scholarly journals Rat Cytomegalovirus Vaccine Prevents Accelerated Chronic Rejection in CMV‐Naïve Recipients of Infected Donor Allograft Hearts

2015 ◽  
Vol 15 (7) ◽  
pp. 1805-1816 ◽  
Author(s):  
D. N. Streblow ◽  
Y. K. Hwee ◽  
C. N. Kreklywich ◽  
T. Andoh ◽  
M. Denton ◽  
...  
Keyword(s):  
Chronic Rejection ◽  
Infected Donor ◽  
Cytomegalovirus Vaccine

Macrophage depletion of CMV latently infected donor hearts ameliorates recipient accelerated chronic rejection

2020 ◽  
Author(s):  
Nicole N. Haese ◽  
Jennifer M. Burg ◽  
Takeshi F. Andoh ◽  
Iris K. A. Jones ◽  
Craig N. Kreklywich ◽  
...  
Keyword(s):  
Chronic Rejection ◽  
Macrophage Depletion ◽  
Infected Donor ◽  
Latently Infected

scholarly journals RhoA- and Actin-Dependent Functions of Macrophages from the Rodent Cardiac Transplantation Model Perspective -Timing Is the Essence

Biology ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 70
Author(s):  
Malgorzata Kloc ◽  
Ahmed Uosef ◽  
Martha Villagran ◽  
Robert Zdanowski ◽  
Jacek Z. Kubiak ◽  
...  
Keyword(s):  
Immune Response ◽  
Circadian Rhythm ◽  
Immune Cells ◽  
Chronic Rejection ◽  
Cardiac Transplantation ◽  
Small Gtpase ◽  
Eukaryotic Cells ◽  
Transplantation Model

The small GTPase RhoA, and its down-stream effector ROCK kinase, and the interacting Rac1 and mTORC2 pathways, are the principal regulators of the actin cytoskeleton and actin-related functions in all eukaryotic cells, including the immune cells. As such, they also regulate the phenotypes and functions of macrophages in the immune response and beyond. Here, we review the results of our and other’s studies on the role of the actin and RhoA pathway in shaping the macrophage functions in general and macrophage immune response during the development of chronic (long term) rejection of allografts in the rodent cardiac transplantation model. We focus on the importance of timing of the macrophage functions in chronic rejection and how the circadian rhythm may affect the anti-chronic rejection therapies.

scholarly journals Antibodies to MHC Class I Induce Autoimmunity: Role in the Pathogenesis of Chronic Rejection

2008 ◽  
Vol 182 (1) ◽  
pp. 309-318 ◽  
Author(s):  
Naohiko Fukami ◽  
Sabarinathan Ramachandran ◽  
Deepti Saini ◽  
Michael Walter ◽  
William Chapman ◽  
...  
Keyword(s):  
Mhc Class I ◽  
Chronic Rejection ◽  
Class I

CHRONIC REJECTION OF THE LIVER ALLOGRAFT

1993 ◽  
Vol 22 (2) ◽  
pp. 401-420
Author(s):  
John R. Lowes ◽  
Stefan G. Hubscher ◽  
James M. Neuberger
Keyword(s):  
Chronic Rejection ◽  
Liver Allograft

Clinical Impacts and Outcomes With Possible Donor-Derived Infection in Infected Donor Liver Transplantation: A Single-Center Retrospective Study in China

2020 ◽  
Vol 221 (Supplement_2) ◽  
pp. S164-S173
Author(s):  
Li Tong ◽  
Xiao-Guang Hu ◽  
Fa Huang ◽  
Shun-Wei Huang ◽  
Li-Fen Li ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Antibiotic Sensitivity ◽  
Resistant Bacteria ◽  
Single Center ◽  
Sensitivity Testing ◽  
Donor Liver Transplantation ◽  
Infected Donor ◽  
Recipient Group ◽  
Deceased Donors ◽  
Liver Recipient

Abstract Background Information on possible donor-derived transmission events in China is limited. We evaluated the impacts of liver transplantation from infected deceased-donors, analyzed possible donor-derived bacterial or fungal infection events in recipients, and evaluated the etiologic agents’ characteristics and cases outcomes. Methods A single-center observational study was performed from January 2015 to March 2017 to retrospectively collect data from deceased-donors diagnosed with infection. Clinical data were recorded for each culture-positive donor and the matched liver recipient. The microorganisms were isolated and identified, and antibiotic sensitivity testing was performed. The pathogens distribution and incidence of possible donor-derived infection (P-DDI) events were analyzed and evaluated. Results Information from 211 donors was collected. Of these, 82 donors were infected and classified as the donation after brain death category. Overall, 149 and 138 pathogens were isolated from 82 infected donors and 82 matched liver recipients, respectively. Gram-positive bacteria, Gram-negative bacteria, and fungi accounted for 42.3% (63 of 149), 46.3% (69 of 149), and 11.4% (17 of 149) of pathogens in infected donors. The incidence of multidrug-resistant bacteria was high and Acinetobacter baumannii was the most concerning species. Infections occurred within the first 2 weeks after liver transplantation with an organ from an infected donor. Compared with the noninfection recipient group, the infection recipient group experienced a longer mechanical ventilation time (P = .004) and intensive care unit stay (P = .003), a higher incidence of renal dysfunction (P = .026) and renal replacement therapy (P = .001), and higher hospital mortality (P = .015). Possible donor-derived infection was observed in 14.6% of cases. Recipients with acute-on-chronic liver failure were more prone to have P-DDI than recipients with other diseases (P = .007; odds ratio = 0.114; 95% confidence interval, .025–.529). Conclusions When a liver recipient receives a graft from an infected deceased-donor, the postoperative incidence of infection is high and the infection interval is short. In addition, when a possible donor-derived, drug-resistant bacterial infection occurs, recipients may have serious complications and poor outcomes.

scholarly journals Dissecting Serial Immune Response Stages of Chronic Rejection after Murine Orthotopic Lung Transplantation

2021 ◽  
Vol 40 (4) ◽  
pp. S305-S306
Author(s):  
T. Heigl ◽  
J. Kaes ◽  
C. Aelbrecht ◽  
G. Vande Velde ◽  
A. Vanstapel ◽  
...  
Keyword(s):  
Immune Response ◽  
Lung Transplantation ◽  
Chronic Rejection
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