scholarly journals The 2020 Vision of “Infectious Tolerance” in Transplantation

2020 ◽  
Vol 20 (12) ◽  
pp. 3273-3273
Author(s):  
Xian C. Li
Keyword(s):  
Infectious Tolerance

scholarly journals Interleukin 35: A Key Mediator of Suppression and the Propagation of Infectious Tolerance

2013 ◽  
Vol 4 ◽  
Author(s):  
Brian M. Olson ◽  
Jeremy A. Sullivan ◽  
William J. Burlingham
Keyword(s):  
Infectious Tolerance

Th2-LIKE REGULATORY T CELLS IN THE INFECTIOUS TOLERANCE PATHWAY

1999 ◽  
Vol 67 (9) ◽  
pp. S607
Author(s):  
Y. Zhai ◽  
H. Kato ◽  
J. Li ◽  
R. W. Busuttil ◽  
J. W. Kupiec-Weglinski
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Infectious Tolerance

scholarly journals Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance

2011 ◽  
Vol 208 (10) ◽  
pp. 2043-2053 ◽  
Author(s):  
Adrian R. Kendal ◽  
Ye Chen ◽  
Frederico S. Regateiro ◽  
Jianbo Ma ◽  
Elizabeth Adams ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Tissue Damage ◽  
Paradigm Shift ◽  
Effector T Cells ◽  
Transplantation Tolerance ◽  
Self Tolerance ◽  
Infectious Tolerance ◽  
First Time

A paradigm shift in immunology has been the recent discovery of regulatory T cells (T reg cells), of which CD4+Foxp3+ cells are proven as essential to self-tolerance. Using transgenic B6.Foxp3hCD2 mice to isolate and ablate Foxp3+ T reg cells with an anti-hCD2 antibody, we show for the first time that CD4+Foxp3+ cells are crucial for infectious tolerance induced by nonablative anti–T cell antibodies. In tolerant animals, Foxp3+ T reg cells are constantly required to suppress effector T cells still capable of causing tissue damage. Tolerated tissue contains T cells that are capable of rejecting it, but are prevented from doing so by therapeutically induced Foxp3+ T reg cells. Finally, Foxp3+ cells have been confirmed as the critical missing link through which infectious tolerance operates in vivo. Peripherally induced Foxp3+ cells sustain tolerance by converting naive T cells into the next generation of Foxp3+ cells. Empowering Foxp3+ regulatory T cells in vivo offers a tractable route to avoid and correct tissue immunopathology.

scholarly journals Infectious Tolerance

2002 ◽  
Vol 196 (2) ◽  
pp. 255-260 ◽  
Author(s):  
Helmut Jonuleit ◽  
Edgar Schmitt ◽  
Hacer Kakirman ◽  
Michael Stassen ◽  
Jürgen Knop ◽  
...  
Keyword(s):  
T Cells ◽  
Treg Cell ◽  
Cd4 T Cells ◽  
Transforming Growth Factor ◽  
Treg Cells ◽  
Cell Contact ◽  
Th Cells ◽  
Self Tolerance ◽  
Infectious Tolerance ◽  
Membrane Bound

Regulatory CD4+CD25+ T cells (Treg) are mandatory for maintaining immunologic self-tolerance. We demonstrate that the cell-cell contact–mediated suppression of conventional CD4+ T cells by human CD25+ Treg cells is fixation resistant, independent from membrane-bound TGF-β but requires activation and protein synthesis of CD25+ Treg cells. Coactivation of CD25+ Treg cells with Treg cell–depleted CD4+ T cells results in anergized CD4+ T cells that in turn inhibit the activation of conventional, freshly isolated CD4+ T helper (Th) cells. This infectious suppressive activity, transferred from CD25+ Treg cells via cell contact, is cell contact–independent and partially mediated by soluble transforming growth factor (TGF)-β. The induction of suppressive properties in conventional CD4+ Th cells represents a mechanism underlying the phenomenon of infectious tolerance. This explains previously published conflicting data on the role of TGF-β in CD25+ Treg cell–induced immunosuppression.

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