scholarly journals Cryptococcus transmission through solid organ transplantation in the United States: A Report from the Ad Hoc Disease Transmission Advisory Committee

2020 ◽  
Author(s):  
Lasya R. Penumarthi ◽  
Ricardo M. La Hoz ◽  
Cameron R. Wolfe ◽  
Brendan R. Jackson ◽  
Aneesh K. Mehta ◽  
...  
Keyword(s):  
United States ◽  
Advisory Committee ◽  
Organ Transplantation ◽  
Disease Transmission ◽  
Ad Hoc ◽  
Solid Organ Transplantation ◽  
The United States ◽  
Solid Organ

scholarly journals 1733. 10 Years of DTAC Experience With Donor-Derived Cryptococcus Transmission in Solid-Organ Transplantation in the United States

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S59-S59
Author(s):  
Aneesh K Mehta ◽  
Maricar Malinis ◽  
Gabriel Vece ◽  
Lara Danziger-Isakov ◽  
Diana F Florescu ◽  
...  
Keyword(s):  
Organ Transplantation ◽  
Disease Transmission ◽  
Ad Hoc ◽  
Clinical Symptoms ◽  
Solid Organ Transplantation ◽  
Case Series ◽  
The United States ◽  
Unknown Etiology ◽  
Solid Organ ◽  
Potential Donor

Abstract Background Cryptococcosis is an important fungal complication of solid organ transplantation (SOT); cases occurring within 6 months posttransplant are often severe and sometimes donor derived. Morbidity can be related to delayed recognition of clinical symptoms or lack of communications among the SOT recipient centers. To better understand transmission of Cryptococcus (Crypto) and to identify opportunities for improved identification and communication, all potential donor-derived transmission events (PDDTE) of Crypto reported to OPTN/UNOS ad hoc Disease Transmission Advisory Committee (DTAC) over 10 years were analyzed. Methods All Crypto cases reported to DTAC between January 2008 and December 2017 were reviewed retrospectively as potential donor-derived transmission events (PDDTE). Likelihood of donor-derivation was adjudicated based on recipient and donor data. Results Fourty-six cases of Crypto were reported to DTAC during this period, involving 145 SOT recipients. Of the Proven or Probable donor-derived Crypto cases (n = 9), transmission occurred in 15 recipients; 2 donors each transmitted Crypto to 3 different recipients. Of the Possible cases, 9 recipients were affected. Six recipients with PDDTE Crypto died. Eight recipients received antifungal medications that would prevent transmission of Crypto (classified as intervention without disease transmission). UNOS Region 7 had the highest number donors with 10, with 6 and 7 from Regions 2 and 3, respectively. No cases C. gattii were reported; however, most of the reports to DTAC did not discriminate between C. neoformans and C. gattii. Conclusion This DTAC case series highlights both donor and recipient-derived cryptococcal infections and their potential to have devastating clinical impact. These data also highlight important delays in recognizing Crypto in SOT and in communicating these results to other centers when a PDDTE is possible. Transplant teams should have a high level of suspicion for Crypto in SOT, particularly in those with fever of unknown etiology, pulmonary infiltrates, headaches, and mental status changes. In the future, it may be helpful for transplant center to perform specific testing to discriminate between Cryptococcus species to understand their differential impact in SOT. Disclosures D. F. Florescu, Astellas: Grant Investigator, Grant recipient. C. R. Wolfe, Merck: Scientific Advisor, Consulting fee.

scholarly journals Risk of Kaposi sarcoma after solid organ transplantation in the United States

2018 ◽  
Vol 143 (11) ◽  
pp. 2741-2748 ◽  
Author(s):  
Elizabeth K. Cahoon ◽  
Martha S. Linet ◽  
Christina A. Clarke ◽  
Karen S. Pawlish ◽  
Eric A. Engels ◽  
...  
Keyword(s):  
United States ◽  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Kaposi Sarcoma ◽  
The United States ◽  
Solid Organ

scholarly journals Risk of diffuse large B-cell lymphoma after solid organ transplantation in the United States

2014 ◽  
Vol 89 (7) ◽  
pp. 714-720 ◽  
Author(s):  
Todd M. Gibson ◽  
Eric A. Engels ◽  
Christina A. Clarke ◽  
Charles F. Lynch ◽  
Dennis D. Weisenburger ◽  
...  
Keyword(s):  
United States ◽  
B Cell ◽  
Organ Transplantation ◽  
Cell Lymphoma ◽  
Solid Organ Transplantation ◽  
B Cell Lymphoma ◽  
The United States ◽  
Solid Organ ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Risk of lymphoma subtypes after solid organ transplantation in the United States

2013 ◽  
Vol 109 (1) ◽  
pp. 280-288 ◽  
Author(s):  
C A Clarke ◽  
L M Morton ◽  
C Lynch ◽  
R M Pfeiffer ◽  
E C Hall ◽  
...  
Keyword(s):  
United States ◽  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
The United States ◽  
Solid Organ

scholarly journals HPV-Related Cancers After Solid Organ Transplantation in the United States

2013 ◽  
Vol 13 (12) ◽  
pp. 3202-3209 ◽  
Author(s):  
M. M. Madeleine ◽  
J. L. Finch ◽  
C. F. Lynch ◽  
M. T. Goodman ◽  
E. A. Engels
Keyword(s):  
United States ◽  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
The United States ◽  
Solid Organ

Approaching a Consensus: Psychosocial Support Services for Solid Organ Transplantation Programs

2001 ◽  
Vol 11 (3) ◽  
pp. 163-168 ◽  
Author(s):  
Christine E. Skotzko ◽  
Judith A. Stowe ◽  
Carol Wright ◽  
Kay Kendall ◽  
Mary Amanda Dew
Keyword(s):  
United States ◽  
Organ Transplantation ◽  
Support Services ◽  
Psychosocial Support ◽  
Solid Organ Transplantation ◽  
The United States ◽  
Solid Organ ◽  
Psychosocial Needs ◽  
Psychosocial Services ◽  
Transplant Patients

Background— Solid organ transplantation has become an accepted treatment for individuals with end-stage organ dysfunction. Criteria are being developed in the United States to determine medical eligibility for transplant candidates and competencies for transplant centers and physicians. To date, similar criteria for psychosocial services have not been developed. Design and Setting— We queried participants in a specialty psychosocial transplant meeting to determine their views of which psychosocial services are essential to the comprehensive care of transplant patients in the United States. Results— There was broad based multidisciplinary support for proactive pretransplant screening to discern individual psychosocial needs; focused pretransplant interventions to improve candidacy and future compliance; and posttransplant programs that address psychosocial, rehabilitation, and financial issues. Conclusion— Among psychosocial providers of solid organ transplantation services, there is support for expanding routine screening and support services to individuals who are candidates for and undergo solid organ transplantation.

scholarly journals Impact of Drug Overdose Deaths on Solid Organ Transplantation in the United States

2018 ◽  
Vol 33 (9) ◽  
pp. 1423-1425 ◽  
Author(s):  
George Cholankeril ◽  
Andrew A. Li ◽  
Rosann Cholankeril ◽  
Alice E. Toll ◽  
Jeffrey S. Glenn ◽  
...  
Keyword(s):  
United States ◽  
Organ Transplantation ◽  
Drug Overdose ◽  
Solid Organ Transplantation ◽  
The United States ◽  
Solid Organ ◽  
Overdose Deaths
Sign in / Sign up

Export Citation Format

Share Document