scholarly journals R707, a fully human antibody directed against CC-chemokine receptor 7, attenuates xenogeneic acute graft-versus-host disease

2019 ◽  
Vol 19 (7) ◽  
pp. 1941-1954 ◽  
Author(s):  
Kenneth A. Fowler ◽  
Viktoria Vasilieva ◽  
Ekaterina Ivanova ◽  
Olga Rimkevich ◽  
Andrey Sokolov ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Chemokine Receptor ◽  
Human Antibody ◽  
Host Disease ◽  
Graft Versus Host ◽  
Cc Chemokine ◽  
Cc Chemokine Receptor 7 ◽  
Acute Graft

scholarly journals Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells

Blood ◽  
2010 ◽  
Vol 115 (23) ◽  
pp. 4914-4922 ◽  
Author(s):  
James M. Coghill ◽  
Michael J. Carlson ◽  
Angela Panoskaltsis-Mortari ◽  
Michelle L. West ◽  
Joseph E. Burgents ◽  
...  
Keyword(s):  
T Cells ◽  
Graft Versus Host Disease ◽  
Chemokine Receptor ◽  
Critical Role ◽  
Host Disease ◽  
Graft Versus Host ◽  
Cc Chemokine ◽  
Graft Versus Leukemia ◽  
Cc Chemokine Receptor 7

Abstract CC-chemokine receptor 7 (CCR7) is expressed on the surface of naive T cells, and plays a critical role in their movement into secondary lymphoid tissue. Here, we show that murine T cells lacking CCR7 (CCR7−/−) generate attenuated graft-versus-host disease (GVHD) responses compared with wild-type (WT) cells, with the difference varying inversely with the degree of major histocompatibility complex (MHC) disparity between the donor and recipient. CCR7−/− T cells exhibited an impaired ability to traffic to recipient lymph nodes, with an increased capacity to home to the spleen. CCR7−/− T cells, however, demonstrated a reduced ability to undergo in vivo expansion in the spleen due to impaired interactions with splenic antigen-presenting cells. On a cellular level, CCR7−/− T cells were functionally competent, demonstrating a normal in vitro proliferative capacity and a preserved ability to produce inflammatory cytokines. Importantly, CCR7−/− T cells were capable of generating robust graft-versus-leukemia (GVL) responses in vivo, as well as complete donor T-cell reconstitution. CCR7−/− regulatory T cells were able to protect against lethal GVHD when administered before WT conventional T cells. Our data suggest that CCR7 inhibition in the early posttransplantation period may represent a feasible new therapeutic approach for acute GVHD attenuation without compromising GVL responses.

scholarly journals Differential Effects of Gut-Homing Molecules CC Chemokine Receptor 9 and Integrin-β7 during Acute Graft-versus-Host Disease of the Liver

2015 ◽  
Vol 21 (12) ◽  
pp. 2069-2078 ◽  
Author(s):  
Alina Schreder ◽  
Georgios Leandros Moschovakis ◽  
Stephan Halle ◽  
Jerome Schlue ◽  
Chun-Wei Lee ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Chemokine Receptor ◽  
Host Disease ◽  
Differential Effects ◽  
Graft Versus Host ◽  
Cc Chemokine ◽  
Acute Graft

scholarly journals CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease

Blood ◽  
2013 ◽  
Vol 122 (5) ◽  
pp. 825-836 ◽  
Author(s):  
James M. Coghill ◽  
Kenneth A. Fowler ◽  
Michelle L. West ◽  
LeShara M. Fulton ◽  
Hendrik van Deventer ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Chemokine Receptor ◽  
Host Disease ◽  
Graft Versus Host ◽  
Cc Chemokine ◽  
Key Points

Key Points Extended donor Treg survival is required for protection from GVHD; donor Treg longevity depends on Treg CCR8 expression. Donor CD11c+ APCs promote Treg longevity in vivo; host CD11c+ APCs do not appear to contribute to donor Treg reconstitution.

scholarly journals CC Chemokine Receptor 2 Expression in Donor Cells Serves an Essential Role in Graft-versus-Host-Disease

2003 ◽  
Vol 171 (9) ◽  
pp. 4875-4885 ◽  
Author(s):  
Arun R. Rao ◽  
Marlon P. Quinones ◽  
Edgar Garavito ◽  
Yogeshwar Kalkonde ◽  
Fabio Jimenez ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Chemokine Receptor ◽  
Essential Role ◽  
Host Disease ◽  
Graft Versus Host ◽  
Cc Chemokine ◽  
Donor Cells ◽  
Cc Chemokine Receptor 2
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