scholarly journals Stem Cell-Derived Pancreatic Progenitor Cells Have Now Been Transplanted into Patients: Report from IPITA 2018

2018 ◽  
Vol 18 (7) ◽  
pp. 1581-1582 ◽  
Author(s):  
Lara C. Pullen
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells

scholarly journals Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice

2015 ◽  
Vol 5 (6) ◽  
pp. 1081-1096 ◽  
Author(s):  
Jennifer E. Bruin ◽  
Ali Asadi ◽  
Jessica K. Fox ◽  
Suheda Erener ◽  
Alireza Rezania ◽  
...  
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Human Stem Cell ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells ◽  
Insulin Secreting Cells

scholarly journals Forkhead Protein FoxO1 Acts as a Repressor to Inhibit Cell Differentiation in Human Fetal Pancreatic Progenitor Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Zongzhe Jiang ◽  
Jingjing Tian ◽  
Wenjian Zhang ◽  
Hao Yan ◽  
Liping Liu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Progenitor Cells ◽  
Nude Mice ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells ◽  
In Vitro Induction

Our colleagues have reported previously that human pancreatic progenitor cells can readily differentiate into insulin-containing cells. Particularly, transplantation of these cell clusters upon in vitro induction for 3-4 w partially restores hyperglycemia in diabetic nude mice. In this study, we used human fetal pancreatic progenitor cells to identify the forkhead protein FoxO1 as the key regulator for cell differentiation. Thus, induction of human fetal pancreatic progenitor cells for 1 week led to increase of the pancreatic β cell markers such as Ngn3, but decrease of stem cell markers including Oct4, Nanog, and CK19. Of note, FoxO1 knockdown or FoxO1 inhibitor significantly upregulated Ngn3 and insulin as well as the markers such as Glut2, Kir6.2, SUR1, and VDCC, which are designated for mature β cells. On the contrary, overexpression of FoxO1 suppressed the induction and reduced expression of these β cell markers. Taken together, these results suggest that FoxO1 may act as a repressor to inhibit cell differentiation in human fetal pancreatic progenitor cells.

Oncogene-mediated mouse pancreatic progenitor cells show cancer stem cell phenotype

Pancreatology ◽  
2016 ◽  
Vol 16 (4) ◽  
pp. S143
Author(s):  
Yuuki Ise ◽  
Kazuya Shimizu ◽  
Kyohei Uenoyama ◽  
Satoshi Nishiyama ◽  
Yuka Tsuchida ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Progenitor Cells ◽  
Cell Phenotype ◽  
Pancreatic Progenitor ◽  
Cancer Stem Cell Phenotype ◽  
Pancreatic Progenitor Cells ◽  
Stem Cell Phenotype
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