scholarly journals Steroid pretreatment of organ donors does not impact on early rejection and long‐term kidney allograft survival: Results from a multicenter randomized, controlled trial

2019 ◽  
Vol 19 (6) ◽  
pp. 1770-1776 ◽  
Author(s):  
Roman Reindl‐Schwaighofer ◽  
Alexander Kainz ◽  
Kira Jelencsics ◽  
Andreas Heinzel ◽  
Gabriela Berlakovich ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Organ Donors ◽  
Allograft Survival ◽  
Kidney Allograft ◽  
Randomized Controlled ◽  
Multicenter Randomized Controlled Trial

Sustainable effect of skin stretching for burn scar excision: Long-term results of a multicenter randomized controlled trial

Burns ◽  
2011 ◽  
Vol 37 (7) ◽  
pp. 1222-1228 ◽  
Author(s):  
Pauline D.H.M. Verhaegen ◽  
Martijn B.A. van der Wal ◽  
Monica C.T. Bloemen ◽  
Jan Dokter ◽  
Paris Melis ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Long Term Results ◽  
Burn Scar ◽  
Randomized Controlled ◽  
Skin Stretching ◽  
Multicenter Randomized Controlled Trial

scholarly journals NeuroExercise: The Effect of a 12-Month Exercise Intervention on Cognition in Mild Cognitive Impairment—A Multicenter Randomized Controlled Trial

2021 ◽  
Vol 12 ◽  
Author(s):  
Tim Stuckenschneider ◽  
Marit L. Sanders ◽  
Kate E. Devenney ◽  
Justine A. Aaronson ◽  
Vera Abeln ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Exercise Intervention ◽  
Controlled Trial ◽  
Group Differences ◽  
Randomized Controlled ◽  
Amnestic Mci ◽  
Multicenter Randomized Controlled Trial

Exercise intervention studies in mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD), have demonstrated inconsistent yet promising results. Addressing the limitations of previous studies, this trial investigated the effects of a 12-month structured exercise program on the progression of MCI. The NeuroExercise study is a multicenter randomized controlled trial across three European countries (Ireland, Netherlands, Germany). Hundred and eighty-three individuals with amnestic MCI were included and were randomized to a 12-month exercise intervention (3 units of 45 min) of either aerobic exercise (AE; n = 60), stretching and toning exercise (ST; n = 65) or to a non-exercise control group (CG; n = 58). The primary outcome, cognitive performance, was determined by an extensive neuropsychological test battery. For the primary complete case (CC) analyses, between-group differences were analyzed with analysis of covariance under two conditions: (1) the exercise group (EG = combined AE and ST groups) compared to the CG and (2) AE compared to ST. Primary analysis of the full cohort (n = 166, 71.5 years; 51.8% females) revealed no between-group differences in composite cognitive score [mean difference (95% CI)], 0.12 [(−0.03, 0.27), p = 0.13] or in any cognitive domain or quality of life. VO2 peak was significantly higher in the EG compared to the CG after 12 months [−1.76 (−3.39, −0.10), p = 0.04]. Comparing the two intervention groups revealed a higher VO2peak level in the aerobic exercise compared to the stretching and toning group, but no differences for the other outcomes. A 12-month exercise intervention did not change cognitive performance in individuals with amnestic MCI in comparison to a non-exercise CG. An intervention effect on physical fitness was found, which may be an important moderator for long term disease progression and warrants long-term follow-up investigations.Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/NCT02913053, identifier: NCT02913053.

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