scholarly journals Passenger Leukocytes Revisited: One Passenger That Refuses to Leave the Airspace

2016 ◽  
Vol 16 (8) ◽  
pp. 2247-2249
Author(s):  
W. J. Burlingham ◽  
R. K. Braun ◽  
K. C. Meyer
Keyword(s):  
Passenger Leukocytes

Restoration of tolerance to rat hepatic allografts by spleen-derived passenger leukocytes

1996 ◽  
Vol 9 (6) ◽  
pp. 593-595 ◽  
Author(s):  
Yoshinori Shimizu ◽  
Shigeru Goto ◽  
Roger Lord ◽  
Frank Vari ◽  
Catherine Edwards-Smith ◽  
...  
Keyword(s):  
Passenger Leukocytes

Third-party passenger leukocytes prolong liver allograft survival

2001 ◽  
Vol 33 (1-2) ◽  
pp. 171-172
Author(s):  
D Kreisel ◽  
H Petrowsky ◽  
A.M Krasinskas ◽  
W.Y Szeto ◽  
A.S Krupnick ◽  
...  
Keyword(s):  
Third Party ◽  
Allograft Survival ◽  
Liver Allograft ◽  
Passenger Leukocytes

scholarly journals Recipient-matching of Passenger Leukocytes Prolongs Survival of Donor Lung Allografts in Miniature Swine

2015 ◽  
Vol 99 (7) ◽  
pp. 1372-1378 ◽  
Author(s):  
Maria Lucia L. Madariaga ◽  
Sebastian G. Michel ◽  
Glenn M. La Muraglia ◽  
Smita Sihag ◽  
David A. Leonard ◽  
...  
Keyword(s):  
Miniature Swine ◽  
Donor Lung ◽  
Passenger Leukocytes

Role of donor passenger leukocytes on the induction of tolerance in rat liver transplantation

1998 ◽  
Vol 30 (7) ◽  
pp. 3852-3853 ◽  
Author(s):  
S Chiba ◽  
S Goto ◽  
R Lord ◽  
Y Shimizu ◽  
S Kobayashi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Rat Liver ◽  
Rat Liver Transplantation ◽  
Passenger Leukocytes ◽  
Induction Of Tolerance

scholarly journals Suppression of liver transplant rejection by anti-donor MHC antibodies via□ depletion of donor immunogenic dendritic cells

2020 ◽  
Author(s):  
Hisashi Ueta ◽  
Xue-Dong Xu ◽  
Bin Yu ◽  
Yusuke Kitazawa ◽  
Enqiao Yu ◽  
...  
Keyword(s):  
T Cell ◽  
Liver Transplant ◽  
Transplant Rejection ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Cellular Damage ◽  
Class I Mhc ◽  
Class Ii Mhc ◽  
Passenger Leukocytes ◽  
Liver Transplant Rejection

Abstract Background We previously found two distinct passenger dendritic cell (DC) subsets in the rat liver that played a central role in the liver transplant rejection. In addition, tolerance-inducing protocol, donor-specific transfusion (DST), triggered systemic polytopical production of depleting alloantibodies to donor class I MHC antigen (DST-antibodies). Methods We examined the role of DST-antibodies in the trafficking of graft DC subsets and the alloresponses in a rat model. We also examined an anti-donor class II MHC (MHCII) antibody that recognizes donor DCs more selectively. Results Preoperative transfer of DST-antibodies and DST pretreatments eliminated all passenger leukocytes, including both DC subsets and depleted the sessile DCs in the graft to ~20% of control. The CD172a +CD11b/c + immunogenic subset was almost abolished. The intrahost direct or semi-direct allorecognition pathway was successfully blocked, leading to a significant suppression of the CD8 + T-cell response in the recipient lymphoid organs and the graft with delayed graft rejection. Anti-donor MHCII antibody had similar effects without temporary graft damage. Although DST pretreatment had a priming effect on the recipient Treg proliferative response, DST-primed sera and the anti-donor MHCII antibody did not. Conclusion DST-antibodies and anti-donor MHCII antibodies could suppress the CD8 + T-cell-mediated liver transplant rejection by depleting donor immunogenic DCs, blocking the direct or semi-direct pathway of allorecognition. Donor MHCII-specific antibodies may be applicable as a selective suppressant of anti-donor immunity for clinical liver transplantation without the cellular damage of donor MHCII – graft cells and recipient cells.

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