scholarly journals Genetic Variation in Immunoglobulin G Receptor Affects Survival After Lung Transplantation

2014 ◽  
Vol 14 (7) ◽  
pp. 1672-1677 ◽  
Author(s):  
D. Ruttens ◽  
S. E. Verleden ◽  
P. C. Goeminne ◽  
E. Vandermeulen ◽  
E. Wauters ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Lung Transplantation ◽  
Immunoglobulin G ◽  
Immunoglobulin G Receptor

scholarly journals Genetic Variation in Immunoglobulin G Receptor Affects Survival After Lung Transplantation

2014 ◽  
Vol 33 (4) ◽  
pp. S30
Author(s):  
D. Ruttens ◽  
S.E. Verleden ◽  
P.C. Goeminne ◽  
E. Vandermeulen ◽  
E. Wauters ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Lung Transplantation ◽  
Immunoglobulin G ◽  
Immunoglobulin G Receptor

scholarly journals Detrimental Association of Hypogammaglobulinemia With Chronic Lung Allograft Dysfunction and Death Is Not Mitigated by On-Demand Immunoglobulin G Replacement After Lung Transplantation

2018 ◽  
Vol 29 (1) ◽  
pp. 18-25
Author(s):  
Alicia B. Lichvar ◽  
Christopher R. Ensor ◽  
Adriana Zeevi ◽  
Matthew R. Morrell ◽  
Joseph M. Pilewski ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Immunoglobulin G ◽  
Lung Transplant ◽  
Primary Outcome ◽  
Transplant Recipients ◽  
Chronic Lung Allograft Dysfunction ◽  
On Demand ◽  
Allograft Dysfunction ◽  
Group 2 ◽  
Lung Transplant Recipients

Background: Hypogammaglobulinemia (HGG), immunoglobulin G (IgG) <700 mg/dL, is associated with infections, chronic lung allograft dysfunction, and death following lung transplantation. This study evaluates the use of on-demand intravenous IgG in lung transplant recipients with HGG. Materials and Methods: This single-center retrospective cohort study of adult lung recipients evaluated 3 groups, no, untreated (u), or treated (t) HGG at first IgG administration or a matched time posttransplant. Primary outcome was freedom from allograft dysfunction. Secondary outcomes included development of advanced dysfunction, rejection, infection burden, and mortality. Results: Recipients included 484 (no HGG: 76, uHGG: 192, tHGG: 216). Freedom from chronic allograph dysfunction was highest in the non-HGG group 2 years post-enrollment (no HGG 77.9% vs uHGG 56.4% vs tHGG 52.5%; P = .002). Freedom from advanced dysfunction was significantly different 2 years post-enrollment (no HGG 90.5% vs uHGG 84.7% vs tHGG 75.4%; P = .017). Patients without HGG and those with uHGG had less mortality at 2 years post-enrollment (no HGG 84.2% vs uHGG 81.3% vs tHGG 64.8%; P < .001). Gram-negative pneumonias occurred more often in the tHGG group ( P = .02). Conclusions: Development of chronic lung allograft dysfunction, patient survival, rejection burden, and key infectious outcomes in lung transplant recipients were still problematic in the context of on-demand IgG therapy. Prospective studies are warranted.

Demonstration of immunoglobulin G receptors induced by human cytomegalovirus

1975 ◽  
Vol 2 (4) ◽  
pp. 332-336
Author(s):  
T Furukawa ◽  
E Hornberger ◽  
S Sakuma ◽  
S A Plotkin
Keyword(s):  
Human Cytomegalovirus ◽  
Immunoglobulin G ◽  
Human Fibroblasts ◽  
Antiviral Agents ◽  
Perinuclear Region ◽  
Immunoglobulin G Receptor ◽  
Source Of Error

Human cytomegalovirus induced a new immunoglobulin G receptor in human fibroblasts. The immunoglobulin G receptor was well localized in the perinuclear region at 48 h postinfection, and antiviral agents blocked its synthesis. The immunoglobulin G receptor bound immunoglobulin G of man and several other species. It may be a source of error in the performance of indirect fluorescence tests for human cytomegalovirus antibody.

scholarly journals Genetic variation in interleukin-17 receptor A is functionally associated with chronic rejection after lung transplantation

2013 ◽  
Vol 32 (12) ◽  
pp. 1233-1240 ◽  
Author(s):  
David Ruttens ◽  
Els Wauters ◽  
Michal Kiciński ◽  
Stijn E. Verleden ◽  
Elly Vandermeulen ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Lung Transplantation ◽  
Chronic Rejection ◽  
Interleukin 17

scholarly journals Immunoglobulin G Levels before and after Lung Transplantation

2006 ◽  
Vol 173 (8) ◽  
pp. 917-921 ◽  
Author(s):  
Natalie H. Yip ◽  
David J. Lederer ◽  
Steven M. Kawut ◽  
Jessie S. Wilt ◽  
Frank D'Ovidio ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Immunoglobulin G ◽  
Before And After

The human placental immunoglobulin G receptor and immunoglobulin G transport

1994 ◽  
Vol 171 (1) ◽  
pp. 258-263 ◽  
Author(s):  
Barbro E. Fridén ◽  
Ricardo Makiya ◽  
Berith M. Nilsson ◽  
Stig Holm ◽  
Torgny I. Stigbrand
Keyword(s):  
Immunoglobulin G ◽  
Immunoglobulin G Receptor

Genetic Variation in Caveolin-1 Affects Survival After Lung Transplantation

2014 ◽  
Vol 98 (3) ◽  
pp. 354-359 ◽  
Author(s):  
Elly Vandermeulen ◽  
David Ruttens ◽  
Stijn E. Verleden ◽  
Robin Vos ◽  
Dirk E. Van Raemdonck ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Lung Transplantation ◽  
Caveolin 1
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