scholarly journals Author response to comments on economic analysis of subclinical rejection screening in kidney transplantation

2020 ◽  
Author(s):  
Chethan M. Puttarajappa ◽  
Rajil B. Mehta ◽  
Sundaram Hariharan
Keyword(s):  
Kidney Transplantation ◽  
Economic Analysis ◽  
Author Response ◽  
Subclinical Rejection

scholarly journals Economic analysis of screening for subclinical rejection in kidney transplantation using protocol biopsies and noninvasive biomarkers

2020 ◽  
Vol 21 (1) ◽  
pp. 186-197
Author(s):  
Chethan M. Puttarajappa ◽  
Rajil B. Mehta ◽  
Mark S. Roberts ◽  
Kenneth J. Smith ◽  
Sundaram Hariharan
Keyword(s):  
Kidney Transplantation ◽  
Economic Analysis ◽  
Protocol Biopsies ◽  
Subclinical Rejection ◽  
Noninvasive Biomarkers

Clinical and Economic Analysis of Delayed Administration of Antithymocyte Globulin for Induction Therapy in Kidney Transplantation

2013 ◽  
Vol 23 (1) ◽  
pp. 33-38 ◽  
Author(s):  
John W. McGillicuddy ◽  
David J. Taber ◽  
Nicole A. Pilch ◽  
Ryan K. Kohout ◽  
Charles F. Bratton ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Economic Analysis ◽  
Induction Therapy ◽  
Antithymocyte Globulin

scholarly journals P1643TORQUE TENO VIRUS FOR RISK STRATIFICATION OF SUBCLINICAL GRAFT REJECTION AFTER KIDNEY TRANSPLANTATION- A PROSPECTIVE STUDY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Konstantin Doberer ◽  
Georg A Böhmig ◽  
Elisabeth Puchhammer-Stöckl ◽  
Gregor Bond
Keyword(s):  
Kidney Transplantation ◽  
Graft Rejection ◽  
Graft Function ◽  
Type I ◽  
Kidney Graft ◽  
Protocol Biopsy ◽  
Patients At Risk ◽  
Subclinical Rejection ◽  
High Level ◽  
A Prospective Study

Abstract Background and Aims Non-invasive monitoring strategies are insufficient to detect patients at risk for subclinical graft rejection after kidney transplantation. The highly prevalent and non-pathogenic Torque Teno virus (TTV) reflects the immunocompetence of its host: high level viraemia indicates strong and low level viraemia weak immunosuppression, respectively. Thus TTV replication might serve as a candidate for immunologic monitoring. Method To analyze the association between TTV and subclinical kidney graft rejection, an interim analysis of the prospective “TTV POET” cohort study (DRKS00012335) was performed including data available until 31/01/2019. All consecutive kidney graft recipients transplanted at the Medical University Vienna since 01/12/2016 (n=308) with a protocol biopsy 12 months after transplantation (n=47; median 12.4 months) and stable graft function were included. Biopsy results according to current BANFF classification were analyzed in the context of peripheral blood TTV levels quantified by PCR. Results Graft function was excellent (median eGFR MDRD: 57 ml/min/1.73m2, urinary PKR: 92 mg/g). Twenty recipients (43%) had subclinical rejection (borderline TCMR, n=16; ABMR, n=3; TCMR type I, n=1). TTV level quantified at the date of biopsy was lower in recipients with rejection compared to recipients without rejection. The risk for rejection increased by 11% with each log level decrease in TTV copies/ml (RR 0.89, 95% CI 0.85-0.93; p<0.001). Differences in TTV levels were evident not only at the date of biopsy, but already 6 weeks earlier. Patients with biopsies showing chronic leasons, suggesting ongoing allo-reactivity, had a longer period of time with TTV levels <1x106 copies/ml. Conclusion Our data suggests an association between TTV level and subclinical graft rejection at 12 months after kidney transplantation. Future clinical trials are necessary to test the potential of TTV guided immunosuppression to reduce subclinical rejection.

AN ECONOMIC ANALYSIS OF KIDNEY TRANSPLANTATION

1998 ◽  
Vol 78 (1) ◽  
pp. 149-174 ◽  
Author(s):  
Roger W. Evans ◽  
Daniel J. Kitzmann
Keyword(s):  
Kidney Transplantation ◽  
Economic Analysis

Post-transplant soluble CD30 levels are associated with early subclinical rejection in kidney transplantation

2015 ◽  
Vol 32 (2) ◽  
pp. 61-65 ◽  
Author(s):  
Patricia C. Grenzi ◽  
Érika F. Campos ◽  
Hélio T. Silva Jr. ◽  
Claudia R. Felipe ◽  
Marcelo F. Franco ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Post Transplant ◽  
Soluble Cd30 ◽  
Subclinical Rejection

scholarly journals Impact of treatment of subclinical rejection at 2 weeks after kidney transplantation, compared by analysis of 1-year histologic outcomes

2020 ◽  
Vol 34 (1) ◽  
pp. S1-S1
Author(s):  
Okjoo Lee ◽  
Kyo Won Lee ◽  
Jae Berm Park ◽  
Jung Eun Lee ◽  
Na Young Hwang ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Subclinical Rejection

scholarly journals A Practical Guide to the Clinical Implementation of Biomarkers for Subclinical Rejection Following Kidney Transplantation

2020 ◽  
Vol 104 (4) ◽  
pp. 700-707 ◽  
Author(s):  
Maarten Naesens ◽  
John Friedewald ◽  
Valeria Mas ◽  
Bruce Kaplan ◽  
Michael M. Abecassis
Keyword(s):  
Kidney Transplantation ◽  
Clinical Implementation ◽  
Practical Guide ◽  
Subclinical Rejection
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