scholarly journals Heme oxygenase-1 regulates sirtuin-1-autophagy pathway in liver transplantation: From mouse to human

2017 ◽  
Vol 18 (5) ◽  
pp. 1110-1121 ◽  
Author(s):  
Kojiro Nakamura ◽  
Shoichi Kageyama ◽  
Shi Yue ◽  
Jing Huang ◽  
Takehiro Fujii ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Heme Oxygenase ◽  
Sirtuin 1 ◽  
Heme Oxygenase 1 ◽  
Autophagy Pathway

scholarly journals Combination of Early Allograft Dysfunction and Protein Expression Patterns Predicts Outcome of Liver Transplantation From Donation After Cardiac Death

2021 ◽  
Vol 8 ◽  
Author(s):  
Qiang Wei ◽  
Junbin Zhou ◽  
Kun Wang ◽  
Xuanyu Zhang ◽  
Junli Chen ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Expression Patterns ◽  
Sirtuin 1 ◽  
Donation After Cardiac Death ◽  
Heme Oxygenase 1 ◽  
Survival Prognosis ◽  
Allograft Dysfunction ◽  
Tnf Α ◽  
Factor Α ◽  
Early Allograft Dysfunction

Early allograft dysfunction (EAD) after liver transplantation (LT) accompanies poor prognosis. This study aims to explore the relationship between pretransplant intrahepatic proteins and the incidence of EAD, and the value of combined EAD and protein profiles for predicting recipient and graft survival prognosis. Liver biopsy specimens of 105 pretransplant grafts used for LT were collected and used for immunohistochemistry analysis of 5 proteins. And matched clinical data of donor, recipient, transplantation, and prognosis were analyzed. The incidence of EAD was 41.9% (44/105) in this cohort. Macrovesicular steatosis (P = 0.016), donor body mass index (P = 0.013), recipients' pretransplant serum creatinine (P = 0.036), and intrahepatic expression of heme oxygenase 1 (HO1) (P = 0.015) and tumor necrosis factor α (TNF-α) (P = 0.039) were independent predictors of EAD. Inferior graft and recipient prognosis were observed in patients who experienced EAD (P = 0.028 and 0.031) or received grafts with higher expression of sirtuin 1 (P = 0.005 and 0.013). The graft and recipient survival were worst in patients with both EAD and high expression of sirtuin 1 (P = 0.001 and 0.004). In conclusion, pretransplant intrahepatic expression of HO1 and TNF-α are associated with the incidence of EAD. The combination of EAD and EAD-unrelated proteins showed superiority in distinguishing recipients with worse prognosis.

Induction of heme oxygenase 1 in rats improves survival after liver transplantation by inhibiting apoptosis

2001 ◽  
Vol 34 ◽  
pp. 41
Author(s):  
C.A. Redaelli ◽  
Y.H. Tian ◽  
M.K. Schilling ◽  
J.-F. Dufour
Keyword(s):  
Liver Transplantation ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1

scholarly journals Improvement of Liver Transplantation Outcome by Heme Oxygenase-1-Transduced Bone Marrow Mesenchymal Stem Cells in Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Bin Wu ◽  
Hong-Li Song ◽  
Yang Yang ◽  
Ming-Li Yin ◽  
Bo-Ya Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Liver Transplantation ◽  
Mesenchymal Stem Cells ◽  
Heme Oxygenase ◽  
Transforming Growth Factor ◽  
The Other ◽  
Heme Oxygenase 1 ◽  
Immunomodulatory Effects ◽  
Marrow Mesenchymal Stem Cells

Bone marrow mesenchymal stem cells (BMMSCs) exert immunosuppressive activity in transplantation, and heme oxygenase-1 (HO-1) enhances their immunomodulatory effects. The aim of this study was to determine whether HO-1-transduced BMMSCs (HO-1/MSCs) improve rat liver transplantation (LTx) outcomes. Orthotopic LTx rejection models were treated with HO-1/MSCs, BMMSCs, HO-1, or normal saline, respectively. Our results showed a significant improvement in survival rates in the HO-1/BMMSCs group compared to the control groups. At all time points, liver function marker levels in the HO-1/MSCs group were significantly lower than in the other three groups; on POD 1, 7, and 14, the degree of rejection and apoptotic cells was significantly less in the HO-1/MSCs group than in the other three groups. Interleukin- (IL-) 10 and transforming growth factor-βlevels were significantly increased, while IL-2, IL-6, IL-17, IL-23, tumor necrosis factor-α, and interferon-γlevels were significantly decreased in the HO-1/MSCs group when compared to the other groups. Splenocyte Tregs were significantly increased by HO-1/MSCs compared with controls on POD 3, 5, 7, 10, 14, and 28. Summarily, we provide evidence that HO-1/MSCs improved allogeneic LTx outcomes by attenuating inflammatory responses and acute cellular rejection, as well as enhanced immunomodulatory effects compared with BMMSCs.

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