scholarly journals Predictor parameters of liver viability during porcine normothermic ex situ liver perfusion in a model of liver transplantation with marginal grafts

2019 ◽  
Vol 19 (11) ◽  
pp. 2991-3005 ◽  
Author(s):  
Ivan Linares‐Cervantes ◽  
Juan Echeverri ◽  
Stuart Cleland ◽  
Johann Moritz Kaths ◽  
Roizar Rosales ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Perfusion ◽  
Ex Situ ◽  
Marginal Grafts ◽  
Liver Viability

Sources and prevention of graft infection during long term ex situ liver perfusion

2021 ◽  
Author(s):  
Dilmurodjon Eshmuminov ◽  
Matteo Mueller ◽  
Silvio D. Brugger ◽  
Lucia Bautista Borrego ◽  
Dustin Becker ◽  
...  
Keyword(s):  
Liver Perfusion ◽  
Graft Infection ◽  
Ex Situ

“Synthesis of coagulation factors during long‐term ex situ liver perfusion”

2021 ◽  
Author(s):  
Dilmurodjon Eshmuminov ◽  
Max Hefti ◽  
Matteo Mueller ◽  
Martin J. Schuler ◽  
Lucia Bautista Borrego ◽  
...  
Keyword(s):  
Liver Perfusion ◽  
Coagulation Factors ◽  
Ex Situ

scholarly journals Th1/Th2cytokines and ICAM–1 levels post-liver transplant do not predict early rejection

2000 ◽  
Vol 9 (1) ◽  
pp. 35-38 ◽  
Author(s):  
E. Granot ◽  
A. Tarcsafalvi ◽  
S. Emre ◽  
P. Sheiner ◽  
S. Guy ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Transplant ◽  
Immunosuppressive Therapy ◽  
Allograft Rejection ◽  
Liver Perfusion ◽  
Percentage Increase ◽  
Plasma Samples ◽  
Liver Allograft ◽  
Predominant Factor ◽  
Ifn Γ

Th1derived cytokines IFN-γ and IL–2, Th2cytokine IL–4, and ICAM–1 have been implicated in liver allograft rejection. In order to determine whether monitoring of cytokine profiles during the first days post-liver transplant can predict early rejection we measured IFN-gg, IL–2, sIL–2 receptor, IL–4 and ICAM–1 in 22 patients, in plasma samples obtained within 4h after liver perfusion (baseline) and between postoperative days (POD) 3–6. ICAM–1 and sIL–2R levels at POD 3–6 were significantly higher than at baseline but did not differ in presence or absence of rejection. Mean percentage increase of ICAM–1 levels was significantly lower in patients with Muromonab-C3Orthoclone OKT3(J.C. Health Care) (OKT3) whereas percentage increase of sIL–2R levels was higher in OKT3-treated patients. IFN-γ levels at POD 3–6 increased from baseline while IL–4 levels were unchanged. Levels of IFN-γ, IL–4 and their ratios did not correlate with rejection or immunosuppressive therapy. Thus, Th1/Th2cytokine monitoring during the first week post-transplant does not predict early rejection and immunosuppressive therapy is the predominant factor affecting ICAM and sIL–2R levels after liver transplantation.

scholarly journals Ex Situ Dual Hypothermic Oxygenated Machine Perfusion for Human Split Liver Transplantation

2021 ◽  
Vol 7 (3) ◽  
pp. e666
Author(s):  
Adam M. Thorne ◽  
Veerle Lantinga ◽  
Silke Bodewes ◽  
Ruben H. J. de Kleine ◽  
Maarten W. Nijkamp ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Ex Situ ◽  
Machine Perfusion ◽  
Split Liver Transplantation ◽  
Split Liver

Successful ex vivo liver perfusion system for hepatic failure pending liver regeneration or liver transplantation

2001 ◽  
Vol 33 (1-2) ◽  
pp. 1962-1964 ◽  
Author(s):  
G.M Abouna ◽  
P Ganguly ◽  
S Jabur ◽  
W Tweed ◽  
H Hamdy ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Regeneration ◽  
Hepatic Failure ◽  
Ex Vivo ◽  
Liver Perfusion ◽  
Perfusion System

