scholarly journals Cutaneous leukocyte lineages in tolerant large animal and immunosuppressed clinical vascularized composite allograft recipients

2020 ◽  
Author(s):  
David A. Leonard ◽  
Harrison R. Powell ◽  
Matthew W. Defazio ◽  
Kumaran Shanmugarajah ◽  
Melissa Mastroianni ◽  
...  
Keyword(s):  
Large Animal ◽  
Vascularized Composite Allograft

scholarly journals 2523: Vascularized composite allograft tolerance with transient high-dose tacrolimus across a full MHC mismatch in a large animal model

2016 ◽  
Vol 3 (1-2) ◽  
pp. 8-8 ◽  
Author(s):  
Howard D. Wang ◽  
Edward W. Swanson ◽  
Hsu-Tang Cheng ◽  
Jeffrey Walch ◽  
Jose C. Alonso-Escalante ◽  
...  
Keyword(s):  
Animal Model ◽  
Large Animal Model ◽  
High Dose ◽  
Large Animal ◽  
Vascularized Composite Allograft

scholarly journals Vascularized Composite Allograft Tolerance Across MHC Barriers in a Large Animal Model

2014 ◽  
Vol 14 (2) ◽  
pp. 343-355 ◽  
Author(s):  
D. A. Leonard ◽  
J. M. Kurtz ◽  
C. Mallard ◽  
A. Albritton ◽  
R. Duran-Struuck ◽  
...  
Keyword(s):  
Animal Model ◽  
Large Animal Model ◽  
Large Animal ◽  
Vascularized Composite Allograft

scholarly journals Clinical and preclinical tolerance protocols for vascularized composite allograft transplantation

2021 ◽  
Vol 48 (6) ◽  
pp. 703-713
Author(s):  
Jerry Huanda Yang ◽  
Ariel C. Johnson ◽  
Salih Colakoglu ◽  
Christene A. Huang ◽  
David Woodbridge Mathes
Keyword(s):  
Radiation Treatment ◽  
Immunosuppressive Treatment ◽  
Tolerance Induction ◽  
Human Leukocyte ◽  
Donor Cell ◽  
Large Animal ◽  
Valuable Insight ◽  
Widespread Application ◽  
Large Animal Models ◽  
Vascularized Composite Allograft

The field of vascularized composite allografts (VCAs) has undergone significant advancement in recent decades, and VCAs are increasingly common and accepted in the clinical setting, bringing hope of functional recovery to patients with debilitating injuries. A major obstacle facing the widespread application of VCAs is the side effect profile associated with the current immunosuppressive regimen, which can cause a wide array of complications such as infection, malignancy, and even death. Significant concerns remain regarding whether the treatment outweighs the risk. The potential solution to this dilemma would be achieving VCA tolerance, which would allow recipients to receive allografts without significant immunosuppression and its sequelae. Promising tolerance protocols are being studied in kidney transplantation; four major trials have attempted to withdraw immunosuppressive treatment with various successes. The common theme in all four trials is the use of radiation treatment and donor cell transplantation. The knowledge gained from these trials can provide valuable insight into the development of a VCA tolerance protocol. Despite similarities, VCAs present additional barriers compared to kidney allografts regarding tolerance induction. VCA donors are likely to be deceased, which limits the time for significant pre-conditioning. VCA donors are also more likely to be human leukocyte antigen–mismatched, which means that tolerance must be induced across major immunological barriers. This review also explores adjunct therapies studied in large animal models that could be the missing element in establishing a safe and stable tolerance induction method.

Stabilizing decellularized allogeneic aortic grafts by magnesium clips. First results of a large animal trial

2012 ◽  
Vol 60 (S 01) ◽  
Author(s):  
T Schilling ◽  
C Biskup ◽  
G Brandes ◽  
C Hinz ◽  
KT Kaufeld ◽  
...  
Keyword(s):  
Large Animal ◽  
Animal Trial ◽  
First Results

DEVELOPMENT OF A LARGE ANIMAL MODEL OF OPIATE ADDICTION TO EVALUATE CARDIOVASCULAR FUNCTION.

Analgesia ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 598-602 ◽  
Author(s):  
L.D. Napier ◽  
Z. Mateo ◽  
D.A. Yoshishige ◽  
B.A. Barron ◽  
J.L. Caffrey
Keyword(s):  
Animal Model ◽  
Cardiovascular Function ◽  
Large Animal Model ◽  
Opiate Addiction ◽  
Large Animal
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