scholarly journals IL‐2 therapy preferentially expands adoptively transferred donor‐specific Tregs improving skin allograft survival

2019 ◽  
Author(s):  
Kulachelvy Ratnasothy ◽  
Jacintha Jacob ◽  
Sim Tung ◽  
Dominic Boardman ◽  
Robert Ian Lechler ◽  
...  
Keyword(s):  
Allograft Survival ◽  
Skin Allograft

scholarly journals CHBP induces stronger immunosuppressive CD127+ M-MDSC via erythropoietin receptor

2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Jiawei Li ◽  
Guowei Tu ◽  
Weitao Zhang ◽  
Yi Zhang ◽  
Xuepeng Zhang ◽  
...  
Keyword(s):  
Suppressor Cells ◽  
Strong Relationship ◽  
Protein Translation ◽  
Erythropoietin Receptor ◽  
Innate Immune ◽  
Myeloid Derived Suppressor Cells ◽  
Allograft Survival ◽  
Skin Allograft ◽  
Myeloid Progenitor ◽  
Regulatory Cytokine

AbstractErythropoietin (EPO) is not only an erythropoiesis hormone but also an immune-regulatory cytokine. The receptors of EPO (EPOR)2 and tissue-protective receptor (TPR), mediate EPO’s immune regulation. Our group firstly reported a non-erythropoietic peptide derivant of EPO, cyclic helix B peptide (CHBP), which could inhibit macrophages inflammation and dendritic cells (DCs) maturation. As a kind of innate immune regulatory cell, myeloid-derived suppressor cells (MDSCs) share a common myeloid progenitor with macrophages and DCs. In this study, we investigated the effects on MDSCs differentiation and immunosuppressive function via CHBP induction. CHBP promoted MDSCs differentiate toward M-MDSCs with enhanced immunosuppressive capability. Infusion of CHBP-induced M-MDSCs significantly prolonged murine skin allograft survival compared to its counterpart without CHBP stimulation. In addition, we found CHBP increased the proportion of CD11b+Ly6G−Ly6Chigh CD127+ M-MDSCs, which exerted a stronger immunosuppressive function compared to CD11b+Ly6G−Ly6Chigh CD127− M-MDSCs. In CHBP induced M-MDSCs, we found that EPOR downstream signal proteins Jak2 and STAT3 were upregulated, which had a strong relationship with MDSC function. In addition, CHBP upregulated GATA-binding protein 3 (GATA-3) protein translation level, which was an upstream signal of CD127 and regulator of STAT3. These effects of CHBP could be reversed if Epor was deficient. Our novel findings identified a new subset of M-MDSCs with better immunosuppressive capability, which was induced by the EPOR-mediated Jak2/GATA3/STAT3 pathway. These results are beneficial for CHBP clinical translation and MDSC cell therapy in the future.

Long-Term Tolerance and Skin Allograft Survival in CD200tg Mice After Autologous Marrow Transplantation

2014 ◽  
Vol 98 (12) ◽  
pp. 1271-1278 ◽  
Author(s):  
Reginald Gorczynski ◽  
Zhiqi Chen ◽  
Ismat Khatri ◽  
Kai Yu
Keyword(s):  
Marrow Transplantation ◽  
Allograft Survival ◽  
Skin Allograft

scholarly journals Changes in lymphocyte phenotype and increased skin allograft survival after FTY720+FK506 therapy

2008 ◽  
Vol 30 (3) ◽  
Author(s):  
Camila T. Lopes ◽  
Léa B. L. Silva ◽  
Patricia M. Cury ◽  
Emmanuel A. Burdmann ◽  
Valquiria Bueno
Keyword(s):  
Allograft Survival ◽  
Skin Allograft ◽  
Lymphocyte Phenotype

Potent Skin Allograft Survival Prolongation Using a Committed Progenitor Fraction of Bone Marrow in Mice

2004 ◽  
Vol 78 (3) ◽  
pp. 383-391 ◽  
Author(s):  
Edip Akpinar ◽  
Nancy Craighead ◽  
Douglas Smoot ◽  
Douglas A. Hale
Keyword(s):  
Bone Marrow ◽  
Allograft Survival ◽  
Skin Allograft ◽  
Survival Prolongation

Can Bi-Directional Regulation Play a Beneficial Role in Skin Allograft Survival?

2014 ◽  
Vol 98 ◽  
pp. 660
Author(s):  
M. Satomi ◽  
W. Bracamonte-Baran ◽  
E. Jankowska-Gan ◽  
S. Shea ◽  
G. Benichou ◽  
...  
Keyword(s):  
Allograft Survival ◽  
Skin Allograft ◽  
Beneficial Role

Effect of Route of Administration of Antilymphocytic Globulin on Skin Allograft Survival in Rats

Nature ◽  
1970 ◽  
Vol 225 (5238) ◽  
pp. 1140-1141 ◽  
Author(s):  
R. G. DALTON ◽  
J. L. TOURAINE ◽  
N. F. ANDERSON ◽  
M. F. A. WOODRUFF
Keyword(s):  
Route Of Administration ◽  
Allograft Survival ◽  
Skin Allograft
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