scholarly journals Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: A scoping review

2021 ◽  
Author(s):  
Christian Appenzeller‐Herzog ◽  
Steffen Hartleif ◽  
Julien Vionnet
Keyword(s):  
Liver Transplantation ◽  
Scoping Review ◽  
Clinical Parameters ◽  
Operational Tolerance

scholarly journals Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol

F1000Research ◽  
2020 ◽  
Vol 8 ◽  
pp. 2059
Author(s):  
Christian Appenzeller-Herzog ◽  
Steffen Hartleif ◽  
Julien Vionnet
Keyword(s):  
Autoimmune Disease ◽  
Viral Hepatitis ◽  
Scoping Review ◽  
Data Extraction ◽  
Clinical Parameter ◽  
Cochrane Library ◽  
Narrative Form ◽  
Clinical Parameters ◽  
Clinical Trial Registries ◽  
Operational Tolerance

Objective: This scoping review aims at systematically mapping reported prognostic factors for spontaneous immunosuppression (IS) free allograft tolerance (operational tolerance, OT) in non-viral hepatitis and non-autoimmune disease liver transplant (LT) recipients who are undergoing immunosuppression withdrawal (ISW). The results may inform the subsequent conduct of a systematic review with a more specific review question. Background: LT is currently the most effective treatment for end-stage liver diseases. Whereas the short-term outcomes after LT have dramatically improved over the last decades, the long-term outcomes remain unsatisfactory, mainly because of side effects of lifelong IS, such as infections, cardiovascular diseases, malignancies, and nephrotoxicity. ISW studies have shown that OT can be achieved by a subset of LT recipients and recent research has identified biomarkers of OT in these patients. However, an evidence-based selection algorithm for patients that can predictably benefit from ISW is not available to date. The planned review will, therefore, map existing knowledge on prognostic clinical parameters and biomarkers for OT. Inclusion criteria: We will consider studies that record any clinical parameter or biomarker before the initiation of ISW in paediatric or adult non-viral hepatitis and non-autoimmune disease LT recipients and analyse their possible association with ISW outcomes (OT or non-tolerance). Studies addressing the effectiveness of OT-inducing treatments will be excluded. Methods: Embase, MEDLINE, and Cochrane Library will be searched for relevant articles or conference abstracts. Full-texts of selected abstracts will be independently screened for inclusion by two reviewers. References and citing articles of included records will be screened for additional relevant records. Clinical trial registries will be searched for ongoing studies, and their investigators contacted for the sharing of unpublished data. Data from included records will be independently extracted by two reviewers using a prespecified data extraction table and presented in both tabular and narrative form.

scholarly journals Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol

F1000Research ◽  
2020 ◽  
Vol 8 ◽  
pp. 2059
Author(s):  
Christian Appenzeller-Herzog ◽  
Steffen Hartleif ◽  
Julien Vionnet
Keyword(s):  
Autoimmune Disease ◽  
Viral Hepatitis ◽  
Scoping Review ◽  
Data Extraction ◽  
Clinical Parameter ◽  
Cochrane Library ◽  
Narrative Form ◽  
Clinical Parameters ◽  
Clinical Trial Registries ◽  
Operational Tolerance

Objective: This scoping review aims at systematically mapping reported prognostic factors for spontaneous immunosuppression (IS) free allograft tolerance (operational tolerance, OT) in non-viral hepatitis and non-autoimmune disease liver transplant (LT) recipients who are undergoing immunosuppression withdrawal (ISW). The results may inform the subsequent conduct of a systematic review with a more specific review question. Background: LT is currently the most effective treatment for end-stage liver diseases. Whereas the short-term outcomes after LT have dramatically improved over the last decades, the long-term outcomes remain unsatisfactory, mainly because of side effects of lifelong IS, such as infections, cardiovascular diseases, malignancies, and nephrotoxicity. ISW studies have shown that OT can be achieved by a subset of LT recipients and recent research has identified biomarkers of OT in these patients. However, an evidence-based selection algorithm for patients that can predictably benefit from ISW is not available to date. The planned review will, therefore, map existing knowledge on prognostic clinical parameters and biomarkers for OT. Inclusion criteria: We will consider studies that record any clinical parameter or biomarker before the initiation of ISW in paediatric or adult non-viral hepatitis and non-autoimmune disease LT recipients and analyse their possible association with ISW outcomes (OT or non-tolerance). Studies addressing the effectiveness of OT-inducing treatments will be excluded. Methods: Embase, MEDLINE, and Cochrane Library will be searched for relevant articles or conference abstracts. Full-texts of selected abstracts will be independently screened for inclusion by two reviewers. References and citing articles of included records will be screened for additional relevant records. Clinical trial registries will be searched for ongoing studies, and their investigators contacted for the sharing of unpublished data. Data from included records will be independently extracted by two reviewers using a prespecified data extraction table and presented in both tabular and narrative form.

