽  
Peanut Allergens ◽  
The Usa ◽  
Peanut Cultivars

scholarly journals IgE cross-reactivity between the major peanut allergen Ara h 2 and the non-homologous allergens Ara h 1 and Ara h 3

2013 ◽  
Vol 3 (S3) ◽  
Author(s):  
M Bublin ◽  
M Kostadinova ◽  
C Radauer ◽  
C Hafner ◽  
Z Szépfalusi ◽  
...  
Keyword(s):  
Cross Reactivity ◽  
Peanut Allergen ◽  
Ara H 2 ◽  
Ara H 1 ◽  
Ara H 3

scholarly journals Simplified Methods for Purification of Peanut Allergenic Proteins: Ara h 1, Ara h 2, and Ara h 3

2014 ◽  
Vol 20 (4) ◽  
pp. 875-881 ◽  
Author(s):  
Keigo Masuyama ◽  
Kazutaka Yamamoto ◽  
Kaoru Ito ◽  
Eiichi Kitagawa ◽  
Kohji Yamaki
Keyword(s):  
Ara H 2 ◽  
Ara H 1 ◽  
Ara H 3 ◽  
Allergenic Proteins

Mixed antibody and T cell responses to peanut and the peanut allergens Ara h 1, Ara h 2, Ara h 3 and Ara h 6 in an oral sensitization model

2004 ◽  
Vol 34 (9) ◽  
pp. 1422-1428 ◽  
Author(s):  
F. van Wijk ◽  
S. Hartgring ◽  
S. J. Koppelman ◽  
R. Pieters ◽  
L. M. J. Knippels
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Ara H 2 ◽  
Cell Responses ◽  
Ara H 1 ◽  
Ara H 3 ◽  
Peanut Allergens ◽  
Ara H 6
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