scholarly journals Burden, epidemiology, and outcomes of microbiologically confirmed respiratory viral infections in solid organ transplant recipients: a nationwide, multi‐season prospective cohort study

2020 ◽  
Author(s):  
Matteo Mombelli ◽  
Brian M. Lang ◽  
Dionysios Neofytos ◽  
John‐David Aubert ◽  
Christian Benden ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Viral Infections ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Solid Organ Transplant Recipients ◽  
Respiratory Viral Infections

scholarly journals Rationale and design of TransplantLines: a prospective cohort study and biobank of solid organ transplant recipients

BMJ Open ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. e024502 ◽  
Author(s):  
Michele F Eisenga ◽  
Antonio W Gomes-Neto ◽  
Marco van Londen ◽  
Aaltje L Ziengs ◽  
Rianne M Douwes ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Psychological Functioning ◽  
Prospective Cohort ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

IntroductionIn the past decades, short-term results after solid organ transplantation have markedly improved. Disappointingly, this has not been accompanied by parallel improvements in long-term outcomes after transplantation. To improve graft and recipient outcomes, identification of potentially modifiable risk factors and development of biomarkers are required. We provide the rationale and design of a large prospective cohort study of solid organ transplant recipients (TransplantLines).Methods and analysisTransplantLines is designed as a single-centre, prospective cohort study and biobank including all different types of solid organ transplant recipients as well as living organ donors. Data will be collected from transplant candidates before transplantation, during transplantation, at 3 months, 6 months, 1 year, 2 years and 5 years, and subsequently every 5 years after transplantation. Data from living organ donors will be collected before donation, during donation, at 3 months, 1 year and 5 years after donation, and subsequently every 5 years. The primary outcomes are mortality and graft failure. The secondary outcomes will be cause-specific mortality, cause-specific graft failure and rejection. The tertiary outcomes will be other health problems, including diabetes, obesity, hypertension, hypercholesterolaemia and cardiovascular disease, and disturbances that relate to quality of life, that is, physical and psychological functioning, including quality of sleep, and neurological problems such as tremor and polyneuropathy.Ethics and disseminationEthical approval has been obtained from the relevant local ethics committee. The TransplantLines cohort study is designed to deliver pioneering insights into transplantation and donation outcomes. The study design allows comprehensive data collection on perioperative care, nutrition, social and psychological functioning, and biochemical parameters. This may provide a rationale for future intervention strategies to more individualised, patient-centred transplant care and individualisation of treatment.Trial registration numberNCT03272841.

scholarly journals COVID‐19 in solid organ transplant recipients: A national cohort study from Sweden

2021 ◽  
Author(s):  
John Mackay Søfteland ◽  
Gustav Friman ◽  
Bengt von Zur‐Mühlen ◽  
Bo‐Göran Ericzon ◽  
Carin Wallquist ◽  
...  
Keyword(s):  
Cohort Study ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
National Cohort ◽  
Solid Organ Transplant Recipients

Prevention of viral infections in families of recipients of solid organs

2021 ◽  
pp. 20-22
Author(s):  
M. M. Kaabak ◽  
N. N. Rappoport ◽  
Yu. N. Vyunkova ◽  
Yu. B. Shepetun ◽  
A. G. Trofimova ◽  
...  
Keyword(s):  
Viral Infections ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Antiviral Prophylaxis ◽  
Transplant Recipients ◽  
Living Together ◽  
Solid Organ Transplant Recipients ◽  
Febrile Episodes ◽  
Second Wave

Current COVID-19 pandemic demands improvements in antiviral prophylaxis. Tyloron, as biological interferon activator, has been synthesized in the 70th of previous century. We used Tyloron in 60 patients – relatives and partners living together with solid organ transplant recipients – in autumn 2020, during second wave of the SARS-CoV‑2 pandemic. Results were compared with 60 patients used other means of antiviral prophylaxis. In patients taking Tyloron the number of febrile episodes was significantly lower (р < 0.02).

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