Recent advances in liver transplantation

2021 ◽  
pp. flgastro-2020-101425
Author(s):  
N Thomas Burke ◽  
James B Maurice ◽  
David Nasralla ◽  
Jonathan Potts ◽  
Rachel Westbrook
Keyword(s):  
Liver Transplantation ◽  
Survival Rates ◽  
Machine Perfusion ◽  
Allocation System ◽  
Life Saving ◽  
Opt Out ◽  
Normothermic Machine Perfusion ◽  
Marginal Grafts ◽  
Legislative Changes ◽  
The Uk

Liver transplant is a life-saving treatment with 1-year and 5-year survival rates of 90% and 70%, respectively. However, organ demand continues to exceed supply, such that many patients will die waiting for an available organ. This article reviews for the general gastroenterologist the latest developments in the field to reduce waiting list mortality and maximise utilisation of available organs. The main areas covered include legislative changes in organ donation and the new ‘opt-out’ systems being rolled out in the UK, normothermic machine perfusion to optimise marginal grafts, a new national allocation system to maximise benefit from each organ and developments in patient ‘prehabilitation’ before listing. Current areas of research interest, such as immunosuppression withdrawal, are also summarised.

Safe use of Liver Grafts from Syphilis-Positive Donors in Liver Transplantation and Review of the Literature

2020 ◽  
Author(s):  
Xin Duan ◽  
Liting Yan ◽  
Chao Qian ◽  
Wei Zhang ◽  
Yan Shen ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Propensity Score ◽  
Liver Function ◽  
Hospital Stay ◽  
Organ Transplantation ◽  
Case Reports ◽  
Benzathine Penicillin ◽  
Review Of The Literature ◽  
Function Recovery ◽  
Marginal Grafts

Abstract Background: The growing disparity between organ availability and the number of candidates for organ transplantation has urged the use of marginal grafts including grafts from syphilis-positive donors. However, few knowledges could be acknowledged about this due to the rare data from case reports. Therefor we evaluate our data and summarize our experience of the management of liver grafts from syphilis-positive donors.Methods: From January 2015 to December 2019, 22 adult patients received liver transplantation from syphilis-positive donors while 873 patients got liver transplantation from syphilis-negative donors at our center. Given the imbalance in several baseline variables, propensity score matching was used. The outcomes were compared including complications, hospital stay, recovery of liver function and survival of the two groups and the management of the recipients was reviewed.Results: There were no differences in complications and hospital stay of the recipients after transplantation. And it showed similar trends in the liver function recovery. Patient and graft survivals were comparable to that of syphilis-negative grafts. And benzathine penicillin is effective to protect the recipients from syphilis.Conclusions: The use of liver grafts from syphilis-positive donors does not to increase the morbidity and mortality of the recipients. Also, the prophylactic theory of benzathine penicillin is helpful.

Hypothermic Oxygenated Liver Perfusion (HOPE) Prevents Tumor Recurrence in Liver Transplantation From Donation After Circulatory Death

2020 ◽  
Vol 272 (5) ◽  
pp. 759-765
Author(s):  
Matteo Mueller ◽  
Marit Kalisvaart ◽  
Joanne O‘Rourke ◽  
Shishir Shetty ◽  
Alessandro Parente ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Tumor Recurrence ◽  
Liver Perfusion ◽  
Donation After Circulatory Death ◽  
Circulatory Death

scholarly journals Normothermic Ex-vivo Liver Perfusion and the Clinical Implications for Liver Transplantation

2018 ◽  
Vol 6 (3) ◽  
pp. 1-7 ◽  
Author(s):  
Clifford Akateh ◽  
Eliza W. Beal ◽  
Bryan A. Whitson ◽  
Sylvester M. Black
Keyword(s):  
Liver Transplantation ◽  
Ex Vivo ◽  
Liver Perfusion ◽  
Clinical Implications

Determination of Minimal Hemoglobin Level Necessary for Normothermic Porcine Ex Situ Liver Perfusion

2018 ◽  
Vol 102 (8) ◽  
pp. 1284-1292 ◽  
Author(s):  
Mariusz Bral ◽  
Boris Gala-Lopez ◽  
Aducio Thiesen ◽  
Sanaz Hatami ◽  
David L. Bigam ◽  
...  
Keyword(s):  
Liver Perfusion ◽  
Hemoglobin Level ◽  
Ex Situ
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