scholarly journals Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 2059
Author(s):  
Christian Appenzeller-Herzog ◽  
Steffen Hartleif ◽  
Julien Vionnet
Keyword(s):  
Autoimmune Disease ◽  
Viral Hepatitis ◽  
Scoping Review ◽  
Data Extraction ◽  
Clinical Parameter ◽  
Cochrane Library ◽  
Narrative Form ◽  
Clinical Parameters ◽  
Clinical Trial Registries ◽  
Operational Tolerance

Objective: This scoping review aims at systematically identifying prognostic factors for spontaneous immunosuppression (IS) free allograft tolerance (operational tolerance, OT) in non-viral hepatitis and non-autoimmune disease liver transplant (LT) recipients who are undergoing immunosuppression withdrawal (ISW). The results may inform the subsequent conduct of a systematic review with a more specific review question. Background: LT is currently the most effective treatment for end-stage liver diseases. Whereas the short-term outcomes after LT have dramatically improved over the last decades, the long-term outcomes remain unsatisfactory, mainly because of side effects of lifelong IS, such as infections, cardiovascular diseases, malignancies, and nephrotoxicity. ISW studies have shown that OT can be achieved by a subset of LT recipients and recent research has identified biomarkers of OT in these patients. However, an evidence-based selection algorithm for patients that can predictably benefit from ISW is not available to date. The planned review will, therefore, map existing knowledge on prognostic clinical parameters and biomarkers for OT. Inclusion criteria: We will consider studies that record any clinical parameter or biomarker before the initiation of ISW in non-viral hepatitis and non-autoimmune disease LT recipients and analyse their possible association with ISW outcomes (OT or non-tolerance). Studies addressing the effectiveness of OT-inducing treatments will be excluded. Methods: Embase, MEDLINE, and Cochrane Library will be searched for relevant articles or conference abstracts. Full-texts of selected abstracts will be independently screened for inclusion by two reviewers. References and citing articles of included records will be screened for additional relevant records. Clinical trial registries will be searched for ongoing studies, and their investigators contacted for the sharing of unpublished data. Data from included records will be independently extracted by two reviewers using a prespecified data extraction table and presented in both tabular and narrative form.

Transfusion-related Acute Lung Injury during Liver Transplantation: A Scoping Review

2021 ◽  
Author(s):  
ManNoj H. Iyer ◽  
Julia E. Kumar ◽  
Nicolas Kumar ◽  
Leonid Gorelik ◽  
Nasir Hussain ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Scoping Review

Predicting Operational Tolerance in Pediatric Living-Donor Liver Transplantation by Absence of HLA Antibodies

2013 ◽  
Vol 95 (1) ◽  
pp. 177-183 ◽  
Author(s):  
Kayo Waki ◽  
Yasuhiko Sugawara ◽  
Koichi Mizuta ◽  
Michiko Taniguchi ◽  
Miyuki Ozawa ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Donor Liver ◽  
Hla Antibodies ◽  
Donor Liver Transplantation ◽  
Operational Tolerance

scholarly journals Operational tolerance after liver transplantation, more common than we think: A case report

2011 ◽  
Vol 10 (3) ◽  
pp. 361-364 ◽  
Author(s):  
Carlos Benítez ◽  
Juan Pablo Arancibia ◽  
Marco Arrese ◽  
Alejandro Soza ◽  
Pilar Domínguez ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Case Report ◽  
Operational Tolerance

scholarly journals Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation

2012 ◽  
Vol 122 (1) ◽  
pp. 368-382 ◽  
Author(s):  
Felix Bohne ◽  
Marc Martínez-Llordella ◽  
Juan-José Lozano ◽  
Rosa Miquel ◽  
Carlos Benítez ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Human Liver ◽  
Iron Homeostasis ◽  
Operational Tolerance ◽  
Expression Of Genes
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