scholarly journals The negative impact of T‐cell mediated rejection on renal allograft survival in the modern era

2021 ◽  
Author(s):  
C Rampersad ◽  
R Balshaw ◽  
IW Gibson ◽  
J Ho ◽  
J Shaw ◽  
...  
Keyword(s):  
T Cell ◽  
Renal Allograft ◽  
Negative Impact ◽  
Allograft Survival ◽  
Modern Era

Evaluation of T-Cell Receptor Repertoires in Patients with Long-Term Renal Allograft Survival

2005 ◽  
Vol 5 (4) ◽  
pp. 746-756 ◽  
Author(s):  
Cristiam M. Alvarez ◽  
Gerhard Opelz ◽  
Mabel C. Giraldo ◽  
Steffen Pelzl ◽  
Fabrice Renner ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Renal Allograft ◽  
Cell Receptor ◽  
Allograft Survival

INDUCTION OF LONG-TERM RAT RENAL ALLOGRAFT SURVIVAL BY PRETRANSPLANT T CELL RECEPTOR-??/??-TARGETED THERAPY1

1996 ◽  
Vol 61 (2) ◽  
pp. 336-339 ◽  
Author(s):  
Claus-Dieter Heidecke ◽  
Niko Zantl ◽  
Stefan Maier ◽  
Alexandra Varzaru ◽  
Birgit Hager ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Renal Allograft ◽  
Cell Receptor ◽  
Allograft Survival

HIGHLY ALTERED T CELL RECEPTOR REPERTOIRES IN PATIENTS WITH LONG-TERM RENAL ALLOGRAFT SURVIVAL

2004 ◽  
Vol 78 ◽  
pp. 517
Author(s):  
C M Alvarez ◽  
G Opelz ◽  
M C Giraldo ◽  
S Pelzl ◽  
F Renner ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Renal Allograft ◽  
Cell Receptor ◽  
Allograft Survival

scholarly journals Improved renal allograft survival for pre-emptive paediatric renal transplant recipients in the UK

2021 ◽  
pp. archdischild-2020-321277
Author(s):  
Matko Marlais ◽  
Kate Martin ◽  
Stephen D Marks
Keyword(s):  
Peritoneal Dialysis ◽  
Renal Transplant ◽  
Renal Allograft ◽  
Cox Regression ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Allograft Survival ◽  
Significant Difference ◽  
Donor Type ◽  
The Uk

BackgroundThe aim of this study was to investigate whether being on dialysis at the time of renal transplantation affected renal allograft survival in paediatric renal transplant recipients (pRTRs).MethodsRetrospective study of UK Transplant Registry (National Health Service Blood and Transplant) data on all children (aged <18 years) receiving a kidney-only transplant from 1 January 2000 to 31 December 2015. Kaplan-Meier estimates of patient and renal allograft survival calculated and Cox regression modelling accounting for donor type. The relationship between time on dialysis and renal allograft survival was examined.Results2038 pRTRs were analysed: 607 (30%) were pre-emptively transplanted, 789 (39%) and 642 (32%) on peritoneal dialysis and haemodialysis, respectively, at the time of transplantation. Five-year renal allograft survival was significantly better in the pre-emptively transplanted group (90.6%) compared with those on peritoneal dialysis and haemodialysis (86.4% and 85.7%, respectively; p=0.02). After accounting for donor type, there was a significantly lower hazard of 5-year renal allograft failure in pre-emptively transplanted children (HR 0.742, p=0.05). Time spent on dialysis pre-transplant negatively correlated with renal allograft survival (p=0.002). There was no significant difference in 5-year renal allograft survival between children who were on dialysis for less than 6 months and children transplanted pre-emptively (87.5% vs 90.5%, p=0.25).ConclusionsPre-emptively transplanted children have improved 5-year renal allograft survival, compared with children on dialysis at the time of transplantation. Although increased time spent on dialysis correlated with poorer renal allograft survival, there was no evidence that short periods of dialysis pre-transplant affected renal allograft survival.

Sign in / Sign up

Export Citation Format

Share Document