scholarly journals Effect of delayed graft function on longer‐term outcomes after kidney transplantation from donation after circulatory death donors in the UK: a national cohort study

2021 ◽  
Author(s):  
Benedict L. Phillips ◽  
Maria Ibrahim ◽  
George Greenhall ◽  
Lisa Mumford ◽  
Anthony Dorling ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kidney Transplantation ◽  
Graft Function ◽  
Delayed Graft Function ◽  
Donation After Circulatory Death ◽  
National Cohort ◽  
The Uk ◽  
Circulatory Death

scholarly journals MP702ACUTE KIDNEY INJURY AS DELAYED GRAFT FUNCTION IN DONATION AFTER CIRCULATORY DEATH KIDNEY TRANSPLANTATION: UK SINGLE CENTRE STUDY

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i573-i573
Author(s):  
Ilaria Umbro ◽  
Anna Paola Mitterhofer ◽  
Francesca Tinti ◽  
Felicity Evison ◽  
James Ferguson ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Function ◽  
Kidney Injury ◽  
Delayed Graft Function ◽  
Donation After Circulatory Death ◽  
Single Centre ◽  
Centre Study ◽  
Single Centre Study ◽  
Circulatory Death

scholarly journals Intraoperative Verapamil Fails to Reduce Delayed Graft Function in Donation After Circulatory Death Renal Allografts

2022 ◽  
Vol 8 (2) ◽  
pp. e1250
Author(s):  
Jessica T. Lovett ◽  
Jeffrey Stern ◽  
Elaina P. Weldon ◽  
Bonnie E. Lonze ◽  
Zoe A. Stewart
Keyword(s):  
Graft Function ◽  
Delayed Graft Function ◽  
Donation After Circulatory Death ◽  
Renal Allografts ◽  
Circulatory Death

scholarly journals Donor Age, Cold Ischemia Time, and Delayed Graft Function

2020 ◽  
Vol 15 (6) ◽  
pp. 813-821 ◽  
Author(s):  
Ilkka Helanterä ◽  
Hassan N. Ibrahim ◽  
Marko Lempinen ◽  
Patrik Finne
Keyword(s):  
Graft Function ◽  
The United States ◽  
Delayed Graft Function ◽  
Cold Ischemia Time ◽  
Donation After Circulatory Death ◽  
Donor Age ◽  
Cold Ischemia ◽  
Kidney Donor ◽  
Ischemia Time ◽  
Circulatory Death

Background and objectivesIncreased donor age is one of the most important risk factors for delayed graft function (DGF), and previous studies suggest that the harmful effect of cold ischemia time is increased in kidneys from older donors. Our aim was to study the association of increased donor age and cold ischemia time with the risk of delayed graft function in a large cohort kidney transplants from the current era.Design, setting, participants, & measurementsThe Scientific Registry of Transplant Recipients was used for this observational, retrospective registry analysis to identify all deceased donor kidney transplantations in the United States between 2010 and September 2018, who were on dialysis pretransplantation (n=90,810). The association of donor age and cold ischemia time with the risk of DGF was analyzed in multivariable models adjusted for recipient characteristics (age, race, sex, diabetes, calculated panel-reactive antibodies, pretransplant dialysis duration) and donor characteristics (cause of death, sex, race, body mass index, creatinine, donation after circulatory death status, history of hypertension, and HLA mismatch).ResultsCold ischemia time and donor age were independently associated with the risk of DGF, but the risk of DGF was not statistically significantly lower in donor age categories between 50 and 64 years, compared with donors ≥65 years. The harmful association of cold ischemia time was not higher in kidneys from older donors in any age category, not even among donation after circulatory death donors. When donor risk was assessed with kidney donor profile index, although a statistically significant interaction with cold ischemia time was found, no practically meaningful increase in cold-ischemia susceptibility of kidneys with a high kidney donor profile index was found.ConclusionsWe were unable to demonstrate an association between donor age and DGF. The association of longer cold ischemia time with the risk of DGF was not magnified in older or more marginal donors.

scholarly journals Continuous Normothermic Ex Vivo Kidney Perfusion Improves Graft Function in Donation After Circulatory Death Pig Kidney Transplantation

2017 ◽  
Vol 101 (4) ◽  
pp. 754-763 ◽  
Author(s):  
J. Moritz Kaths ◽  
Juan Echeverri ◽  
Yi Min Chun ◽  
Jun Yu Cen ◽  
Nicolas Goldaracena ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Ex Vivo ◽  
Graft Function ◽  
Donation After Circulatory Death ◽  
Pig Kidney ◽  
Kidney Perfusion ◽  
Circulatory Death

scholarly journals Outcomes of transplantation of livers from donation after circulatory death donors in the UK: a cohort study

BMJ Open ◽  
2013 ◽  
Vol 3 (9) ◽  
pp. e003287 ◽  
Author(s):  
Christopher J Callaghan ◽  
Susan C Charman ◽  
Paolo Muiesan ◽  
James J Powell ◽  
Alexander E Gimson ◽  
...  
Keyword(s):  
Cohort Study ◽  
Donation After Circulatory Death ◽  
The Uk ◽  
Circulatory Death
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