scholarly journals ALVR109, an Off‐the‐Shelf Partially HLA Matched SARS‐CoV‐2‐Specific T Cell Therapy, to Treat Refractory Severe COVID‐19 Pneumonia in a Heart Transplant Patient: Case Report

2021 ◽  
Author(s):  
Katalin Martits‐Chalangari ◽  
Cedric W. Spak ◽  
Medhat Askar ◽  
Aaron Killian ◽  
Tammy L. Fisher ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Cell Therapy ◽  
Heart Transplant ◽  
Transplant Patient ◽  
Heart Transplant Patient ◽  
Patient Case ◽  
T Cell Therapy

Pulmonary Nocardiosis in a Heart Transplant Patient: Case Report and Review of the Literature

2007 ◽  
Vol 26 (1) ◽  
pp. 93-97 ◽  
Author(s):  
François Haddad ◽  
Sharon A. Hunt ◽  
Mark Perlroth ◽  
Hannah Valantine ◽  
Ramona Doyle ◽  
...  
Keyword(s):  
Case Report ◽  
Heart Transplant ◽  
Transplant Patient ◽  
Heart Transplant Patient ◽  
Review Of The Literature ◽  
Patient Case ◽  
Pulmonary Nocardiosis

scholarly journals 4SCAR‐GD2‐modified T‐cell therapy in neuroblastoma with MYCN amplification: A case report with over 4‐year follow‐up data

2020 ◽  
Vol 4 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Xiao Xu ◽  
Wen Zhao ◽  
Zhixia Yue ◽  
Maoquan Qin ◽  
Mei Jin ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Cell Therapy ◽  
Mycn Amplification ◽  
T Cell Therapy

scholarly journals Cardiac amyloidosis in a heart transplant patient - A case report and retrospective analysis of amyloidosis evolution

2015 ◽  
Vol 4 (1) ◽  
pp. 60-64 ◽  
Author(s):  
Svetlana Kintsler ◽  
Jörg Jäkel ◽  
Vincent Brandenburg ◽  
Katrin Kersten ◽  
Ruth Knuechel ◽  
...  
Keyword(s):  
Case Report ◽  
Retrospective Analysis ◽  
Heart Transplant ◽  
Cardiac Amyloidosis ◽  
Transplant Patient ◽  
Heart Transplant Patient

scholarly journals Switching to tacrolimus extended-release improved the effectiveness of immunosuppressive therapy in a heart transplant patient: A case report

2012 ◽  
Vol 6 (1) ◽  
pp. e26-e29 ◽  
Author(s):  
Shinichi Nunoda ◽  
Kuniaki Suwa ◽  
Kazunobu Shitakura ◽  
Tomoko Kikuchi ◽  
Shun Nakajima ◽  
...  
Keyword(s):  
Case Report ◽  
Immunosuppressive Therapy ◽  
Heart Transplant ◽  
Extended Release ◽  
Transplant Patient ◽  
Heart Transplant Patient

scholarly journals Complete response to PD-1 blockade following EBV-specific T-cell therapy in metastatic nasopharyngeal carcinoma

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Corey Smith ◽  
Margaret McGrath ◽  
Michelle A. Neller ◽  
Katherine K. Matthews ◽  
Pauline Crooks ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Nasopharyngeal Carcinoma ◽  
Cell Therapy ◽  
Complete Response ◽  
Adoptive T Cell Therapy ◽  
Successful Implementation ◽  
Cell Repertoire ◽  
T Cell Therapy ◽  
Barr Virus

AbstractNasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV)-associated heterogeneous disease and is characterized by peritumoral immune infiltrate. Adoptive T-cell therapy (ACT) has emerged as a potential therapeutic strategy for NPC. However, the tumor microenvironment remains a major roadblock for the successful implementation of ACT in clinical settings. Expression of checkpoint molecules by malignant cells can inhibit the effector function of adoptively transferred EBV-specific T cells. Here we present a novel case report of a patient with metastatic NPC who was successfully treated with a combination of EBV-specific ACT and programmed cell death-1 blockade therapy. Following combination immunotherapy, the patient showed complete resolution of metastatic disease with no evidence of disease relapse for 22 months. Follow-up immunological analysis revealed dramatic restructuring of the global T-cell repertoire that was coincident with the clinical response. This case report provides an important platform for translating these findings to a larger cohort of NPC patients.

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